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Drug: Tetracycline

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Total 16 results found since Jan 2013.

BST2/Tetherin inhibits hepatitis C virus production in human hepatoma cells.
Abstract Hepatitis C virus (HCV) infection is a common cause of chronic hepatitis and is currently treated with alpha interferon (IFN-α)-based therapies. IFN-induced cell membrane protein BST2 (also known as CD317, HM1.24 or tetherin) has been reported to tether a broad range of lipid-enveloped viruses on cell surfaces. However, whether HCV is sensitive to BST2 remains controversial. Here we established a Huh7.5-BST2-TO cell line, in which BST2 expression is regulated by tetracycline. Our results showed that the effect of BST2 on inhibiting HCV production was dependent on its expression level. Highly expressed BS...
Source: Antiviral Research - February 16, 2013 Category: Virology Authors: Pan XB, Qu XW, Jiang D, Zhao XL, Han JC, Wei L Tags: Antiviral Res Source Type: research