Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin

ConclusionOur work unravels a novel driver of photosensitivity in SLE: overactive Hippo signaling in SLE keratinocytes restricts YAP transcriptional activity, leading to shifts that promote UVB apoptosis.

Source: Arthritis and Rheumatology - April 19, 2023 Category: Rheumatology Authors: Grace A. Hile, Patrick Coit, Bin Xu, Amanda M. Victory, Mehrnaz Gharaee ‐Kermani, Shannon N. Estadt, Mitra P. Maz, Jacob W. S. Martens, Rachael Wasikowski, Craig Dobry, Lam C. Tsoi, Ramiro Iglesias‐Bartolome, Celine C. Berthier, Allison C Tags: Full Length Source Type: research