Filtered By:
Drug: Carisoprodol

This page shows you your search results in order of date.

Order by Relevance | Date

Total 22 results found since Jan 2013.

Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations
Neoplasia. 2022 Nov;33:100837. doi: 10.1016/j.neo.2022.100837. Epub 2022 Sep 24.ABSTRACTKRAS is the most commonly mutated oncogene in human cancers with limited therapeutic options, thus there is a critical need to identify novel targets and inhibiting agents. The 78-kDa glucose-regulated protein GRP78, which is upregulated in KRAS cancers, is an essential chaperone and the master regulator of the unfolded protein response (UPR). Following up on our recent discoveries that GRP78 haploinsufficiency suppresses both KRASG12D-driven pancreatic and lung tumorigenesis, we seek to determine the underlying mechanisms. Here, we rep...
Source: Neoplasia - September 26, 2022 Category: Cancer & Oncology Authors: Dat P Ha Bo Huang Han Wang Daisy Flores Rangel Richard Van Krieken Ze Liu Soma Samanta Nouri Neamati Amy S Lee Source Type: research

Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2 γ-mediated pre-initiation complex
CONCLUSIONS: These findings demonstrated that CySC lineage eIF5, together with eIF1A or eIF2γ, mediates soma-germline communications for the stem cell niche homeostasis in Drosophila testes, providing new insights for the prevention of TGCTs.PMID:35883200 | DOI:10.1186/s13287-022-03025-5
Source: Cell Research - July 26, 2022 Category: Cytology Authors: Zhiran Li Yunhao Wu Yangbo Fu Xia Chen Xi Zhao Xiaolong Wu Yajuan Lu Hui He Cong Shen Bo Zheng Jun Yu Fei Sun Source Type: research

Cancers, Vol. 14, Pages 566: Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts
In conclusion, exosome-capturing Ab-conjugated siRNAs with branched Arg linkers can be effectively delivered into MM cells via uptake of exosomes by parental cells. This technology has the potential to lead to a breakthrough in drug delivery systems for hematologic cancers.
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Emi Soma Asako Yamayoshi Yuki Toda Yuji Mishima Shigekuni Hosogi Eishi Ashihara Tags: Article Source Type: research

A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons RESOURCES
Although mosquitoes are major transmission vectors for pathogenic arboviruses, viral infection has little impact on mosquito health. This immunity is caused in part by mosquito RNA interference (RNAi) pathways that generate antiviral small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). RNAi also maintains genome integrity by potently repressing mosquito transposon activity in the germline and soma. However, viral and transposon small RNA regulatory pathways have not been systematically examined together in mosquitoes. Therefore, we developed an integrated mosquito small RNA genomics (MSRG) resource that anal...
Source: Genome Research - March 1, 2021 Category: Genetics & Stem Cells Authors: Ma, Q., Srivastav, S. P., Gamez, S., Dayama, G., Feitosa-Suntheimer, F., Patterson, E. I., Johnson, R. M., Matson, E. M., Gold, A. S., Brackney, D. E., Connor, J. H., Colpitts, T. M., Hughes, G. L., Rasgon, J. L., Nolan, T., Akbari, O. S., Lau, N. C. Tags: RESOURCES Source Type: research

Cancers, Vol. 13, Pages 82: STAT3 Stabilizes IKK α Protein through Direct Interaction in Transformed and Cancerous Human Breast Epithelial Cells
In this study, we observed overexpression and co-localization of IKKα and STAT3 in human breast cancer tissues as well as in H-Ras transformed human breast epithelial (H-Ras MCF-10A) and breast cancer (MDA-MB-231) cells. By utilizing small interfering RNA (siRNA) technology, we were able to demonstrate that STAT3 up-regulated IKKα, but not IKKβ or IKKγ, in these cells. This was attributable to direct binding to and subsequent stabilization of IKKα protein by blocking the ubiquitin-proteasome system. Notably, we identified the lysine 44 residue of IKK&...
Source: Cancers - December 30, 2020 Category: Cancer & Oncology Authors: Young-Il Hahn Soma Saeidi Su-Jung Kim Se-Young Park Na-Young Song Jie Zheng Do-Hee Kim Han-Byoel Lee Wonshik Han Dong-Young Noh Hye-Kyung Na Young-Joon Surh Tags: Article Source Type: research

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment
This study provides important sex- and tissue-specific expression data of miRNA, piRNA and siRNA as well as mechanistic insights into sex-differences of gene regulation in response to environmental cues.
Source: PLoS Genetics - February 8, 2019 Category: Genetics & Stem Cells Authors: Alexandra Bezler Source Type: research

Molecules, Vol. 22, Pages 969: Docosahexaenoic Acid Induces Expression of Heme Oxygenase-1 and NAD(P)H:quinone Oxidoreductase through Activation of Nrf2 in Human Mammary Epithelial Cells
In conclusion, DHA activates Nrf2, possibly through modification of critical Keap1 cysteine 288 residue and PKCδ-mediated phosphorylation of Nrf2, leading to upregulation of HO-1 and NQO1 expression.
Source: Molecules - June 10, 2017 Category: Chemistry Authors: Hye-Yoon Bang Sin-Aye Park Soma Saeidi Hye-Kyung Na Young-Joon Surh Tags: Article Source Type: research

Inhibition of TrkB limits development of the zebra finch song system.
Abstract Large sexual dimorphisms exist in the zebra finch song system. Masculinization may be mediated by both estradiol and expression of one or more Z-genes (males: ZZ; females: ZW). Roles of the Z-gene tyrosine kinase B (TrkB) in HVC in masculinizing both it and its target the robust nucleus of the arcopallium (RA) were tested using siRNA administration in juvenile males at two ages (post-hatching days 15-17 or 25-27). Birds were euthanized 10 days later. Potential interactions or additive effects with estradiol were evaluated by treating males with the estrogen synthesis inhibitor fadrozole. Females treated w...
Source: Brain Research - April 14, 2016 Category: Neurology Authors: Beach LQ, Tang YP, Kerver H, Wade J Tags: Brain Res Source Type: research

GSE67954 CSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline
Contributors : Anne C Campbell ; Dustin L UpdikeSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansP granules in C. elegans are required for fertility and function to maintain germ cell identity and pluripotency.  Sterility in the absence of P granules is often accompanied by the mis-expression of soma-specific proteins and the initiation of somatic differentiation in germ cells.  To investigate whether this is caused by the accumulation of somatic transcripts, we performed mRNA-seq on dissected germlines with and without P granules.  Strikingly, we found that somatic tran...
Source: GEO: Gene Expression Omnibus - May 20, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Caenorhabditis elegans Source Type: research

The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia
In this study, we hypothesized that peripheral inflammation leads to cytokine and chemokine production and ROS generation within TG and that transient receptor potential melastatin (TRPM2), a well known oxidative sensor, contributes to ROS-induced gene regulation within TG. The masseter injection of complete Freund’s adjuvant (CFA) resulted in a significantly elevated level of ROS within TG of the inflamed side with a concurrent increase in cytokine expression in TG. Treatment of TG cultures with H2O2 significantly up-regulated mRNA and protein levels of cytokine/chemokine such as interleukin 6 (IL-6) and chemokine (C-X-...
Source: Neuroscience - April 20, 2015 Category: Neuroscience Source Type: research