Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2 γ-mediated pre-initiation complex

CONCLUSIONS: These findings demonstrated that CySC lineage eIF5, together with eIF1A or eIF2γ, mediates soma-germline communications for the stem cell niche homeostasis in Drosophila testes, providing new insights for the prevention of TGCTs.PMID:35883200 | DOI:10.1186/s13287-022-03025-5

Source: Cell Research - July 26, 2022 Category: Cytology Authors: Zhiran Li Yunhao Wu Yangbo Fu Xia Chen Xi Zhao Xiaolong Wu Yajuan Lu Hui He Cong Shen Bo Zheng Jun Yu Fei Sun Source Type: research