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Drug: Acetaminophen

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Total 23 results found since Jan 2013.

Acid-degradable cationic poly(ketal amidoamine) for enhanced RNA interference in vitro and in vivo.
Abstract Efficient delivery of small interfering RNA (siRNA) is one of major challenges in the successful applications of siRNA in clinic. In the present study, we report a new acid-degradable poly(ketal amidoamine) (PKAA) as a siRNA carrier, which has high delivery efficiency and low cytotoxicity. PKAA was designed to have acid-cleavable ketal linkages in the backbone of cationic biodegradable poly(amidoamine). PKAA efficiently self-assembled with siRNA to form nanocomplexes with a diameter of 200 nm and slightly positive charges, which are stable under physiological conditions, but rapidly release siRNA at ac...
Source: Biomacromolecules - December 16, 2012 Category: Biochemistry Authors: Lim H, Noh J, Kim Y, Kim H, Kim J, Khang G, Lee D Tags: Biomacromolecules Source Type: research

Blockade of Notch signaling promotes acetaminophen-induced liver injury
This study was designed to investigate the role of Notch signaling in the regulation of innate immune responses in acetaminophen (APAP)-induced liver injury. Using a mouse model of APAP-induced liver injury, wild-type (WT) and toll-like receptor 4 knockout (TLR4 KO) mice were injected intraperitoneally with APAP or PBS. Some animals were injected with γ-secretase inhibitor DAPT or DMSO vehicle. For the in vitro study, bone marrow-derived macrophages (BMMs) were transfected with Notch1 siRNA, TLR4 siRNA, and non-specific (NS) siRNA and stimulated with LPS. Indeed, paracetamol/acetaminophen-induced liver damage was worse af...
Source: Immunologic Research - March 12, 2017 Category: Allergy & Immunology Source Type: research

The Involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.
Abstract Quercetin, one of the most abundant dietary flavonoids, is reported to have protective function against various hepatotoxicants-induced hepatotoxicity. The present study aims to investigate the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidative signaling pathway in the protection of quercetin against hepatotoxicity. Quercetin prevented the cytotoxicity induced by a variety of hepatotoxicants including clivorine (Cliv), acetaminophen (APAP), ethanol, carbon tetrachloride (CCl4), and toosendanin (TSN) in human normal liver L-02 cells. Quercetin induced the nuclear translocatio...
Source: Free Radical Biology and Medicine - April 13, 2015 Category: Biology Authors: Ji LL, Sheng YC, Zheng ZY, Shi L, Wang ZT Tags: Free Radic Biol Med Source Type: research

Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway
Int Immunopharmacol. 2023 Jan;114:109558. doi: 10.1016/j.intimp.2022.109558. Epub 2022 Dec 21.ABSTRACTThe overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator of metabolic function, which can alleviate liver damage by scavenging reactive oxygen species (ROS). Evidence suggests that the NOD-like receptor family pyrin domain-containing 3 (NLRP3) -mediated pyroptosis is involved in the development of NAFLD. Moreover, thioredoxin-interactive protein (TXNIP) activation is a key event linking ROS to NLRP3 infl...
Source: International Immunopharmacology - January 26, 2023 Category: Allergy & Immunology Authors: Xiangfu Jiang Yu Li Dongdong Fu Tingyu You Shuai Wu Jiao Xin Jiagen Wen Yan Huang Chengmu Hu Source Type: research

Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways
Publication date: Available online 24 December 2014 Source:Journal of Pharmacological Sciences Author(s): Musen Lin , Xiaohan Zhai , Guangzhi Wang , Xiaofeng Tian , Dongyan Gao , Lei Shi , Hang Wu , Qing Fan , Jinyong Peng , Kexin Liu , Jihong Yao Acetaminophen (APAP) is used drugs worldwide for treating pain and fever. However, APAP overdose is the principal cause of acute liver failure in Western countries. Salvianolic acid B (SalB), a major water-soluble compound extracted from Radix Salvia miltiorrhiza, has well-known antioxidant and anti-inflammatory actions. We aimed to evaluate the ability of SalB to protect again...
Source: Journal of Pharmacological Sciences - December 25, 2014 Category: Drugs & Pharmacology Source Type: research

Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system.
In conclusion, we demonstrated that CA prevented APAP-induced hepatotoxicity by decreasing Keap1 expression, inhibiting binding of Keap1 to Nrf2, and thus activating Nrf2 and leading to increased expression of antioxidative signals including HO-1 and NQO1. PMID: 26721592 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - December 23, 2015 Category: Biology Authors: Pang C, Zheng Z, Shi L, Sheng Y, Wei H, Wang Z, Ji L Tags: Free Radic Biol Med Source Type: research

Activation of GR but not PXR by Dexamethasone Attenuated Acetaminophen Hepatotoxicities via Fgf21 Induction.
In conclusion, via GR activation, DEX induced Fgf21 expression in mouse liver and human hepatoma cells. PMID: 28088388 [PubMed - as supplied by publisher]
Source: Toxicology - January 10, 2017 Category: Toxicology Authors: Vispute SG, Bu P, Le Y, Cheng X Tags: Toxicology Source Type: research

Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: the involvement of ERK1/2 and PKC.
This study investigated the protection of baicalin and its aglycone baicalein against APAP-induced hepatotoxicity and its mechanism. Baicalein and baicalin alleviated APAP-induced hepatotoxicity both in vitro and in vivo. Moreover, baicalin-provided this protection was not diminished in hepatocytes or mice treated with β-glucuronidase inhibitor. Results of liver glutathione (GSH) and reactive oxygen species (ROS) formation demonstrated the alleviation of baicalein and baicalin on APAP-induced liver oxidative stress injury. Baicalein and baicalin induced the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) ...
Source: Biochemical Pharmacology - January 12, 2018 Category: Drugs & Pharmacology Authors: Shi L, Hao Z, Zhang S, Wei M, Lu B, Wang Z, Ji L Tags: Biochem Pharmacol Source Type: research

Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin.
In conclusion, this study clearly defines the cell source of OPN induction in response to APAP treatment, provides a novel insight into the metabolic role of OPN to APAP overdose, and suggests an Opn-targeted therapeutic strategy for the treatment or prevention of APAP-induced hepatotoxicity. PMID: 29735980 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Immunology - May 7, 2018 Category: Molecular Biology Authors: Wen Y, Wang C, Gu J, Yu C, Wang K, Sun X, Sun Y, Wu H, Tong Y, Xia Q, Kong X Tags: Cell Mol Immunol Source Type: research

Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro
In conclusion, Rg1 produced hepatoprotective effects against APAP-induced acute liver injury via Nrf2 signaling pathway. Rg1 might be an effective approach for the prevention against acute liver injury.Graphical abstract
Source: Regulatory Toxicology and Pharmacology - July 18, 2018 Category: Toxicology Source Type: research

Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
In conclusion, Rg1 produced hepatoprotective effects against APAP-induced acute liver injury via Nrf2 signaling pathway. Rg1 might be an effective approach for the prevention against acute liver injury. PMID: 30030101 [PubMed - as supplied by publisher]
Source: Regulatory Toxicology and Pharmacology : RTP - July 17, 2018 Category: Toxicology Authors: Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K Tags: Regul Toxicol Pharmacol Source Type: research

Why Do Birds Flock? A Role for Opioids in the Reinforcement of Gregarious Social Interactions
Conclusion We propose that studies of songbirds reveal a novel network model for the integration of positive and negative reinforcement processes in non-sexual affiliative social behavior. Most studies on affiliative behavior focus on the positive affective state induced by social contact that rewards individuals interacting together. However, this review highlights that in social animals, affiliative contact is also reinforced because it reduces a negative affective state caused by social exclusion or isolation, thus creating a complementary system (i.e., positive reinforcement from affiliative interactions and negative ...
Source: Frontiers in Physiology - April 11, 2019 Category: Physiology Source Type: research

Chrysanthemum extract attenuates hepatotoxicity via inhibiting oxidative stress in vivo and in vitro.
Conclusions: BZE plays an important role in preventing hepatotoxicity by inhibiting oxidative stress and apoptosis through activation of Nrf2 signaling. BZE could be developed as an effective functional food for protecting the liver. PMID: 31024225 [PubMed]
Source: Food and Nutrition Research - April 27, 2019 Category: Nutrition Authors: Tian Z, Jia H, Jin Y, Wang M, Kou J, Wang C, Rong X, Xie X, Han G, Pang X Tags: Food Nutr Res Source Type: research

TLR4 promotes liver inflammation by activating the JNK pathway.
CONCLUSIONS: APAP-treated TLR4-/- mice showed milder liver injury compared to WT mice. It was confirmed that TLR4 could activate the JNK signaling pathway to induce the secretion of inflammatory factors and the infiltration of macrophages to promote APAP-induced liver injury. This finding might provide a new prevention and treatment idea for clinical drug-induced hepatitis. PMID: 31539158 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - September 22, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research