Filtered By:
Countries: Japan Health

This page shows you your search results in order of date. This is page number 8.

Order by Relevance | Date

Total 117 results found since Jan 2013.

Exosomes Derived from Cancer Associated Fibroblasts Elicit Survival and Drug Resistance of Primary Lymphoma Cells
ConclusionOur results suggest that CAFs and exosomes secreted from them are involved in the survival and drug resistance of patient lymphoma cells and play a pivotal role in the microenvironment of non-Hodgkin lymphoma. Exosomes would be a novel attractive therapeutic target.DisclosuresKiyoi: Sanofi K.K.: Research Funding; Kyowa Hakko Kirin Co., Ltd.: Research Funding; Otsuka Pharmaceutical Co., Ltd.: Research Funding; Nippon Shinyaku Co., Ltd.: Research Funding; Celgene Corporation: Research Funding; Zenyaku Kogyo Co., Ltd.: Research Funding; Eisai Co., Ltd.: Research Funding; FUJIFILM Corporation: Research Funding; Chuga...
Source: Blood - November 21, 2018 Category: Hematology Authors: Kunou, S., Shimada, K., Hikita, T., Aoki, T., Sakamoto, A., Hayakawa, F., Oneyama, C., Kiyoi, H. Tags: 622. Lymphoma Biology-Non-Genetic Studies: Poster III Source Type: research

Shikonin Suppresses Lymphangiogenesis via NF- κB/HIF-1α Axis Inhibition.
In conclusion, shikonin inhibits lymphangiogenesis in vitro by interfering the NF-κB/HIF-1α pathway and involves in suppression of VEGF-C and VEGFR-3 mRNA expression. PMID: 30381665 [PubMed - in process]
Source: Biological and Pharmaceutical Bulletin - November 2, 2018 Category: Drugs & Pharmacology Authors: Prangsaengtong O, Jantaree P, Lirdprapamongkol K, Svasti J, Koizumi K Tags: Biol Pharm Bull Source Type: research

Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1 α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells
ConclusionDEC2 could upregulate retinalVEGF gene expression through modulation of HIF1 α levels under hypoxic conditions.
Source: Japanese Journal of Ophthalmology - September 24, 2018 Category: Opthalmology Source Type: research

Ethanol Extract of Lycopus lucidus Turcz. ex Benth Inhibits Metastasis by Downregulation of Runx-2 in Mouse Colon Cancer Cells.
This study aims to elucidate the effects of ethanol extracts of LT (ELT) relative to the role of Runt-related transcription factor- (Runx-) 2 in the invasive and metastatic potentials of mouse colon cancer to determine the underlying mechanisms involved. ELT was evaluated for the antimetastasis activity using CT-26 colon cancer using wound healing, transwell matrigel, and western blot analysis. We used Runx-2-specific siRNA to further determine the relationship between Runx-2 and matrix metalloprotease- (MMP-) 9 in the migration and invasion of CT-26 cells. Runx-2 was first demonstrated to be a transcription factor that pl...
Source: Evidence-based Complementary and Alternative Medicine - August 16, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Development of Noninvasive Drug Delivery Systems to the Brain for the Treatment of Brain/Central Nervous System Diseases.
Abstract 　In general, the blood-brain barrier (BBB) poses a major challenge to drug development efforts targeting brain/central nervous system (CNS) diseases, since it limits the distribution of systemically administered therapeutics to the brain/ CNS. Therefore, the development of effective strategies for enhancing drug delivery to the brain has been a topic of great interest in both the clinical and pharmaceutical fields. Intranasal administration has been noted as a method for noninvasive delivery of a drug to the brain/CNS by bypassing the BBB via the "nose-to-brain" route. This nose-to-brain delivery system...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 4, 2018 Category: Drugs & Pharmacology Authors: Kanazawa T Tags: Yakugaku Zasshi Source Type: research

Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl − /water secretion that involves cAMP-dependent activation of CFTR
AbstractConstipation is a common symptom frequently compromising the quality of daily life. Several mechanistically different drugs have been used to mitigate constipation, including Japanese herbal (Kampo) medicines. However, the mechanisms of their actions are often not well understood. Here we aimed to investigate the molecular mechanisms underlying the effects of Junchoto (JCT), a Kampo medicine empirically prescribed for chronic constipation. Cl− channel activity was measured by the patch-clamp method in human cystic fibrosis transmembrane conductance regulator (CFTR)-expressing HEK293T cells and human intestinal Ca...
Source: Journal of Natural Medicines - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Novel Anticancer Strategy Targeting Switch Mechanisms in Two Types of Cell Death: Necrosis and Apoptosis.
Abstract  Two types of cell death, necrosis and apoptosis, are defined in terms of cell death morphological features. We have been studying the mechanisms by which cell death processes are switched during the treatment of mouse tumor FM3A with anticancer, 5-fluoro-2'-deoxyuridine (FUdR): it induces original clone F28-7 to necrosis, but its sub-clone F28-7-A to apoptosis. We identified several such switch regulators of cell death: heat shock protein 90 (HSP90), lamin-B1, cytokeratin-19, and activating transcription factor 3 (ATF3), by using transcriptomic, proteomic analyses and siRNA screening. For example, the ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 4, 2017 Category: Drugs & Pharmacology Authors: Sato A Tags: Yakugaku Zasshi Source Type: research

European Society of Cardiology (ESC) Annual Congress Report From Barcelona 2017.
This report briefly introduces some late-breaking registry results, late-breaking clinical trials, and ESC Guidelines from the ESC 2017 Congress. PMID: 29093432 [PubMed - as supplied by publisher]
Source: Circulation Journal - November 2, 2017 Category: Cardiology Authors: Satoh K, Takahashi J, Matsumoto Y, Tatebe S, Aoki T, Kikuchi Y, Hao K, Ohyama K, Nogi M, Suda A, Kasahara S, Sato K, Ichijo S, Shimokawa H Tags: Circ J Source Type: research

A fast and efficient protocol for small RNA extraction in Japanese plum and other Prunus species
Conclusion We propose this protocol as a reliable and reproducible small RNA isolation procedure for P. salicina and other Prunus species.
Source: Electronic Journal of Biotechnology - October 17, 2017 Category: Biotechnology Source Type: research

PCSK9 inhibition in the management of familial hypercholesterolemia.
Abstract Familial hypercholesterolemia (FH) is a frequent hereditary metabolic disease characterized by high serum low-density lipoprotein (LDL) cholesterol concentration and premature atherosclerotic cardiovascular disease (ASCVD). The discovery of the LDL receptor as one of the causative genes of FH enabled us to understand the pathophysiology of FH and paved the way for developing statins. Similar to LDL receptor, discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) also created an opportunity for developing its inhibitors. Since PCSK9 degrades LDL receptor protein, inhibiting PCSK9 will be an eff...
Source: Journal of Cardiology - August 4, 2017 Category: Cardiology Authors: Ogura M Tags: J Cardiol Source Type: research

miR-582-5p inhibits invasion and migration of salivary adenoid cystic carcinoma cells by targeting FOXC1
ConclusionsmiR-582-5p could suppress effect on the process of invasion and migration in SACC cell lines, and this could occur through its target gene FOXC1.
Source: Japanese Journal of Clinical Oncology - June 7, 2017 Category: Cancer & Oncology Source Type: research