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Total 117 results found since Jan 2013.
Mycobacterium tuberculosis Rv2653 protein promotes inflammation response by enhancing glycolysis
Jpn J Infect Dis. 2023 Jul 31. doi: 10.7883/yoken.JJID.2022.647. Online ahead of print.ABSTRACTMycobacterium tuberculosis (M.tb) infection caused communicable disease tuberculosis (TB) is a major cause of ill health and one of the leading causes of death worldwide. Protein encoded by region of deletion (RD) of M.tb mediated the pathogenic properties of M.tb through inducing inflammation response or disrupting host cell metabolism. We cloned and purified Rv2653 protein from RD13 to explore its regulatory effect on host macrophages. We found Rv2653 protein promoted the glycolysis level and upregulated the expression of glyco...
Source: Japanese Journal of Infectious Diseases - July 30, 2023 Category: Infectious Diseases Authors: Yaman Du Rui Zheng Hongli Yin Li Ma Jingfang Li Yun Chen Xi Zhang Pengzuo Tao Lili Gao Li Yang Liang He Source Type: research
Seeking an Important Role on Metabolomics-Effects of β-Estradiol on Lipoprotein Metabolism in Mammary Tumors
Yakugaku Zasshi. 2022;142(11):1191-1199. doi: 10.1248/yakushi.22-00098.ABSTRACTThe role of β-estradiol (E2) in lipoprotein metabolism in mammary tumors remains unknown. Therefore the effect of E2 on secretion of lipoprotein lipase (LPL) from mouse mammary tumor FM3A cells was examined. The E2-treated FM3A cells increased active LPL secretion in a time- and dose-dependent manner. The activity of mitogen-activated protein kinase (MAPK) was elevated in the tumor cells treated with E2, and E2-stimulated secretion of LPL was suppressed by the MAPK kinase 1/2 inhibitor PD98059, extracellular signal-regulated kinase (ERK) 1/2 in...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 3, 2022 Category: Drugs & Pharmacology Authors: Tetsuo Morita Source Type: research
