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Mycobacterium tuberculosis Rv2653 protein promotes inflammation response by enhancing glycolysis
Jpn J Infect Dis. 2023 Jul 31. doi: 10.7883/yoken.JJID.2022.647. Online ahead of print.ABSTRACTMycobacterium tuberculosis (M.tb) infection caused communicable disease tuberculosis (TB) is a major cause of ill health and one of the leading causes of death worldwide. Protein encoded by region of deletion (RD) of M.tb mediated the pathogenic properties of M.tb through inducing inflammation response or disrupting host cell metabolism. We cloned and purified Rv2653 protein from RD13 to explore its regulatory effect on host macrophages. We found Rv2653 protein promoted the glycolysis level and upregulated the expression of glyco...
Source: Japanese Journal of Infectious Diseases - July 30, 2023 Category: Infectious Diseases Authors: Yaman Du Rui Zheng Hongli Yin Li Ma Jingfang Li Yun Chen Xi Zhang Pengzuo Tao Lili Gao Li Yang Liang He Source Type: research