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Total 117 results found since Jan 2013.
Seeking an Important Role on Metabolomics-Effects of β-Estradiol on Lipoprotein Metabolism in Mammary Tumors
Yakugaku Zasshi. 2022;142(11):1191-1199. doi: 10.1248/yakushi.22-00098.ABSTRACTThe role of β-estradiol (E2) in lipoprotein metabolism in mammary tumors remains unknown. Therefore the effect of E2 on secretion of lipoprotein lipase (LPL) from mouse mammary tumor FM3A cells was examined. The E2-treated FM3A cells increased active LPL secretion in a time- and dose-dependent manner. The activity of mitogen-activated protein kinase (MAPK) was elevated in the tumor cells treated with E2, and E2-stimulated secretion of LPL was suppressed by the MAPK kinase 1/2 inhibitor PD98059, extracellular signal-regulated kinase (ERK) 1/2 in...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 3, 2022 Category: Drugs & Pharmacology Authors: Tetsuo Morita Source Type: research
Fundamental Studies on Development of Next-generation Medium Sized Peptide Drugs
Yakugaku Zasshi. 2022;142(10):1061-1066. doi: 10.1248/yakushi.22-00115.ABSTRACTMedium-sized peptides are expected as a next-generation drug discovery modality because they combine the properties of conventional small-molecule drugs and biopharmaceuticals. Nonetheless, peptides are easily degraded by digestive enzymes such as protease in the body, which could be problematic for the development of peptide-based drugs. To overcome such a problem, peptide-based foldamers containing non-proteinogenic amino acids or cyclized peptides have been reported. In addition, peptides must form stable secondary structures and their side c...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 2, 2022 Category: Drugs & Pharmacology Authors: Takashi Misawa Source Type: research
