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Condition: Allergy

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Total 196 results found since Jan 2013.

Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome.
Abstract Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the present study was to investigate Der f1, an allergen of Dermatophagoides farinae, which may result in the death of human bronchial epithelial cells (HBECs). Der f1 induces BECs to undergo the inflammatory cell death referred to as pyroptosis, induced by increasing lactate dehydrogenase rele...
Source: International Journal of Molecular Medicine - December 5, 2017 Category: Molecular Biology Authors: Tsai YM, Chiang KH, Hung JY, Chang WA, Lin HP, Shieh JM, Chong IW, Hsu YL Tags: Int J Mol Med Source Type: research

Alteration in Claudin-4 Contributes to Airway Inflammation and Responsiveness in Asthma.
CONCLUSIONS: These findings thus raise the possibility that regulation of lung epithelial barrier proteins may constitute a therapeutic approach for asthma. PMID: 29178675 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 29, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Regulation of claudin ‐4 via p63 in human epithelial cells
P63 is a regulator of cell–cell junction complexes in the epidermis. Claudin‐4 is regulated via various factors in normal epithelial cells and diseases. We found that claudin‐4 was directly regulated via p63 (TAp63 and ΔNp63) in human keratinocytes and nasal epithelial cells. In the epidermis of atopic dermatitis (AD), which contains ΔNp63‐deficient keratinocytes, high expression of claudin‐4 was observed. In primary keratinocytes, downregulation of ΔNp63 by treatment with short interfering RNA (siRNA)‐p63 induced claudin‐4 expression. In nasal epithelial cells in the context of rhinitis or nasal polyps, u...
Source: Annals of the New York Academy of Sciences - July 1, 2017 Category: Science Authors: Takashi Kojima, Takayuki Kohno, Terufumi Kubo, Yakuto Kaneko, Takuya Kakuki, Akito Kakiuchi, Makoto Kurose, Ken ‐ichi Takano, Noriko Ogasawara, Kazufumi Obata, Kazuaki Nomura, Ryo Miyata, Takumi Konno, Shingo Ichimiya, Tetsuo Himi Tags: REVIEW Source Type: research

Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions
This study aims to determine the mechanism of cimifugin on epithelial cells in allergic inflammation. Mice were sensitized and challenged with FITC to establish type 2 atopic dermatitis (AD) model. The initial stage of AD model, in which mice were just sensitized with FITC, was established in vivo and immortalized human epidermal (HaCaT) cells were utilized in vitro. Initiative key cytokines, TSLP and IL‐33, were measured by ELISA, the junctions in ECs were observed by electron microscopy and TJs (CLDN‐1, occludin and CLDND1) were assessed by Western blot, immunohistochemistry and immunofluorescence. The results show...
Source: Journal of Cellular and Molecular Medicine - June 9, 2017 Category: Molecular Biology Authors: Xiaoyu Wang, Xiaoyan Jiang, Xi Yu, Hailiang Liu, Yu Tao, Guorong Jiang, Min Hong Tags: Original Article Source Type: research

Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions.
This study aims to determine the mechanism of cimifugin on epithelial cells in allergic inflammation. Mice were sensitized and challenged with FITC to establish type 2 atopic dermatitis (AD) model. The initial stage of AD model, in which mice were just sensitized with FITC, was established in vivo and immortalized human epidermal (HaCaT) cells were utilized in vitro. Initiative key cytokines, TSLP and IL-33, were measured by ELISA, the junctions in ECs were observed by electron microscopy and TJs (CLDN-1, occludin and CLDND1) were assessed by Western blot, immunohistochemistry and immunofluorescence. The results showed t...
Source: J Cell Mol Med - June 9, 2017 Category: Molecular Biology Authors: Wang X, Jiang X, Yu X, Liu H, Tao Y, Jiang G, Hong M Tags: J Cell Mol Med Source Type: research

Heme oxygenase ‐1 directly binds STAT3 to control the generation of pathogenic Th17 cells during neutrophilic airway inflammation
ConclusionsOur data suggest that HO‐1 exerts its inhibitory effect on Th17 cell differentiation by directly associating and blocking STAT3 phosphorylation. We speculate that hemin may be a potential therapeutic candidate for the treatment of other types of immune and pulmonary inflammatory‐related diseases.This article is protected by copyright. All rights reserved.
Source: Allergy - June 5, 2017 Category: Allergy & Immunology Authors: Xiaoliang Lin, Jiajia Lv, Jie Lv, Caixia Di, Yanjie Zhang, Tong Zhou, Junling Liu, Zhenwei Xia Tags: Original Article: Airway Diseases Source Type: research

Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis
Conclusions Our data identify TWIST1 as a central pro-fibrotic factor in SSc, which facilitates fibroblast activation by amplifying TGFβ signalling. Targeting of TWIST1 may thus be a novel approach to normalise aberrant TGFβ signalling in SSc.
Source: Annals of the Rheumatic Diseases - December 8, 2016 Category: Rheumatology Authors: Palumbo-Zerr, K., Soare, A., Zerr, P., Liebl, A., Mancuso, R., Tomcik, M., Sumova, B., Dees, C., Chen, C.-W., Wohlfahrt, T., Mallano, T., Distler, A., Ramming, A., Gelse, K., Mihai, C., Distler, O., Schett, G., Distler, J. H. W. Tags: Immunology (including allergy), Connective tissue disease Basic and translational research Source Type: research

Neuronal Fc-epsilon receptor I contributes to antigen-evoked pruritus in a murine model of ocular allergy.
This study may suggest a novel mechanism for the development of pathological itch in allergic diseases. PMID: 27865948 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - November 15, 2016 Category: Neurology Authors: Liu F, Xu L, Chen N, Zhou M, Li C, Yang Q, Xie Y, Huang Y, Ma C Tags: Brain Behav Immun Source Type: research

Neuronal Fc-epsilon receptor I contributes to antigen-evoked pruritus in a murine model of ocular allergy
This study may suggest a novel mechanism for the development of pathological itch in allergic diseases.
Source: Brain, Behavior, and Immunity - November 15, 2016 Category: Neurology Source Type: research

Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis
Conclusions Macrophage response to MTX is polarisation-dependent and determined by the TS-p53 axis. CCL20 and LIF constitute novel macrophage markers for MTX responsiveness in vitro.
Source: Annals of the Rheumatic Diseases - November 9, 2016 Category: Rheumatology Authors: Municio, C., Soler Palacios, B., Estrada-Capetillo, L., Benguria, A., Dopazo, A., Garcia-Lorenzo, E., Fernandez-Arroyo, S., Joven, J., Miranda-Carus, M. E., Gonzalez-Alvaro, I., Puig-Kröger, A. Tags: Immunology (including allergy), Inflammation, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research

Ribosomal protein S3 gene silencing protects against experimental allergic asthma
We reported here for the first time that RPS3 gene silencing ameliorates experimental allergic asthma, probably via interruption of NF-B activity, confirming RPS3 a novel therapeutic target for the treatment of allergic airway inflammation.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Dong, J., Liao, W., Peh, H. Y., Chan, T. K., Tan, W. S. D., Li, L., Wong, W. S. F. Tags: 5.3 Allergy and Immunology Source Type: research

Escherichia coli –derived and Staphylococcus aureus–derived extracellular vesicles induce MUC5AC expression via extracellular signal related kinase 1/2 and p38 mitogen‐activated protein kinase in human airway epithelial cells
ConclusionThe results of this study suggest that E. coli–derived and S. aureus–derived EVs induced MUC5AC expression via ERK1/2 and p38 MAPK signaling pathways in human airway epithelial cells.
Source: International Forum of Allergy and Rhinology - August 31, 2016 Category: Allergy & Immunology Authors: Chang Hoon Bae, Yoon Seok Choi, Si ‐Youn Song, Yoon‐Keun Kim, Yong‐Dae Kim Tags: ORIGINAL ARTICLE Source Type: research

Epigenetic determinants of allergy and tolerance
SummaryNot only genetics and environmental factors are responsible for the development of allergies. Epigenetic mechanisms — that are master regulators of gene transcription and thus of the accessibility and use of genome information — have been identified as a third power that is key in determining many features of allergy. So far, three epigenetic mechanisms have been identified in humans: histone modification, DN A methylation, and posttranscriptional modification by microRNA (miRNA) or small interferingRNA (siRNA). In recent years, it became clear that epigenetic regulation of gene function does not only play a rol...
Source: Allergo Journal International - August 31, 2016 Category: Allergy & Immunology Source Type: research

Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma
ConclusionsPP5‐dependent impairment of GRα function represents a novel mechanism driving GC insensitivity in ASM in severe asthma.This article is protected by copyright. All rights reserved.
Source: Allergy - August 9, 2016 Category: Allergy & Immunology Authors: Latifa Chachi, Mahnaz Abbassian, Adelina Gavrila, Abdulrahman Alzahrani, Omar Tliba, Peter Bradding, Andrew J. Wardlaw, Christopher Brightling, Yassine Amrani Tags: Original Article: Airway Diseases Source Type: research

Synergistic Effect of Dermatophagoides farinae and Lipopolysaccharides in Human Middle ear Epithelial Cells.
CONCLUSIONS: When Der f treatment preceded LPS exposure, Der f and LPS acted synergistically in the induction of pro-inflammatory cytokines and the MUC gene, suggesting an important role in the development of OME in patients with concealed allergy airway sensitization. PMID: 27334783 [PubMed]
Source: Allergy, Asthma and Immunology Research - June 24, 2016 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research