Heme oxygenase ‐1 directly binds STAT3 to control the generation of pathogenic Th17 cells during neutrophilic airway inflammation

ConclusionsOur data suggest that HO‐1 exerts its inhibitory effect on Th17 cell differentiation by directly associating and blocking STAT3 phosphorylation. We speculate that hemin may be a potential therapeutic candidate for the treatment of other types of immune and pulmonary inflammatory‐related diseases.This article is protected by copyright. All rights reserved.

Source: Allergy - June 5, 2017 Category: Allergy & Immunology Authors: Xiaoliang Lin, Jiajia Lv, Jie Lv, Caixia Di, Yanjie Zhang, Tong Zhou, Junling Liu, Zhenwei Xia Tags: Original Article: Airway Diseases Source Type: research