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Condition: Allergy

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Total 196 results found since Jan 2013.

TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.
Conclusion and Clinical RelevanceImpaired antiviral responses in asthmatic pBECs are not due to deficient expression of PRRs; MDA5 and TLR3, but an inability to later activate types I and III interferon immune responses to RV infection, potentially increasing susceptibility to the effects of RV infection.
Source: Clinical and Experimental Allergy - December 20, 2013 Category: Allergy & Immunology Authors: K. S. Parsons, A. C. Hsu, P. A. B. Wark Tags: Original Article Source Type: research

Epigallocatechin-3-Gallate Prevents Autoimmune-Associated Down-Regulation of p21 in Salivary Gland Cells Through a p53-Independent Pathway.
In conclusion, PCNA and p21 levels are altered inversely in the NOD model for SS and in HSG cells, and warrant further study as candidate new markers for salivary dysfunction associated with xerostomia. Induction of p21 by EGCG could provide clinically useful normalization of salivary glands by promoting differentiation and reducing PCNA levels. PMID: 24329914 [PubMed - as supplied by publisher]
Source: Inflammation and Allergy Drug Targets - December 10, 2013 Category: Allergy & Immunology Authors: Dickinson D, Yu H, Ohno S, Thomas C, Derossi S, Yat-Ho M, Yates N, Hahn E, Bisch F, Yamamoto T, Hsu S Tags: Inflamm Allergy Drug Targets Source Type: research

TLR3 and MDA5 signalling though not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection
Conclusion & Clinical RelevanceImpaired antiviral responses in asthmatic pBECs are not due to deficient expression of PRRs; MDA5 and TLR3, but an inability to later activate type I and III interferon immune responses to RV infection, potentially increasing susceptibility to the effects of RV infection.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - October 17, 2013 Category: Allergy & Immunology Authors: Kristy S Parsons, Alan C Hsu, Peter AB Wark Tags: Original Article‐Experimental Models of Allergic Disease Source Type: research

Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin‐β1
ConclusionsFibroblast‐derived membranes, integrin‐β1, and Hck are involved in MBP1‐induced activation of CBMC and therefore represent a distinct mechanism for this activation. This finding might implicate integrin‐β1 and Hck as targets for decreasing MC – Eos activating cross‐talk in allergy.
Source: Allergy - September 21, 2013 Category: Allergy & Immunology Authors: M. Ben‐Zimra, I. Bachelet, M. Seaf, G. J. Gleich, F. Levi‐Schaffer Tags: Original Article Source Type: research

Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes
Conclusions These data suggest that AHR antagonism may represent a viable adjuvant therapeutic strategy for the amelioration of inflammation associated with RA.
Source: Annals of the Rheumatic Diseases - September 4, 2013 Category: Rheumatology Authors: Lahoti, T. S., John, K., Hughes, J. M., Kusnadi, A., Murray, I. A., Krishnegowda, G., Amin, S., Perdew, G. H. Tags: Immunology (including allergy), Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Epidemiology Basic and translational research Source Type: research

Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis
Conclusions Our results show that the expression of NAMPT in Ly6Chigh monocytes promotes many downstream effects involved in inflammatory arthritis and demonstrate the utility of targeting disease-causing genes, such as NAMPT, in Ly6Chigh monocytes for therapeutic intervention in arthritis.
Source: Annals of the Rheumatic Diseases - September 4, 2013 Category: Rheumatology Authors: Presumey, J., Courties, G., Louis-Plence, P., Escriou, V., Scherman, D., Pers, Y.-M., Yssel, H., Pene, J., Kyburz, D., Gay, S., Jorgensen, C., Apparailly, F. Tags: Genetics, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research

Differential expression of 11β‐hydroxysteroid dehydrogenase type 1 and 2 in mild and moderate/severe persistent allergic nasal mucosa and regulation of their expression by Th2 cytokines
Conclusions and Clinical RelevanceThese results indicate that the localized anti‐inflammatory effects of glucocorticoids are regulated by inflammatory cytokines, which can modulate the expression of 11β‐HSD1, 11β‐HSD2, CYP11B1, and by the intracellular concentrations of bioactive glucocorticoids.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - September 1, 2013 Category: Allergy & Immunology Authors: Young Joon Jun, Se Jin Park, Jae Woong Hwang, Tae Hoon Kim, Kwang Jin Jung, Jong Yoon Jung, Gyu Ho Hwang, Seung Hoon Lee, Sang Hag Lee Tags: Original Article‐Basic Mechanisms in Allergic Disease Source Type: research

A new nucleic acid–based agent inhibits cytotoxic T lymphocyte–mediated immune disorders
Conclusions: Our results identified a new nucleic acid–based agent (CD8 aptamer–GNLY siRNA chimera) that can significantly inhibit CTL-mediated drug hypersensitivity, such as that seen in patients with SJS/TEN, as well as the alloreactivity seen in patients with GVHD. This study provides a novel therapeutic strategy for CTL-mediated immune disorders.
Source: Journal of Allergy and Clinical Immunology - June 21, 2013 Category: Allergy & Immunology Authors: Chuang-Wei Wang, Wen-Hung Chung, Yi-Fang Cheng, Nien-Wen Ying, Konan Peck, Yuan-Tsong Chen, Shuen-Iu Hung Tags: Mechanisms of allergy and clinical immunology Source Type: research

Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2
Conclusions Notch-1 mediates VEGF/Ang2-induced angiogenesis and EC invasion in inflammatory arthritis.
Source: Annals of the Rheumatic Diseases - May 10, 2013 Category: Rheumatology Authors: Gao, W., Sweeney, C., Walsh, C., Rooney, P., McCormick, J., Veale, D. J., Fearon, U. Tags: Open access, Immunology (including allergy), Pathology, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Surgical diagnostic tests, Clinical diagnostic tests Basic and translational research Source Type: research

Herpesviruses and the microbiome
The focus of this article will be to examine the role of common herpesviruses as a component of the microbiome of atopic patients and to review clinical observations suggesting that atopic patients might be predisposed to more severe and atypical herpes-related illness because their immune response is biased toward a TH2 cytokine profile. Human populations are infected with 8 herpesviruses, including herpes simplex virus HSV1 and HSV2 (also termed HHV1 and HHV2), varicella zoster virus (VZV or HHV3), EBV (HHV4), cytomegalovirus (HHV5), HHV6, HHV7, and Kaposi sarcoma–associated herpesvirus (termed KSV or HHV8). Herpesviru...
Source: Journal of Allergy and Clinical Immunology - April 22, 2013 Category: Allergy & Immunology Authors: David H. Dreyfus Tags: Rostrum Source Type: research

AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice
Conclusions: The Fyn-regulated LKB1-AMPK axis acts as a novel inhibitory module for mast cell activation, which points to AMPK activators as therapeutic drugs for allergic diseases.
Source: Journal of Allergy and Clinical Immunology - April 15, 2013 Category: Allergy & Immunology Authors: Seung-Lark Hwang, Xian Li, Yue Lu, Ye Jin, Yong-Tae Jeong, Yong Deuk Kim, In-Kyu Lee, Yoshitaka Taketomi, Hiroyasu Sato, You Sook Cho, Makoto Murakami, Hyeun Wook Chang Tags: Mechanisms of allergy and clinical immunology Source Type: research

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis
Conclusions These data demonstrate a novel role of H3 Lys27 histone methylation in fibrosis. In contrast to other epigenetic modifications such as DNA methylation and histone acetylation, H3 Lys27 histone methylation acts as a negative regulator of fibroblast activation in vitro and in vivo by repressing the expression of fra-2.
Source: Annals of the Rheumatic Diseases - February 25, 2013 Category: Rheumatology Authors: Kramer, M., Dees, C., Huang, J., Schlottmann, I., Palumbo-Zerr, K., Zerr, P., Gelse, K., Beyer, C., Distler, A., Marquez, V. E., Distler, O., Schett, G., Distler, J. H. W. Tags: Immunology (including allergy), Connective tissue disease Basic and translational research Source Type: research

Curcumin induces apoptotic cell death of activated human CD4+ T cells via increasing endoplasmic reticulum stress and mitochondrial dysfunction.
Abstract Curcumin, a natural polyphenolic antioxidant compound, exerts well-known anti-inflammatory and immunomodulatory effects, the latter which can influence the activation of immune cells including T cells. Furthermore, curcumin can inhibit the expression of pro-inflammatory cytokines and chemokines, through suppression of the NF-κB signaling pathway. The beneficial effects of curcumin in diseases such as arthritis, allergy, asthma, atherosclerosis, diabetes and cancer may be due to its immunomodulatory properties. We studied the potential of curcumin to modulate CD4+ T cells-mediated autoimmune disease, by e...
Source: International Immunopharmacology - February 14, 2013 Category: Allergy & Immunology Authors: Zheng M, Zhang Q, Joe Y, Lee BH, Ryu DG, Kwon KB, Ryter SW, Chung HT Tags: Int Immunopharmacol Source Type: research