TLR3 and MDA5 signalling though not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection

Conclusion & Clinical RelevanceImpaired antiviral responses in asthmatic pBECs are not due to deficient expression of PRRs; MDA5 and TLR3, but an inability to later activate type I and III interferon immune responses to RV infection, potentially increasing susceptibility to the effects of RV infection.This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fcea.12218

Source: Clinical and Experimental Allergy - October 17, 2013 Category: Allergy & Immunology Authors: Kristy S Parsons, Alan C Hsu, Peter AB Wark Tags: Original Article‐Experimental Models of Allergic Disease Source Type: research