Differential expression of 11β‐hydroxysteroid dehydrogenase type 1 and 2 in mild and moderate/severe persistent allergic nasal mucosa and regulation of their expression by Th2 cytokines

Conclusions and Clinical RelevanceThese results indicate that the localized anti‐inflammatory effects of glucocorticoids are regulated by inflammatory cytokines, which can modulate the expression of 11β‐HSD1, 11β‐HSD2, CYP11B1, and by the intracellular concentrations of bioactive glucocorticoids.This article is protected by copyright. All rights reserved.

Source: Clinical and Experimental Allergy - September 1, 2013 Category: Allergy & Immunology Authors: Young Joon Jun, Se Jin Park, Jae Woong Hwang, Tae Hoon Kim, Kwang Jin Jung, Jong Yoon Jung, Gyu Ho Hwang, Seung Hoon Lee, Sang Hag Lee Tags: Original Article‐Basic Mechanisms in Allergic Disease Source Type: research