Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin‐β1

ConclusionsFibroblast‐derived membranes, integrin‐β1, and Hck are involved in MBP1‐induced activation of CBMC and therefore represent a distinct mechanism for this activation. This finding might implicate integrin‐β1 and Hck as targets for decreasing MC – Eos activating cross‐talk in allergy.

Source: Allergy - September 21, 2013 Category: Allergy & Immunology Authors: M. Ben‐Zimra, I. Bachelet, M. Seaf, G. J. Gleich, F. Levi‐Schaffer Tags: Original Article Source Type: research