AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice

Conclusions: The Fyn-regulated LKB1-AMPK axis acts as a novel inhibitory module for mast cell activation, which points to AMPK activators as therapeutic drugs for allergic diseases.

Source: Journal of Allergy and Clinical Immunology - April 15, 2013 Category: Allergy & Immunology Authors: Seung-Lark Hwang, Xian Li, Yue Lu, Ye Jin, Yong-Tae Jeong, Yong Deuk Kim, In-Kyu Lee, Yoshitaka Taketomi, Hiroyasu Sato, You Sook Cho, Makoto Murakami, Hyeun Wook Chang Tags: Mechanisms of allergy and clinical immunology Source Type: research