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Condition: Allergy
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Total 196 results found since Jan 2013.
Effect of Neurokinin-1 Receptor Knockdown on the Expression of RANTES in Allergic Rhinitis
Am J Rhinol Allergy. 2023 Jul 31:19458924231191012. doi: 10.1177/19458924231191012. Online ahead of print.ABSTRACTBACKGROUND: Neurokinin-1 receptor (NK-1R) and normal T cell expressed and secreted (RANTES) have been shown to play important roles in allergic rhinitis (AR). However, whether the regulating effect of NK-1R in AR is achieved via RANTES remains unknown.METHODS: In the present study, Sprague-Dawley rats were sensitized and challenged with ovalbumin to make AR models. During the challenge period, the rats were treated intranasally with NK-1R-specific small interfering RNA (siRNA) for NKR group, negative siRNA for ...
Source: American Journal of Rhinology and Allergy - August 1, 2023 Category: ENT & OMF Authors: Hong Wang Jing Wu Ruxin Zhang Source Type: research
Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway
CONCLUSIONS: Increased sputum CST1 may play a key role in the pathogenesis of asthma through involvement in eosinophilic and type 2 inflammation through activation of the AKT signaling pathway, further promoting SERPINB2 expression. Therefore, targeting CST1 might be of therapeutic value in treating asthma with severe and eosinophilic phenotypes.PMID:37075800
Source: Allergy, Asthma and Immunology Research - April 19, 2023 Category: Allergy & Immunology Authors: Lijuan Du Changyi Xu Kun Tang Jia Shi Lu Tang Xiao Lisha Chengcheng Lei Huicong Liu Yuxia Liang Yubiao Guo Source Type: research
MiR-214 Expression Is Elevated in Chronic Rhinosinusitis Mucosa and Regulates Lipopolysaccharide-Mediated Responses in Undifferentiated Human Nasal Epithelial Cell Culture
CONCLUSION: Taken together, miR-214 regulates LPS-mediated inflammation and MUC5AC expression via targeting SIRT1, and STAT3/GDF15 may involve in the regulation of miR-214 inhibitor on inflammation and MUC5AC expression.PMID:36797977 | DOI:10.1177/19458924231152683
Source: American Journal of Rhinology and Allergy - February 17, 2023 Category: ENT & OMF Authors: Zhou Wang Dong Lin Yuxiang Zhao Hui Liu Ting Yang An Li Source Type: research
