TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.

Conclusion and Clinical RelevanceImpaired antiviral responses in asthmatic pBECs are not due to deficient expression of PRRs; MDA5 and TLR3, but an inability to later activate types I and III interferon immune responses to RV infection, potentially increasing susceptibility to the effects of RV infection.

Source: Clinical and Experimental Allergy - December 20, 2013 Category: Allergy & Immunology Authors: K. S. Parsons, A. C. Hsu, P. A. B. Wark Tags: Original Article Source Type: research