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Condition: Sleep Disorders

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Total 41 results found since Jan 2013.

Globular adiponectin protects hepatocytes against intermittent hypoxia-induced injury via Pink1/Parkin-mediated mitophagy induction
ConclusiongAPN alleviated IH-induced mitochondrial injury and hepatocyte apoptosis by upregulating Pink1/Parkin-mediated mitophagy.
Source: Sleep and Breathing - October 26, 2021 Category: Respiratory Medicine Source Type: research

Melanopsin Signaling Pathway in HEK293 Cell Line with Stable Expression of Human Melanopsin: Possible Participation of Phospholipase C beta 4 and Diacylglycerol
AbstractMelanopsin, a member of the G-protein coupled receptors family, is involved in non-image-forming functions including circadian rhythm, sleep regulation, pupil response. In spite of significant research efforts, the signaling cascade involving melanopsin photoactivation remains poorly characterized. Here, we analyzed the effects of photoactivation of melanopsin on phospholipase C (PLC) and diacylglycerol. As anin vitro model, HEK293 cells with stable expression of human melanopsin were used. Although both the PLCβ1 and PLCβ4 subtypes were activated by the cell exposure to blue light, only PLCβ4 appeared to play a...
Source: Photochemistry and Photobiology - May 12, 2021 Category: Science Authors: Olga I. Krzysztynska ‐Kuleta, Magdalena M. Olchawa, Tadeusz J. Sarna Tags: RESEARCH ARTICLE Source Type: research

Circadian Rhythm Protein Bmal1 Modulates Cartilage Gene Expression in Temporomandibular Joint Osteoarthritis via the MAPK/ERK Pathway
The purpose of this study was to elucidate the role of the circadian gene Bmal1 in human cartilage and its crosstalk with the MAPK/ERK signaling pathway in temporomandibular joint osteoarthritis (TMJ-OA). We verified the periodical variation of the circadian gene Bmal1 and then established a modified multiple platform method (MMPM) to induce circadian rhythm disturbance leading to TMJ-OA. IL-6, p-ERK, and Bmal1 mRNA and protein expression levels were assessed by real-time RT-PCR and immunohistochemistry. Chondrocytes were treated with an ERK inhibitor (U0126), siRNA and plasmid targeting Bmal1 under IL-6 simulation; then, ...
Source: Frontiers in Pharmacology - September 17, 2020 Category: Drugs & Pharmacology Source Type: research

Hypoxia inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia.
Abstract The role of hypoxia-inducible factor (HIF)-1 in pancreatic β-cell response to intermittent hypoxia (IH) was examined. Studies were performed on adult wild type (WT), HIF-1α heterozygous (HET) as well as β-cell specific HIF-1-/- mice and mouse insulinoma (MIN6) cells exposed to IH patterned after blood O2 profiles during obstructive sleep apnea (OSA). WT mice treated with IH showed insulin resistance, and pancreatic β-cell dysfunction manifested as augmented basal insulin secretion, and impaired glucose stimulated insulin secretion (GSIS) and these effects were absent in HIF-1α HET mice. IH increased ...
Source: Am J Physiol Cell Ph... - September 15, 2020 Category: Cytology Authors: Wang N, Shi XF, Khan SA, Wang B, Semenza GL, Prabhakar NR, Nanduri J Tags: Am J Physiol Cell Physiol Source Type: research

Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2.
Abstract Sleep disorder has become a prevalent issue in current society and is connected with the deterioration of neurobehaviors such as mood, cognition and memory. Ellagic acid (EA) is a phenolic phytoconstituent extracted from grains and fruits that has potent neuroprotective properties. This research aimed to study the alleviative effect and mechanism of EA on memory impairment and anxiety caused by sleep deprivation (SD). EA ameliorated behavioral abnormalities in SD mice, associated with increased dendritic spine density, and reduced shrinkage and loss of hippocampal neurons. EA reduced the inflammatory resp...
Source: Aging - May 19, 2020 Category: Biomedical Science Authors: Wang W, Yang L, Liu T, Wang J, Wen A, Ding Y Tags: Aging (Albany NY) Source Type: research

Corilagin ameliorates sleep deprivation-induced memory impairments by inhibiting NOX2 and activating Nrf2.
Abstract Sleep deprivation (SD) can induce cognitive and memory impairments. This impairment is in part due to oxidative stress damage in the hippocampus region of the brain. Corilagin (CL), a polyphenol belonging to the tannin family and extracted from Terminalia chebula and Phyllanthus emblica, shows strong antioxidant and neuroprotective effects. NF-E2-related factor (Nrf2)/heme oxygenase-1 (HO-1) and NADPH oxidase (NOX) are critical targets involved in cellular defense mechanisms against oxidative injury. Thus, we hypothesized that CL could be a preventive treatment for SD-induced memory impairments by inhibit...
Source: Brain Research Bulletin - May 6, 2020 Category: Neurology Authors: Wang W, Yang L, Liu T, Ma Y, Huang S, He M, Wang J, Wen A, Ding Y Tags: Brain Res Bull Source Type: research

HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA
In conclusion, IH aggravated apoptosis and autophagy defects in T2DM mice, and increased the protein expression of HMGB1 and TLR4. This was also confirmed in HG +IH-treated hippocampal HT22 cells. HMGB1 siRNA can significantly reduce the protein expression of HMGB1 and TLR4, reverse neuronal apoptosis and enhance autophagy.SignificanceWe believe that HMGB1 is a key factor in the regulation of hippocampal neuronal apoptosis and autophagy defects in T2DM combined with OSA. Targeting HMGB1/TLR4 signaling as a novel approach may delay or prevent the increased apoptosis and decreased autophagy induced by T2DM combined with OSA,...
Source: Life Sciences - November 1, 2019 Category: Biology Source Type: research

Real-life experience on effectiveness and safety of dupilumab in adult patients with moderate-to-severe atopic dermatitis.
Conclusions: Dupilumab significantly improved disease severity, pruritus, sleep loss and quality of life with an acceptable safety profile. PMID: 31647347 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - October 27, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Zinc deficiency up-regulates ET-1 mediated secretion and endothelial cell migration through nuclear HIF-1 translocation.
CONCLUSION: Altogether, the results suggest that zinc deficiency up-regulates ET-1 signaling through HIF-1 activation and stimulates endothelial cell migration suggesting an important role of zinc in the vascular consequences of IH and OSA mediated by the HIF-1-ET- signaling. PMID: 31116583 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - May 21, 2019 Category: Cytology Authors: Morand J, Briancon-Marjollet A, Lemarié E, Gonthier B, Arnaud J, Korichneva I, Godin-Ribuot D Tags: Am J Physiol Cell Physiol Source Type: research

Detailed Dissection of UBE3A-Mediated DDI1 Ubiquitination
Discussion Poly-ubiquitinated proteins targeted for degradation might be recognized directly by proteasomal receptors or by proteasomal shuttling proteins. The first shuttling proteins – Ddi1, Rad23 and Dsk2 – were identified and characterized in Saccharomyces cerevisiae (Lambertson et al., 1999; Kaplun et al., 2005). Proteasomal shuttles contain an N-terminal ubiquitin-like (UBL) domain that interacts with the 26S proteasome (Finley, 2009), and a C-terminal ubiquitin-binding domain domain (UBD) that binds to ubiquitin or poly-ubiquitin chains (Bertolaet et al., 2001). When ubiquitinated, substrates are capt...
Source: Frontiers in Physiology - May 2, 2019 Category: Physiology Source Type: research

Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Targeting progesterone receptors in newborn males and females: from the animal model to a new perspective for the treatment of apnea of prematurity?
We present original data showing that in newborn rats, selective nPR or mPR agonists are more efficient to reduce apnea frequency at postnatal days 12 than at postnatal day 1, and appear more efficient in males than in females. Furthermore, new results obtained by using intra-cisternal injection of specific siRNA targeting mPRα, mPRβ (two mPR with high brain expression) or nPR suggest that mPRβ regulates the stability of the breathing pattern in males, while effects of nPR appears in females. While several important questions remain to be addressed before a safe clinical use could be proposed, these results highlight th...
Source: Respiratory Physiology and Neurobiology - March 16, 2019 Category: Respiratory Medicine Source Type: research

Increased CTGF expression of circulating fibrocytes in asthmatic patients with severe OSA - the role of HIF-1a and HDAC7
Conclusion: Severe OSA related hypoxia increases CTGF expression in circulating fibrocytes via activation of HIF-1α that requires HDAC7 nuclear co-transprotation. HDAC7 may serve a therapeutic target for airway remodeling in asthmatics with severe OSA.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Wang, T.-Y., Lo, Y.-L., Wang, C.-H., Kuo, H.-P. Tags: Airway Cell Biology and Immunopathology Source Type: research

DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA
Publication date: Available online 18 June 2018Source: Brain, Behavior, and ImmunityAuthor(s): Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing FengAbstractType 2 diabetes mellitus (T2DM) complicated with obstructive sleep apnea (OSA) may cause neuronal apoptosis and cognitive deficits, but the underlying mechanisms remain unclear. We aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (HMGB1), after high glucose (HG) and intermittent hypoxia (IH) exposure. Diabetic KK-Ay mice and non-diabetic C57BL/6J...
Source: Brain, Behavior, and Immunity - July 10, 2018 Category: Neurology Source Type: research