Filtered By:
Condition: Sleep Disorders

This page shows you your search results in order of date. This is page number 3.

Order by Relevance | Date

Total 41 results found since Jan 2013.

DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA
Publication date: Available online 18 June 2018 Source:Brain, Behavior, and Immunity Author(s): Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Feng Type 2 diabetes mellitus (T2DM) complicated with obstructive sleep apnea (OSA) may cause neuronal apoptosis and cognitive deficits, but the underlying mechanisms remain unclear. We aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (HMGB1), after high glucose (HG) and intermittent hypoxia (IH) exposure. Diabetic KK-Ay mice and non-diabetic C57BL/6J mice...
Source: Brain, Behavior, and Immunity - June 19, 2018 Category: Neurology Source Type: research

DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA.
Abstract Type 2 diabetes mellitus (T2DM) complicated with obstructive sleep apnea (OSA) may cause neuronal apoptosis and cognitive deficits, but the underlying mechanisms remain unclear. We aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (HMGB1), after high glucose (HG) and intermittent hypoxia (IH) exposure. Diabetic KK-Ay mice and non-diabetic C57BL/6J mice (C57 mice) underwent IH or normoxia (control) exposure for 4 weeks. Cognitive function, microglial activation and hippocampal neuronal apoptos...
Source: Brain, Behavior, and Immunity - June 16, 2018 Category: Neurology Authors: Shi Y, Guo X, Zhang J, Zhou H, Sun B, Feng J Tags: Brain Behav Immun Source Type: research

Bmal1 knockdown suppresses wake and increases immobility without altering orexin A, corticotrophin-releasing hormone, or glutamate decarboxylase.
CONCLUSION: Bmal1 KD led to reduced activity, increased immobility, and dramatic reduction in time spent awake as well as an increase in sleep during the dark phase. Early after injection, there was a slight change in sleep but brain levels of orexin, CRH, and GAD remain unchanged. Control siRNA also affected sleep associated with changes in orexin levels. PMID: 29446232 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - February 14, 2018 Category: Neuroscience Authors: Akladious A, Azzam S, Hu Y, Feng P Tags: CNS Neurosci Ther Source Type: research

Effects of small interfering RNA targeting TLR4 on expressions of adipocytokines in obstructive sleep apnea hyponea syndrome with hypertension in a rat model
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 7, 2017 Category: Cytology Authors: Jing ‐Guo Wu, Nan Xun, Li‐Jin Zeng, Zhen‐Yu Li, Yan‐Bing Liang, Hao Tang, Zhong‐Fu Ma Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Orexin-A aggravates the impairment of hippocampal neurons caused by intermittent hypoxemia by the OXR-PLCβ1-ERK1/2 pathway
Obstructive sleep apnea is a highly prevalent but under-recognized disorder that causes neurocognitive deficits such as spatial memory and learning deficits. These deficits are frequently accompanied by an increase in orexin-A, which has been shown to be involved in learning and memory as well as in neuronal apoptosis in brain areas involved in cognition, such as the hippocampus. The aim of this work was to study the possible harmful effects of orexin-A on intermittent hypoxemia-induced hippocampal neuronal damage and to investigate the potential underlying molecular mechanisms and signaling pathways in vitro. We establish...
Source: NeuroReport - April 3, 2017 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Modulation of primary cilia length by melanin-concentrating hormone receptor 1.
We report here that MCH treatment significantly reduced cilia length in hTERT-RPE1 cells (hRPE1 cells) transfected with MCHR1. Quantitative analyses indicated that MCH-induced cilia shortening progressed in a dose-dependent manner with an EC50 lower than 1nM when cells were treated for 6h. Although the assembly and disassembly of primary cilia are tightly coupled to the cell cycle, cell cycle reentry was not a determinant of MCH-induced cilia shortening. We confirmed that MCH elicited receptor internalization, Ca(2+) mobilization, ERK and Akt phosphorylation, and inhibition of cyclic AMP accumulation in MCHR1-expressing hR...
Source: Cellular Signalling - March 2, 2016 Category: Cytology Authors: Hamamoto A, Yamato S, Katoh Y, Nakayama K, Yoshimura K, Takeda S, Kobayashi Y, Saito Y Tags: Cell Signal Source Type: research

The role of hypoxia and the circadian rhythm in sleep apnoea
Conclusion: Hypoxia in OSA causes an increase of HIF-1α which in turn disrupts the circadian rhythm in vitro. This pathway might be a potential target in tackling sleep apnoea.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Jaspers, T., Morrell, M., Simonds, A., Adcock, I., Durham, A. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a
Publication date: 5 August 2015 Source:Neuron, Volume 87, Issue 3 Author(s): Tsvetan Serchov, Hans-Willi Clement, Martin K. Schwarz, Felice Iasevoli, Dilip K. Tosh, Marco Idzko, Kenneth A. Jacobson, Andrea de Bartolomeis, Claus Normann, Knut Biber, Dietrich van Calker Major depressive disorder is among the most commonly diagnosed disabling mental diseases. Several non-pharmacological treatments of depression upregulate adenosine concentration and/or adenosine A1 receptors (A1R) in the brain. To test whether enhanced A1R signaling mediates antidepressant effects, we generated a transgenic mouse with enhanc...
Source: Neuron - August 6, 2015 Category: Neuroscience Source Type: research

Regulatory effects of AT 1 R-TRAF6-MAPKs signaling on proliferation of intermittent hypoxia-induced human umbilical vein endothelial cells
This study aimed to characterize the role of MyD88/TRAF6 in IH-treated cell function and its associated signaling. Human umbilical vein endothelial cells (HUVECs) were randomly exposed to IH or normoxia for 0, 2, 4 and 6 h. Western blotting was used to detect the expression pattern of target gene proteins [angiotensin 1 receptor (AT1R), p-ERK1/2, p-p38MAPK, MyD88 and TRAF6], and the relationships among these target genes down-regulated by the corresponding inhibitors were studied. Finally, the influence of these target genes on proliferation of HUVECs was also assessed by EdU analysis. Protein levels of AT1R, TRAF6 and p-E...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - July 31, 2015 Category: Research Source Type: research

Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4.
CONCLUSIONS: Hypoxia inducible factor 1-mediated increase in adipose Angptl4 and ensuing lipoprotein lipase inactivation may contribute to atherosclerosis in patients with sleep apnea. PMID: 23328524 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Drager LF, Yao Q, Hernandez KL, Shin MK, Bevans-Fonti S, Gay J, Sussan TE, Jun JC, Myers AC, Olivecrona G, Schwartz AR, Halberg N, Scherer PE, Semenza GL, Powell DR, Polotsky VY Tags: Am J Respir Crit Care Med Source Type: research

Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep
Abstract Dysfunction of the orexin/hypocretin neurotransmitter system causes the sleep disorder narcolepsy, characterized by intrusion of rapid eye movement (REM) sleep‐like events into normal wakefulness. The sites where orexins act to suppress REM sleep are incompletely understood. Previous studies suggested that the lateral pontomesencephalic tegmentum (lPMT) contains an important REM sleep inhibitory area, and proposed that orexins inhibit REM sleep via orexin type 2 receptors (OxR2) in this region. However, this hypothesis has heretofore not been tested. We thus performed bilateral injection of small interfering RNA...
Source: European Journal of Neuroscience - January 3, 2013 Category: Neuroscience Authors: Lichao Chen, James T. McKenna, Yunren Bolortuya, Ritchie E. Brown, Robert W. McCarley Tags: Research Report Source Type: research