Filtered By:
Condition: Cirrhosis

This page shows you your search results in order of date. This is page number 5.

Order by Relevance | Date

Total 82 results found since Jan 2013.

RNA Interference as a Therapeutic Strategy for the Treatment of Liver Diseases.
Abstract RNA interference has emerged as an innovative technology for gene silencing that degrades mRNAs complementary to the antisense strands of double-stranded, short interfering RNAs (siRNAs). Its therapeutic application has important advantages over small-molecule drugs since offers the possibility of targeting virtually all genes and allows selective silencing of one or several genes. So far, a relative small proportion of cellular proteins can bind and respond to chemical drugs. Based on that, RNA interference-mediated gene silencing is widely considered as a crucial breakthrough in molecular biology with a...
Source: Current Pharmaceutical Design - October 23, 2015 Category: Drugs & Pharmacology Authors: Gonzalez-Rodriguez A, Valverde AM Tags: Curr Pharm Des Source Type: research

SUMO1 depletion prevents lipid droplet accumulation and HCV replication
Abstract Infection by hepatitis C virus (HCV) is a major public-health problem. Chronic infection often leads to cirrhosis, steatosis, and hepatocellular carcinoma. The life cycle of HCV depends on the host cell machinery and involves intimate interaction between viral and host proteins. However, the role of host proteins in the life cycle of HCV remains poorly understood. Here, we identify the small ubiquitin-related modifier (SUMO1) as a key host factor required for HCV replication. We performed a series of cell biology and biochemistry experiments using the HCV JFH-1 (Japanese fulminate hepatitis 1) genotype 2a...
Source: Archives of Virology - October 8, 2015 Category: Virology Source Type: research

NICOTINAMIDE N-METHYLTRANSFERASE increases complex I activity IN SH-SY5Y cells via SIRTUIN-3.
Abstract Nicotinamide N-methyltransferase (NNMT, E.C. 2.1.1.1) N-methylates nicotinamide to 1-methylnicotinamide. We have previously shown that NNMT is significantly overexpressed in the brains of patients who have died of Parkinson's disease, and others have shown that NNMT is significantly overexpressed in a variety of diseases ranging from cancer to hepatic cirrhosis. In vitro overexpression has revealed many cytoprotective effects of NNMT, in particular increased complex I activity and ATP synthesis. Although this appears to be mediated by an increase in 1-methylnicotinamide production, the molecular mechanism...
Source: Biochemical and Biophysical Research communications - October 8, 2015 Category: Biochemistry Authors: Liu KY, Mistry RJ, Aguirre CA, Fasouli ES, Thomas MG, Klamt F, Ramsden DB, Parsons RB Tags: Biochem Biophys Res Commun Source Type: research

Specific hepatic delivery of procollagen α1(I) siRNA in lipid‐like nanoparticles resolves liver fibrosis
Conclusion: The data reported in the present study extensively show that LNP‐siCol1a1 specifically reduce total hepatic collagen content without detectable side effects, potentially qualifying as a therapy for fibrotic liver diseases. This article is protected by copyright. All rights reserved.
Source: Hepatology - June 10, 2015 Category: Internal Medicine Authors: Carolina Jiménez Calvente, Alfica Sehgal, Yury Popov, Yong Ook Kim, Victor Zevallos, Ugur Sahin, Mustafa Diken, Detlef Schuppan Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research

Lipopolysaccharide (LPS)-Induced Biliary Epithelial Cell NRas Activation Requires Epidermal Growth Factor Receptor (EGFR)
by Christy E. Trussoni, James H. Tabibian, Patrick L. Splinter, Steven P. O’Hara Cholangiocytes (biliary epithelial cells) actively participate in microbe-induced proinflammatory responses in the liver and contribute to inflammatory and infectious cholangiopathies. We previously demonstrated that cholangiocyte TLR-dependent NRas activation contributes to proinflammatory/ proliferative responses. We test the hypothesis that LPS-induced activation of NRas requires the EGFR. SV40-transformed human cholangiocytes (H69 cells), or low passage normal human cholangiocytes (NHC), were treated with LPS in the presence or absence ...
Source: PLoS One - April 27, 2015 Category: Biomedical Science Authors: Christy E. Trussoni et al. Source Type: research

High CHMP4B expression is associated with accelerated cell proliferation and resistance to doxorubicin in hepatocellular carcinoma
In this study, we explored the prognostic significance of CHMP4B in human hepatocellular carcinoma (HCC) and its impact on the physiology of HCC cells. Western blot and immunohistochemistrical analyses showed that CHMP4B was significantly upregulated in HCC tissues, compared with adjacent non-tumorous tissues. Meanwhile, clinicopathological analysis revealed that high CHMP4B expression was correlated with multiple clinicopathological variables, including AFP, cirrhosis, AJCC stage, Ki-67 expression, and poor prognosis. More importantly, univariate and multivariate survival analyses demonstrated that CHMP4B served as an ind...
Source: Tumor Biology - February 10, 2015 Category: Cancer & Oncology Source Type: research

Transarterial chemoembolization aggravated peritumoral fibrosis via HIF‐1α dependent pathway in hepatocellular carcinoma
ConclusionsOur data demonstrate that TACE‐induced hepatic hypoxia aggravates the fibrosis progression in peritumoral liver tissue, thus leads to the deterioration of liver function. Intervention of HIF‐1α might be a valuable strategy to optimize the efficacy and reduce the complication of TACE.
Source: Journal of Gastroenterology and Hepatology - December 31, 2014 Category: Gastroenterology Authors: Kai Qu, Zhaoyong Yan, Yousheng Wu, Yibing Chen, Ping Qu, Xinsen Xu, Peng Yuan, Xiaojun Huang, Jinliang Xing, Hongxin Zhang, Chang Liu, Jing Zhang Tags: Experimental Hepatology Source Type: research

Emerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infection.
Abstract Infection with hepatitis C virus (HCV), a major viral cause of chronic liver disease, frequently progresses to steatosis and cirrhosis, which can lead to hepatocellular carcinoma. HCV infection strongly induces host responses, such as the activation of the unfolded protein response, autophagy and the innate immune response. Upon HCV infection, the host induces the interferon (IFN)-mediated frontline defense to limit virus replication. Conversely, HCV employs diverse strategies to escape host innate immune surveillance. Type I IFN elicits its antiviral actions by inducing a wide array of IFN-stimulated gen...
Source: Cellular and Molecular Immunology - December 29, 2014 Category: Molecular Biology Authors: Wong M, Chen SS Tags: Cell Mol Immunol Source Type: research

Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness
Publication date: 2014 Source:Redox Biology, Volume 3 Author(s): Christopher B. Forsyth , Robin M. Voigt , Ali. Keshavarzian Chronic alcohol use can result in many pathological effects including alcoholic liver disease (ALD). While alcohol is necessary for the development of ALD, only 20–30% of alcoholics develop alcoholic steatohepatitis (ASH) with progressive liver disease leading to cirrhosis and liver failure (ALD). This suggests that while chronic alcohol consumption is necessary it is not sufficient to induce clinically relevant liver damage in the absence of a secondary risk factor. Studies in rodent models and ...
Source: Redox Biology - December 14, 2014 Category: Biology Source Type: research

Bone Marrow Stromal Cells Inhibit the Activation of Liver Cirrhotic Fat-Storing Cells via Adrenomedullin Secretion
Conclusions Our data suggested that BMSCs inhibited CFSC activation in vitro via the AM-Ang II-p47-phox signaling pathway, and since CFSC activation is an essential part of hepatic fibrosis process, this inhibition by BMSCs implies us new insights into the potential treatment of hepatic fibrosis via BMSCs.
Source: Digestive Diseases and Sciences - December 2, 2014 Category: Gastroenterology Source Type: research

Abstract 3171: Overexpression of a cancer stem cell marker doublecortin-like kinase (DCLK1) leads to activation of inflammatory cascade during development of virus-induced hepatocellular carcinoma
Conclusions: DCLK1 overexpression appears to be intimately related to the activation of pro-inflammatory and MAPK signaling pathways during the development of virus-induced pre-neoplastic conditions and initiation of tumors in liver. Thus, targeting DCLK1 at early stage of liver diseases may prevent virus-induced cirrhosis and HCC. Citation Format: Naushad Ali, Parthasarathy Chandrakesan, Mark Huycke, Sanam Husain, Allison F. Gillaspy, Randal May, William L. Berry, Sripathi Sureban, Dongfeng Qu, Nathaniel Weygant, Michael S. Bronze, Danny N. Dhanasekaran, Courtney W. Houchen. Overexpression of a cancer stem cell marker dou...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Ali, N., Chandrakesan, P., Huycke, M., Husain, S., Gillaspy, A. F., May, R., Berry, W. L., Sureban, S., Qu, D., Weygant, N., Bronze, M. S., Dhanasekaran, D. N., Houchen, C. W. Tags: Carcinogenesis Source Type: research

Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation.
CONCLUSION: OPN is a key mediator of the alcohol-induced effects on hepatic stellate cell functions and liver fibrogenesis. PMID: 25278703 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 28, 2014 Category: Gastroenterology Authors: Seth D, Duly A, Kuo PC, McCaughan GW, Haber PS Tags: World J Gastroenterol Source Type: research

Tumor suppressor micro RNA miR-145 and onco micro RNAs miR-21 and miR-222 expressions are differentially modulated by Hepatitis B virus X protein in malignant hepatocytes
Conclusion: Thus, HBx protein differentially modulated the expression of miRNAs. The study throws light into possible way by which HBx protein acts through microRNA and thereby regulate host functioning. It might suggest new therapeutic strategies against hepatic cancer.
Source: BMC Cancer - September 26, 2014 Category: Cancer & Oncology Authors: Manikankana BandopadhyayArup BanerjeeNeelakshi SarkarRajesh PanigrahiSibnarayan DattaAnanya PalShivram SinghAvik BiswasShekhar ChakrabartiRunu Chakravarty Source Type: research

Ursolic acid via LKB1‐AMPK signaling suppresses oxidative stress and improves liver functions in mice
ConclusionUA via LKB1‐AMPK signaling offers protective effects on BDL‐induced liver injury in mice, which may be related to inhibition of oxidative stress.
Source: Journal of Gastroenterology and Hepatology - August 28, 2014 Category: Gastroenterology Authors: Yang Yongbin, Zhao Zhanxue, Liu Yuanjun, Kang Xianjiang, Zhang Haisong, Meng Ming Tags: Experimental Hepatology Source Type: research

The role of von Willebrand factor as a biomarker of tumor development in hepatitis B virus-associated human hepatocellular carcinoma: a quantitative proteomic based study.
We report comparative plasma proteome profiles of HBV-associated HCC and nonmalignant chronic liver diseases, including chronic hepatitis B and cirrhosis. The quantification of these datasets showed altered abundance of 21 proteins in HBV-related HCC and provides a reference point for future applied and basic research. In addition, we have demonstrated that the candidate protein vWF is involved in the pathogenesis of HBV infection and replication, and also associated with clinicopathologic staging of HCC patients with HBV infection. Overall these findings provide information on the mechanism of HCC development, which may a...
Source: Journal of Proteomics - April 23, 2014 Category: Biochemistry Authors: Liu Y, Wang X, Li S, Hu H, Zhang D, Hu P, Yang Y, Ren H Tags: J Proteomics Source Type: research