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Condition: Ganglions

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Total 160 results found since Jan 2013.

Translesion Synthesis DNA Polymerase Kappa Is Indispensable for DNA Repair Synthesis in Cisplatin Exposed Dorsal Root Ganglion Neurons
AbstractIn the peripheral nervous system (PNS) in the absence of tight blood barrier, neurons are at increased risk of DNA damage, yet the question of how effectively PNS neurons manage DNA damage remains largely unanswered. Genotoxins in systemic circulation include chemotherapeutic drugs that reach peripheral neurons and damage their DNA. Because neurotoxicity of platinum-based class of chemotherapeutic drugs has been implicated in PNS neuropathies, we utilized an in vitro model of Dorsal Root Ganglia (DRGs) to investigate how peripheral neurons respond to cisplatin that forms intra- and interstrand crosslinks with their...
Source: Molecular Neurobiology - April 8, 2017 Category: Neurology Source Type: research

Molecular determinants of cytochrome C oxidase IV mRNA axonal trafficking
Publication date: Available online 1 February 2017 Source:Molecular and Cellular Neuroscience Author(s): Amar N. Kar, Jose Norberto S. Vargas, Cai-Yun Chen, Jeffrey A Kowalak, Anthony E. Gioio, Barry B. Kaplan In previous studies, we identified a putative 38-nucleotide stem-loop structure (zipcode) in the 3′ untranslated region of the cytochrome c oxidase subunit IV (COXIV) mRNA that was necessary and sufficient for the axonal localization of the message in primary superior cervical ganglion (SCG) neurons. However, little is known about the proteins that interact with the COXIV-zipcode and regulate the axonal traffickin...
Source: Molecular and Cellular Neuroscience - February 1, 2017 Category: Neuroscience Source Type: research

Neuronal Fc-epsilon receptor I contributes to antigen-evoked pruritus in a murine model of ocular allergy.
This study may suggest a novel mechanism for the development of pathological itch in allergic diseases. PMID: 27865948 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - November 15, 2016 Category: Neurology Authors: Liu F, Xu L, Chen N, Zhou M, Li C, Yang Q, Xie Y, Huang Y, Ma C Tags: Brain Behav Immun Source Type: research

Neuronal Fc-epsilon receptor I contributes to antigen-evoked pruritus in a murine model of ocular allergy
This study may suggest a novel mechanism for the development of pathological itch in allergic diseases.
Source: Brain, Behavior, and Immunity - November 15, 2016 Category: Neurology Source Type: research

Small-molecule GSK-3 inhibitor rescued apoptosis and neurodegeneration in anesthetics-injured dorsal root ganglion neurons
Conclusions GSK-3 inhibitor SB216763, through PKC, is effective in protecting anesthetics-induced neurotoxicity in DRG.
Source: Biomedicine and Pharmacotherapy - September 23, 2016 Category: Drugs & Pharmacology Source Type: research

Small-molecule GSK-3 inhibitor rescued apoptosis and neurodegeneration in anesthetics-injured dorsal root ganglion neurons.
CONCLUSIONS: GSK-3 inhibitor SB216763, through PKC, is effective in protecting anesthetics-induced neurotoxicity in DRG. PMID: 27668540 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 22, 2016 Category: Drugs & Pharmacology Authors: Yu T, Lin W Tags: Biomed Pharmacother Source Type: research

Contribution of the Suppressor of Variegation 3-9 Homolog 1 in Dorsal Root Ganglia and Spinal Cord Dorsal Horn to Nerve Injury –induced Nociceptive Hypersensitivity
Conclusions The findings of this study suggest that SUV39H1 contributes to nerve injury –induced allodynia and hyperalgesia through gating MOR expression in the injured DRG. SUV39H1 may be a potential target for the therapeutic treatment of nerve injury–induced nociceptive hypersensitivity.
Source: Anesthesiology - September 20, 2016 Category: Anesthesiology Source Type: research

Gγ7 proteins contribute to coupling of nociceptin/orphanin FQ peptide (NOP) opioid receptors and voltage-gated Ca2+ channels in rat stellate ganglion neurons
Publication date: 3 August 2016 Source:Neuroscience Letters, Volume 627 Author(s): Saifeldin Mahmoud, Mohamed Farrag, Victor Ruiz-Velasco The nociceptin/orphanin FQ peptide (NOP) opioid receptors regulate neurotransmitter release via inhibition of voltage-gated Ca2+ channels (CaV2.2) in sympathetic and sensory neurons. Stimulation of NOP receptors by its endogenous agonist, nociception (Noc), leads to membrane-delimited, voltage-dependent (VD) block of CaV2.2 channel currents mediated by Gβγ protein subunits. Previously we reported that the pertussis toxin-sensitive Gαi1 and Gβ2/β4 isoforms mediate the functional...
Source: Neuroscience Letters - June 6, 2016 Category: Neuroscience Source Type: research

Inhibition of long non-coding RNA IGF2AS has profound effect on inducing neuronal growth and protecting local-anesthetic induced neurotoxicity in dorsal root ganglion neurons
Conclusions Inhibiting endogenous IGF2AS may promote neuronal growth and protect local-anesthetic induced neurotoxicity in DRG neurons, possibly through complimentary IGF2 upregulation and autocrine activation neurotrophin genes.
Source: Biomedicine and Pharmacotherapy - May 17, 2016 Category: Drugs & Pharmacology Source Type: research

Amitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons
Abstract: Tricyclic antidepressant amitriptyline (AM) has been shown to exert neurotrophic activity on neurons. We thus explored whether AM may aid the neuronal development and protect anesthesia-induced neuro-injury in young spinal cord dorsal root ganglion (DRG) neurons. The DRG explants were prepared from 1-day-old rats. The effect of AM on aiding DRG neural development was examined by immunohistochemistry at dose-dependent manner. AM-induced changes in gene and protein expressions, and also phosphorylation states of tyrosine kinases receptor A (TrkA) and B (TrkB) in DRG, were examined by quantitative real-time polymer...
Source: Medicine - May 1, 2016 Category: Internal Medicine Tags: Research Article: Meta-Analysisof Observ Studiesin Epidemiology Source Type: research

Long noncoding RNA BDNF-AS protects local anesthetic induced neurotoxicity in dorsal root ganglion neurons.
CONCLUSIONS: BDNF-AS downregulation rescued local anesthetic-induce neurotoxicity in DRG neurons, probably through the activation of neurotrophin TrkB signaling pathway. PMID: 27133058 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2016 Category: Drugs & Pharmacology Authors: Zhang Y, Yan L, Cao Y, Kong G, Lin C Tags: Biomed Pharmacother Source Type: research

Neuroprotection by GH against excitotoxic-induced cell death in retinal ganglion cells.
Abstract Retinal growth hormone (GH) has been shown to promote cell survival in retinal ganglion cells (RGCs) during developmental waves of apoptosis during chicken embryonic development. The possibility that it might also against excitotoxicity-induced cell death was therefore examined in the present study, which utilized quail-derived QNR/D cells as an in vitro RGC model. QNR/D cell death was induced by glutamate in the presence of BSO (buthionine sulfoxamide) (an enhancer of oxidative stress), but this was significantly reduced (P<0.01) in the presence of exogenous recombinant chicken GH (rcGH). Similarly, Q...
Source: General and Comparative Endocrinology - April 25, 2016 Category: Endocrinology Authors: Martínez-Moreno CG, Ávila-Mendoza J, Wu Y, Arellanes-Licea ED, Louie M, Luna M, Arámburo C, Harvey S Tags: Gen Comp Endocrinol Source Type: research

Opioid Receptor Expression in Neuropathic Pain Neurobiology
In this study, we determined the role of G9a in diminished MOR expression and opioid analgesic effects in animal models of neuropathic pain. We found that nerve injury in rats induced a long-lasting reduction in the expression level of MORs in the DRG but not in the spinal cord. Nerve injury consistently increased the enrichment of the G9a product histone 3 at lysine 9 dimethylation in the promoter of Oprm1 in the DRG. G9a inhibition or siRNA knockdown fully reversed MOR expression in the injured DRG and potentiated the morphine effect on pain hypersensitivity induced by nerve injury. In mice lacking Ehmt2 in DRG neurons, ...
Source: Journal of Biological Chemistry - April 14, 2016 Category: Chemistry Authors: Zhang, Y., Chen, S.-R., Laumet, G., Chen, H., Pan, H.-L. Tags: Molecular Bases of Disease Source Type: research

Long noncoding RNA BDNF-AS protects local anesthetic induced neurotoxicity in dorsal root ganglion neurons
Conclusions BDNF-AS downregulation rescued local anesthetic-induce neurotoxicity in DRG neurons, probably through the activation of neurotrophin TrkB signaling pathway.
Source: Biomedicine and Pharmacotherapy - March 28, 2016 Category: Drugs & Pharmacology Source Type: research

Cdon, a cell surface protein, mediates oligodendrocyte differentiation and myelination
The objective of our study was to assess whether Cdon, a cell surface protein that was shown to participate in muscle and neuron cell development, is involved in oligodendrocyte (OLG) differentiation and myelination. Here, we demonstrate that endogenous Cdon protein is expressed in OLPs, increasing in the early differentiation stages and decreasing in mature OLGs. Immunocytochemistry of endogenous Cdon showed localization on both OLG cell membranes and cellular processes exhibiting puncta‐ or varicosity‐like structures. Cdon knockdown with siRNA decreased protein levels by 62% as well as two myelin‐specific proteins,...
Source: Glia - March 15, 2016 Category: Neurology Authors: Li‐Chun Wang, Guillermina Almazan Tags: Research Article Source Type: research