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Condition: Ganglions
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Total 160 results found since Jan 2013.
Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice
ConclusionOur study elucidates a novel signaling cascade wherein adiponectin stimulates TG Cav3.2 channels via adipoR1 coupled to a novel CK2 α-dependent PKCβ1. This process induces neuronal hyperexcitability and pain hypersensitivity. Insight into adipoR-Cav3.2 signaling in sensory neurons provides attractive targets for pain treatment.
Source: The Journal of Headache and Pain - August 25, 2023 Category: Neurology Source Type: research
Metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion
This study aims to evaluate the protective effect of metformin against retinal I/R injury and its underlying mechanism. I/R induced reduction in retina thickness and cell number in ganglion cell layer, and metformin alleviated I/R-induced retinal injury. Both retinal I/R and simulated ischemia/reperfusion (SIR) in R28 cells down-regulated expression of mitochondrial fusion protein Mfn2 and OPA1, which led to mitochondrial fission. Metformin also alleviated damage in R28 cells, and reversed the alteration in Mfn2 and OPA1, mitochondrial fission and mitochondrial membrane potential (MMP) disruption-induced by I/R or SIR as w...
Source: Free Radical Biology and Medicine - May 30, 2023 Category: Biology Authors: Kun Zhang Tao Wang Gui-Feng Sun Jin-Xing Xiao Li-Ping Jiang Fang-Fang Tou Xin-Hui Qu Xiao-Jian Han Source Type: research
Reduction of SIRT1-Mediated Epigenetic Upregulation of Nav1.7 Contributes to Oxaliplatin-Induced Neuropathic Pain
CONCLUSIONS: These findings suggest that reduction of SIRT1-mediated epigenetic upregulation of Nav1.7 in the DRG contributes to the development of oxaliplatin-induced neuropathic pain in rats. The intrathecal drug delivery treatment of activating SIRT1 might be a novel therapeutic option for oxaliplatin-induced neuropathic pain.PMID:37192244
Source: Pain Physician - May 16, 2023 Category: Anesthesiology Authors: Ling-Jun Xu Jing Wang Gui-Dan Li Kai-Feng Shen Xing-Hui He Wei Wu Cui-Cui Liu Source Type: research
siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative Induced Apoptosis in Retinal Ganglion Cells
CONCLUSION: The results suggested that siRhoA may exert potentially effective neuroprotection for RGCs by reducing injury.PMID:37171014 | DOI:10.2174/1566524023666230511095628
Source: Molecular Medicine - May 12, 2023 Category: Molecular Biology Authors: Qian Liu Changgeng Liu Bo Lei Source Type: research
Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors
ConclusionThese results suggest that tyramine induces Kv1.4-mediatedIA suppression through stimulation of TAAR1 coupled to the Gβγ-dependent PKCθ signaling cascade, thereby enhancing TG neuronal excitability and mechanical pain sensitivity. Insight into TAAR1 signaling in sensory neurons provides attractive targets for the treatment of headache disorders such as migraine.
Source: The Journal of Headache and Pain - May 8, 2023 Category: Neurology Source Type: research
Targeting CXCL1 chemokine signaling for treating cisplatin ototoxicity
In this study, we investigated the role of CXCL1, a cytokine which increased in the serum and cochlea by 24 h following cisplatin administration. Adult male Wistar rats treated with cisplatin demonstrated significant hearing loss, assessed by auditory brainstem responses (ABRs), hair cell loss and loss of ribbon synapse. Immunohistochemical studies evaluated the levels of CXCL1 along with increased presence of CD68 and CD45-positive immune cells in cochlea. Increases in CXCL1 was time-dependent in the spiral ganglion neurons and organ of Corti and was associated with progressive increases in CD45, CD68 and IBA1-positive i...
Source: Frontiers in Immunology - March 31, 2023 Category: Allergy & Immunology Source Type: research
Saikosaponin d (SSD) alleviates diabetic peripheral neuropathy by regulating the AQP1/RhoA/ROCK signaling in streptozotocin-induced diabetic rats
ConclusionSSD alleviates STZ/HFD-induced DPN in rats by inhibiting the AQP1/RhoA/ROCK signaling pathway.
Source: Acta Diabetologica - March 15, 2023 Category: Endocrinology Source Type: research
Phosphate NIMA-Related Kinase 2-Dependent Epigenetic Pathways in Dorsal Root Ganglion Neurons Mediates Paclitaxel-Induced Neuropathic Pain
CONCLUSIONS: pRSK2/JMJD3/H3K27me3/TRPV1 signaling in the DRG neurons plays as a key regulator for PTX therapeutic approaches.PMID:36753440 | DOI:10.1213/ANE.0000000000006397
Source: Anesthesia and Analgesia - February 8, 2023 Category: Anesthesiology Authors: Ming-Chun Hsieh Cheng-Yuan Lai Wen-Long Cho Li-Ting Lin Chou-Ming Yeh Po-Sheng Yang Jen-Kun Cheng Hsueh-Hsiao Wang Kuan-Hung Lin Siao-Tong Nie Tzer-Bin Lin Hsien-Yu Peng Source Type: research
