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Condition: Ganglions

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Total 160 results found since Jan 2013.

BDNF Participates in Chronic Constriction Injury-Induced Neuropathic Pain via Transcriptionally Activating P2X 7 in Primary Sensory Neurons
In this study, we demonstrated that the expression level of brain-derived neurotrophic factor (BDNF) was remarkably and time-dependently increased in dorsal root ganglion (DRG) neurons. DRG microinjection of BDNF siRNA in DRG ameliorated chronic constriction injury (CCI) induced mechanical, thermal, and cold nociceptive hypersensitivities. Overexpressing BDNF through microinjection of the AAV5-BDNF in DRG caused enhanced responses to basal mechanical, thermal, and cold stimuli in mice exposed to CCI. Mechanically, the P2X7 promoter activity was enhanced by CCI-induced increase of DRG BDNF protein and was involved in the CC...
Source: Molecular Neurobiology - May 7, 2021 Category: Neurology Source Type: research

Erythropoietin inhibits apoptosis of retinal ganglion cells induced by high glucose through JNK signaling pathway
J Biol Regul Homeost Agents. 2021 Mar 23;35(2). doi: 10.23812/20-646-A. Online ahead of print.ABSTRACTThe aim of this study was to investigate the effect of erythropoietin (EPO) on the apoptosis of retinal ganglion cells (RGCs) induced by high glucose and its mechanism. Rat primary RGCs were extracted to establish high glucose-induced apoptosis models using a 30 mM high-glucose medium. Then flow cytometry, cell counting kit-8 (CCK-8) assay and Western blotting assay were performed to detect the effects of high-, medium- and low-dose EPO on the apoptosis of RGCs induced by high glucose. Next, the molecular mechanism by whic...
Source: Journal of Biological Regulators and Homeostatic Agents - March 23, 2021 Category: Biomedical Science Authors: Y X Qi X J Su L L Wei J Zhang Source Type: research

LncRNA embryonic stem cells expressed 1 (Lncenc1) is identified as a novel regulator in neuropathic pain by interacting with EZH2 and downregulating the expression of BAI1 in mouse microglia.
In conclusion, Lncenc1 contributes to neuropathic pain by interacting with EZH2 and downregulating the BAI1 gene in mouse microglia. PMID: 33340495 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - December 16, 2020 Category: Cytology Authors: Zhang Z, Sun X, Zhao G, Ma Y, Zeng G Tags: Exp Cell Res Source Type: research

ASAP Enhanced Delivery of siRNA to Retinal Ganglion Cells by Intravitreal Lipid Nanoparticles of Positive Charge
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.0c00992
Source: Molecular Pharmaceutics - December 9, 2020 Category: Drugs & Pharmacology Authors: Xiaonan Huang and Ying Chau Source Type: research

CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons
AbstractChemotherapy-induced peripheral neuropathic pain (CIPNP) often occurs in cancer patients treated with antineoplastic drugs. Therapeutic management of CIPNP is very limited, at least in part due to the largely unknown mechanisms that underlie CIPNP genesis. Here, we showed that systemic administration of the chemotherapeutic drug paclitaxel significantly and time-dependently increased the levels of cyclic AMP response element-binding protein (CREB) in dorsal root ganglion (DRG) neurons. Blocking this increase through DRG microinjection ofCreb siRNA attenuated paclitaxel-induced mechanical, heat, and cold nociceptive...
Source: Neurotherapeutics - October 13, 2020 Category: Neurology Source Type: research

The small molecule inhibitor PR-619 protects retinal ganglion cells against glutamate excitotoxicity
This study was designed to investigate the role of PR-619 in regulating mitophagy of RGCs under glutamate excitotoxicity. Primary cultured RGCs were incubated with PR-619 or vehicle control in the excitotoxicity model of 100 µM glutamate treatment. Mitochondrial membrane potential was assessed by JC-1 assay. Cytotoxicity of RGCs was measured by LDH activity. Proteins levels of parkin, optineurin, LAMP1, Bax, Bcl-2 and the LC3-II/I ratio were analyzed by western blot. The distribution and morphology of mitochondria in RGCs was stained by MitoTracker and antibody against mitochondria membrane protein, and examined by confoc...
Source: NeuroReport - October 6, 2020 Category: Neurology Tags: Degeneration and Repair Source Type: research

Chronic hyperglycemia impairs mitochondrial unfolded protein response and precipitates proteotoxicity in experimental diabetic neuropathy: focus on LonP1 mediated mitochondrial regulation.
CONCLUSION: These results would signify the importance of modulating mitochondrial proteases for the therapeutic management of DN. PMID: 32720218 [PubMed - as supplied by publisher]
Source: Pharmacological Reports - July 26, 2020 Category: Drugs & Pharmacology Authors: Kalvala AK, Yerra VG, Sherkhane B, Gundu C, Arruri V, Kumar R, Kumar A Tags: Pharmacol Rep Source Type: research

MTIM affects retinal ganglion cells through PI3K/AKT signaling pathway.
CONCLUSIONS: Up-regulation of MT1M can inhibit RGC cell apoptosis and inflammation, and promote RGC cell proliferation through the PI3K/AKT signaling pathway. PMID: 32495853 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 5, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

AIF knockdown induce apoptosis and mitochondrial dysfunction in cochlear spiral ganglion neurons in  vitro.
AIF knockdown induce apoptosis and mitochondrial dysfunction in cochlear spiral ganglion neurons in vitro. Mol Med Rep. 2020 Jan 31;: Authors: Zong L, Zhao J, Wu W, Wang J, Huang D, Liu M Abstract The underlying mechanism involved in auditory neuropathy spectrum disorder (ANSD) remains largely unclear. It has been previously reported that mutations in the apoptosis‑inducing factor (AIF) gene are associated with auditory neuropathy and delayed peripheral neuropathy, which can eventually cause ANSD. In the present study, the regulatory effects of AIF knockdown on the cellular functions of spiral gangl...
Source: Molecular Medicine Reports - April 24, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
CONCLUSIONS: MiR-375 inhibitors are able to reduce blood glucose, retinal permeability, and optic ganglion apoptosis in rats with DR, and the mechanism of action may be related to the regulation on the Ndrg2/IL-6/STAT3 signaling pathway. PMID: 32196570 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - March 21, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Alpha-lipoic acid downregulates TRPV1 receptor via NF- κB and attenuates neuropathic pain in rats with diabetes.
CONCLUSION: Our findings demonstrated that ALA may alleviate neuropathic pain in diabetes by regulating TRPV1 expression via affecting NF-κB. PMID: 32175676 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - March 15, 2020 Category: Neuroscience Authors: Zhang BY, Zhang YL, Sun Q, Zhang PA, Wang XX, Xu GY, Hu J, Zhang HH Tags: CNS Neurosci Ther Source Type: research

A method for gene knockdown in the retina using a lipid-based carrier.
Conclusions: This work supports the use of Invivofectamine 3.0 as a transfection agent for effective delivery of nucleic acids to the retina for gene function studies and as potential therapeutics. PMID: 32165826 [PubMed - in process]
Source: Molecular Vision - March 15, 2020 Category: Molecular Biology Tags: Mol Vis Source Type: research

RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells.
Abstract Receptor-interacting protein 3 (RIP3) plays an important role in the necroptosis signaling pathway. Our previous studies have shown that the RIP3/mixed lineage kinase domain-like protein (MLKL)-mediated necroptosis occurs in retinal ganglion cell line 5 (RGC-5) following oxygen-glucose deprivation (OGD). However, upstream regulatory pathways of RIP3 are yet to be uncovered. The purpose of the present study was to investigate the role of p90 ribosomal protein S6 kinase 3 (RSK3) in the phosphorylation of RIP3 in RGC-5 cell necroptosis following OGD. Our results showed that expression of RSK3, RIP3, and MLKL...
Source: Journal of Anatomy - March 11, 2020 Category: Anatomy Authors: Wang M, Wan H, Wang S, Liao L, Huang Y, Guo L, Liu F, Shang L, Huang J, Ji D, Xia X, Jiang B, Chen D, Xiong K Tags: J Anat Source Type: research