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Condition: Ganglions
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Total 160 results found since Jan 2013.
Liposomal siRNA Formulations for the Treatment of Herpes Simplex Virus-1: In Vitro Characterization of Physicochemical Properties and Activity, and In Vivo Biodistribution and Toxicity Studies
We examined the role of various parameters, including formulation technique, lipids composition, and ratio. An optimal liposomal siHSV formulation (LipDOPE-siHSV) was characterized with desirable physiochemical properties, in terms of nano-size, low polydispersity index (PDI), neutral surface charge, high siHSV loading, spherical shape, high stability in physiologic conditions in vitro, and long-term shelf-life stability (>1 year, 4 °C). The liposomes exhibited profound internalization by human keratinocytes, no cytotoxicity in cell cultures, no detrimental effect on mice liver enzymes, and a gradual endo-lysosomal...
Source: Herpes - March 26, 2022 Category: Infectious Diseases Authors: Doaa Jbara-Agbaria Saskia Blondzik Anke Burger-Kentischer Majd Agbaria Mirjam M Nordling-David Anna Giterman Gil Aizik Steffen Rupp Gershon Golomb Source Type: research
Nectin-1 and Non-muscle Myosin Heavy Chain-IIB: Major Mediators of Herpes Simplex Virus-1 Entry Into Corneal Nerves
This study observed that receptors nectin-1, HVEM, 3-OS-HS, NMHC-IIA, and NMHC-IIB, not MAG, were expressed in healthy corneal nerves. Further, we cultured TG neurons extracted from mice in vitro to screen for functional gD/gB receptors. Both in vitro siRNA knockdown and in vivo antibody blocking of either nectin-1 or NMHC-IIB reduced the entry and the replication of HSV-1 as shown by qPCR analysis and immunofluorescence measure, respectively. Also, we observed that the re-localization and the upregulation expression of NMHC-IIB after HSV-1 exposure were inhibited when gD receptor nectin-1 was knocked down. These data sugg...
Source: Herpes - March 17, 2022 Category: Infectious Diseases Authors: Chenchen Wang Qi Liang Dong Sun Yun He Jiaxuan Jiang Rongjie Guo Tejsu Malla Pedram Hamrah Xun Liu Zhenping Huang Kai Hu Source Type: research
Identification, tissue specific expression analysis and functional characterization of arrestin gene (ARRDC) in the earthworm Eudrilus eugeniae: a molecular hypothesis behind worm photoreception
CONCLUSIONS: The neuronal and dermal expression patterns of ARRDC gene and its functional characterization hypothesized the role of the gene in assisting the photosensory cells to regulate the process of photoreception and phototransduction in the worm.PMID:35211863 | DOI:10.1007/s11033-022-07256-w
Source: Mol Biol Cell - February 25, 2022 Category: Molecular Biology Authors: Sayan Paul Sudalai Mani Dinesh Kumar Sandhya Soman Syamala Subburathinam Balakrishnan Vijithkumar Vijayan Vaithilingaraja Arumugaswami Sivasubramaniam Sudhakar Source Type: research
Novel Nanotechnological Approaches for Targeting Dorsal Root Ganglion (DRG) in Mitigating Diabetic Neuropathic Pain (DNP)
Diabetic neuropathy is the most entrenched complication of diabetes. Usually, it affects the distal foot and toes, which then gradually approaches the lower part of the legs. Diabetic foot ulcer (DFU) could be one of the worst complications of diabetes mellitus. Long-term diabetes leads to hyperglycemia, which is the utmost contributor to neuropathic pain. Hyperglycemia causing an upregulation of voltage-gated sodium channels in the dorsal root ganglion (DRG) was often observed in models of neuropathic pain. DRG opening frequency increases intracellular sodium ion levels, which further causes increased calcium channel open...
Source: Frontiers in Endocrinology - February 8, 2022 Category: Endocrinology Source Type: research
Bupivacaine Induces ROS-Dependent Autophagic Damage in DRG Neurons via TUG1/mTOR in a High-Glucose Environment
Neurotox Res. 2022 Jan 18. doi: 10.1007/s12640-021-00461-8. Online ahead of print.ABSTRACTBupivacaine (BP) is a commonly clinically used local anesthetic (LA). Current studies suggest that neurological complications are increased in diabetic patients after LA application, but the molecular mechanism is poorly understood. LA-induced autophagy and neuronal injury have been reported. We hypothesized that a high-glucose environment aggravates BP-induced autophagic damage. Mouse dorsal root ganglion (DRG) neurons were treated with BP in a high-glucose environment, and the results showed that reactive oxygen species (ROS) levels...
Source: Cell Research - January 19, 2022 Category: Cytology Authors: Luying Lai Yongwei Wang Shenghui Peng Wenjing Guo Guanshan Wei Le Li Zhengyuan Xia Fengxian Li Shiyuan Xu Source Type: research
Sympathectomy decreases pain behaviors and nerve regeneration by downregulating monocyte chemokine CCL2 in dorsal root ganglia in the rat tibial nerve crush model
In this study, we examined the effect of a localized “microsympathectomy,” ie, cutting the gray rami containing sympathetic postganglionic axons where they enter the L4 and L5 spinal nerves, which is more analogous to clinically used sympathetic blockade compared with chemical or surgical sympathectomy. We also examined manipulations of CCL2 (monocyte chemoattractant protein 1), a key player in both regeneration and pain. We used rat tibial nerve crush as a neuropathic pain model in which peripheral nerve regeneration can occur successfully. CCL2 in the sensory ganglia was increased by tibial nerve crush and reduced by...
Source: Pain - December 27, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research
Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells
AbstractLipidoid nanoparticles (LNPs) are the delivery platform in Onpattro, the first FDA-approved siRNA drug. LNPs are also the carriers in the Pfizer-BioNTech and Moderna COVID-19 mRNA vaccines. While these applications have demonstrated that LNPs effectively deliver nucleic acids to hepatic and muscle cells, it is unclear if LNPs could be used for delivery of siRNA to neural cells, which are notoriously challenging delivery targets. Therefore, the purpose of this study was to determine if LNPs could efficiently deliver siRNA to neurons. Because of their potential delivery utility in either applications for the centra...
Source: The AAPS Journal - December 6, 2021 Category: Drugs & Pharmacology Source Type: research
The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund ’s adjuvant-induced chronic inflammatory pain
ConclusionsThe findings of this study suggest that α7 nAChR may be potentially utilized as a therapeutic target for therapeutics of chronic inflammatory pain.
Source: Inflammopharmacology - September 12, 2021 Category: Drugs & Pharmacology Source Type: research
Identification of lncRNA and mRNA expression profiles in dorsal root ganglion in rats with cancer-induced bone pain
CONCLUSION: LncRNA played important roles in regulation of CIBP or mRNA expression in peripheral neuropathy in CIBP. These alterd mRNAs and lncRNAs might be potential therapeutic targets for the treatment of CIBP.PMID:34364296 | DOI:10.1016/j.bbrc.2021.07.063
Source: Cell Research - August 7, 2021 Category: Cytology Authors: Jinrong Wei Qianshu Dou Futing Ba Guang-Yin Xu Guo-Qin Jiang Source Type: research
