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Cancer: Adenocarcinoma
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Total 766 results found since Jan 2013.
C‐Myc participates in β‐catenin–mediated drug resistance in A549/DDP lung adenocarcinoma cells
The aim of this study was to investigate c‐Myc and β‐catenin–mediated drug resistance in A549/DDP lung adenocarcinoma cells. Cisplatin sensitivity was determined by the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) toxicity assay. β‐Catenin and c‐Myc protein expression following cisplatin treatment were determined using western blotting and immunofluorescence. Flow cytometry was performed to detect cell cycle and apoptosis in A549, A549/DDP, and c‐Myc small interfering RNA (siRNA)–transfected A549/DDP cells before and after treatment with different doses of cisplatin. The me...
Source: APMIS - August 6, 2014 Category: Research Authors: Chengyao Xie, Yongqi Pan, Fengxia Hao, Yuan Gao, Zan Liu, Xiuwei Zhang, Lingling Xie, Guiyang Jiang, Qingchang Li, Enhua Wang Tags: Original Article Source Type: research
Abstract 4054: Elongation factor-2 kinase (eEF-2K) promotes cell invasion and epithelial mesenchymal transition through regulation of TG2-mediated signaling in human pancreatic cancer cells
Pancreatic ductal adenocarcinoma (PDAC) accounts for the majority of pancreatic cancer (PaCa) cases and is currently uncurable with poor prognosis/survival rates (∼4% 5-year survival). The extensive local tumor invasion, early metastasis/systemic dissemination and resistance to existing cancer therapies are the major characteristics of PaCa and the impediment to effective cure of this disease. Although PaCa has a well-defined spectrum of highly oncogenic lesions (e.g, mutations in K-RAS, p53, p16ink4a, and SMAD4/DPC4), effective therapies have not yet been developed. Therefore, novel molecular targets-based therapeutic s...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Ashour, A. A., Alpay, S. N., Gurbuz, N., Abdel-Aziz, A.-A. H., Mansour, A. M., Ozpolat, B. Tags: Tumor Biology Source Type: research
Knockdown of autophagy-related protein 6, Beclin-1, decreases cell growth, invasion, and metastasis and has a positive effect on chemotherapy-induced cytotoxicity in osteosarcoma cells
Abstract
Beclin-1, a well-known key regulator of autophagy, has been implicated in many disorders, including cancer, aging, and degenerative diseases. Previous studies demonstrated that Beclin-1 participated in tumorgenesis and was highly expressed in colorectal cancer cells, primary duodenal adenocarcinoma, and hepatocellular carcinoma cells, and overexpression of Beclin-1 could induce autophagic cell death in leukemia cells. However, the exact effects and molecular mechanisms of Beclin-1-mediated autophagy in osteosarcoma are still unknown up to now. Here, we evaluated the role of Beclin-1 in human osteosarcoma ...
Source: Tumor Biology - November 27, 2014 Category: Cancer & Oncology Source Type: research
Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis
This study aimed to clarify the clinical and biological role of two key metastasis-associated long non-coding RNAs (lncRNAs) in GC. We analyzed the expression levels of two lncRNAs—Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) and HOX-Antisense Intergenic RNA (HOTAIR)—by real-time reverse transcription PCR in 300 gastric tissues (150 GC and 150 adjacent normal mucosa), and in seven GC cell lines. Functional characterization for the role of HOTAIR in GC was performed by small interfering RNA (siRNA) knockdown, followed by series of in-vitro and in-vivo experiments. Expression of both lncRNAs wa...
Source: Carcinogenesis - November 29, 2014 Category: Cancer & Oncology Authors: Okugawa, Y., Toiyama, Y., Hur, K., Toden, S., Saigusa, S., Tanaka, K., Inoue, Y., Mohri, Y., Kusunoki, M., Boland, C. R., Goel, A. Tags: Original Manuscript Source Type: research
P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis.
In conclusion, P62 links resveratrol-induced autophagy to apoptosis. P62 blocks apoptosis by inhibiting Fas/Cav-1 complex formation, but RSV-induced autophagic degradation of P62 enables formation of Fas/Cav-1 complexes which then activate caspase-8-mediated Beclin-1 cleavage, resulting in translocation of the Beclin-1 C-terminal fragment to the mitochondria to initiate apoptosis.
PMID: 25596736 [PubMed - as supplied by publisher]
Source: Oncotarget - January 21, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Abstract 2642: EF2-kinase (EF2K): A novel molecular target in ovarian and pancreatic cancers
Ovarian cancer (OC) and Pancreatic ductal adenocarcinoma (PDAC) are the most aggressive and deadliest cancers and is currently incurable disease with the poorest prognosis and survival rates (4% and 30% 5-year survival rates, respectively). The poor prognosis is attributed to the extensive local tumor invasion and the resistance to existing cancer therapeutics, which are the major characteristics of both cancers and the impediment to effective cure this lethal diseases. Although both cancers have a well-defined spectrum of highly recurrent oncogenic lesions, including p53, c-myc, K-ras, CDKN2A /p16, TP53 and SMAD4/DPC4 eff...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Ashour, A., Erdogan, A., Alpay, S. N., Kahraman, N., Yuka, E., Lopez-Berestein, G., Ozpolat, B. Tags: Experimental and Molecular Therapeutics Source Type: research
miR-181c inhibits glycolysis by targeting hexokinase 2 in cancer-associated fibroblasts.
CONCLUSION: Transfection with miR-181 mimics can suppress glycolysis in CAFs by inhibiting HK2 expression.
PMID: 26607087 [PubMed - as supplied by publisher]
Source: Journal of Southern Medical University - November 20, 2015 Category: Universities & Medical Training Authors: Lan HB, Luo L, Qi XF, Gong YQ, Chen Y Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Down-regulation of anti-apoptotic genes in tumor cell lines is facilitated by suppression of OCT4B1
Conclusions It may possibly be concluded that suppression of OCT4B1 can lead to apoptosis in tumor cell lines and this is at least facilitated via down-regulation of examined anti-apoptotic genes. Accordingly, suppression of OCT4B1 may probably be considered as useful tool in cancer therapy and research.
Source: Advances in Medical Sciences - May 10, 2016 Category: Biomedical Science Source Type: research
Effects of RNAi-mediated TUSC3 silencing on radiation-induced autophagy and radiation sensitivity of human lung adenocarcinoma cell line A549 under hypoxic condition
This study examined the effects of RNAi-mediated TUSC3 silencing on radiation-induced autophagy and radiation sensitivity of human lung adenocarcinoma cell line A549 under hypoxic condition. Different CoCl2 concentrations were used to treat A549 cells and establish a CoCl2-induced hypoxic model of A549 cells. MTT and clone formation assays were used to determine the effects of different concentrations of CoCl2 on the growth and proliferation of A549 cells treated by different doses of X-ray irradiation. The siRNA-expressing vector was transfected by liposomes and for silencing ofTUSC3. Flow cytometry was used to measure ce...
Source: Tumor Biology - November 29, 2016 Category: Cancer & Oncology Source Type: research
IL-6 induced lncRNA MALAT1 enhances TNF- α expression in LPS-induced septic cardiomyocytes via activation of SAA3.
CONCLUSIONS: IL-6 induced MALAT1 upregulation in cardiomyocytes in response to LPS treatment. MALAT1 can enhance TNF-α expression at least partly via SAA3 in LPS-treated cardiomyocytes. MALAT1 upregulation is a mechanism of cardiomyocyte death in response to the LPS stimulation.
PMID: 28165557 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 8, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Protein phosphatase 2A (PP2A) inhibitor CIP2A indicates resistance to radiotherapy in rectal cancer
In conclusion, these results suggest that by contributing to radiosensitivity of cancer cells, low CIP2A protein expression level associates with a favorable response to long‐course (C)RT in rectal cancer patients.
Low CIP2A protein expression level associates with a favorable response to long‐course chemoradiotherapy in rectal cancer patients. Suppression of CIP2A transcription by siRNA sensitizes colorectal cancer cells to irradiation and decreases their survival in vitro.
Source: Cancer Medicine - February 14, 2018 Category: Cancer & Oncology Authors: Eva ‐Maria Birkman, Adam Elzagheid, Terhi Jokilehto, Tuulia Avoranta, Eija Korkeila, Jarmo Kulmala, Kari Syrjänen, Jukka Westermarck, Jari Sundström Tags: Original Research Source Type: research
The long non-coding RNA MALAT1 is increased in renal ischemia-reperfusion injury and inhibits hypoxia-induced inflammation.
CONCLUSION: The expression of MALAT1 is increased in renal ischemia-reperfusion injury. It is likely that MALAT1 inhibits the hypoxia-induced inflammatory response through the NF-κB pathway.
PMID: 30277425 [PubMed - in process]
Source: Renal Failure - October 3, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Influence of lncRNA MALAT1 on septic lung injury in mice through p38 MAPK/p65 NF- κB pathway.
CONCLUSIONS: The knockdown of lncRNA MALAT1 can significantly improve the septic lung injury in mice, whose mechanism may be related to its inhibition on the p38 MAPK/p65 NF-κB signaling pathway.
PMID: 30779099 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 21, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Clinicopathological and prognostic significance of nuclear UGDH localization in lung adenocarcinoma.
This study aimed to clarify relationships among UDP-glucose-6 dehydrogenase (UGDH) expression, clinicopathological factors, and the prognosis of patients, and to determine the role of UGDH in lung adenocarcinoma (AC). Firstly, UGDH expression and localization in 126 lung AC tissues were immunohistochemically studied, and associations with clinicopathological parameters and patients' prognosis were evaluated. Secondly, serum UGDH levels were measured in 267 lung cancer patients and 100 healthy controls. Finally, the effects of UGDH knockdown by siRNA on migration and invasion abilities were analyzed. As a result, nuclear UG...
Source: Biomed Res - February 23, 2019 Category: Research Authors: Hagiuda D, Nagashio R, Ichinoe M, Tsuchiya B, Igawa S, Naoki K, Satoh Y, Murakumo Y, Saegusa M, Sato Y Tags: Biomed Res Source Type: research
LncRNA MALAT1 affects high glucose-induced endothelial cell proliferation, apoptosis, migration and angiogenesis by regulating the PI3K/Akt signaling pathway.
CONCLUSIONS: Inhibiting lncRNA MALAT1 can promote endothelial cell proliferation, migration and angiogenesis and repress endothelial cell apoptosis simultaneously, whose mechanism may be related to the activation of the PI3K/Akt signaling pathway.
PMID: 31646587 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 26, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
