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Cancer: Adenocarcinoma
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Total 766 results found since Jan 2013.
Abstract 764: A role for GLI1 in the development of multidrug resistance in rhabdomyosarcoma (RMS) cells
RMS is the most common sarcoma of childhood. About 30% of patients with localized tumors will recur following treatment. The outcome for patients with recurrent RMS remains poor. Therefore, development of chemotherapy resistance during RMS therapy represents an important problem and novel approaches to prevent or reverse drug resistance are essential. Activation of multidrug transporter genes, including MDR1, MRP1, LRP and TAP1 represents an important mechanism for drug resistance in RMS. However, the mechanism of expression of multidrug resistance genes in RMS is incompletely understood. Recent reports have suggested a ro...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Yoon, J. W., Lamm, M., Leong, K.-F., Iannaccone, S., Iannaccone, P., Walterhouse, D. Tags: Experimental and Molecular Therapeutics Source Type: research
Abstract 1126: Tristetraprolin inhibits Twist1-induced cancer cell migration
This study demonstrates that TTP plays a critical role in EMT process. Overexpression of TTP in ovarian cancer cells decreased the expression of mesenchymal markers (N-cadherin and Vimentin), increased the expression of epithelial marker (E-cadherin), and inhibited cell migration and invasion activities. On the contrary, inhibition of TTP by siRNA decreased the expression of E-cadherin, increased the expression of N-cadherin and Vimentin, and promoted cell migration and invasion. The cDNA microarray analysis revealed that Twist1 was significantly down-regulated in TTP-overexpressed cells. Twist1 mRNA contains ARE within it...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Cho, W. J., Yoon, N. A., Vo, M.-T., Min, Y. J., Park, J. W. Tags: Tumor Biology Source Type: research
Abstract 1155: Chemoresistance acquisition by ovarian adenocarcinoma cells due to microenvironment
Epithelial Ovarian Carcinoma is characterized by high frequency of recurrence (70% of patients) and carboplatin resistance acquisition. We recently showed that Carcinoma-Associated-Mesenchymal Stem Cells (CA-MSC) are involved in ovarian tumor growth via the facilitation of angiogenesis in the tumor site as well as in ovarian cancer chemoresistance acquisition. Our aim is to identify the mechanisms by which CA-MSC activate tumor cells signaling pathway for both effects. First we showed that factors released by CA-MSC are able to induce angiogenic cytokines (IL-6, IL-8 and VEGF) synthesis by tumor cells in a cell line specif...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Thibault, B., Castells, M., Mihas, D., Genre, L., Gandy, C., Mery, E., Delord, J. P., Couderc, B. C. Tags: Tumor Biology Source Type: research
Abstract 2244A: Prion protein cross-talks with Notch1 to promote pancreatic ductal adenocarcinoma progression
In this study, we would like to investigate whether PrP also involves other signal transduction pathway in PDACs, especially Notch pathway.
Using immunoprecipitation and immunocytometry, we investigated the binding partners for PrP in several PDAC cell lines and found that PrP associates with Notch1 but not with Notch2 or Notch3 in cytoplasm and cell membrane. The association of PrP and Notch1 was further validated by confocal microscopy. Silencing PrP by siRNA not only decreased PrP expression, but also decreased Notch1 in the cytoplasm and the nuclear localized cleaved Notch1. Knocking down PrP in PDAC cells with high le...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Wang, Y., Huang, D., Zhou, L., Xin, W. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2330: Transcription factor MAZ promotes cell growth and aggressive behavior of human pancreatic cancer cells
Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cancer in the United States and the eighth worldwide. PDAC is most aggressive type of cancer that spreads rapidly and is seldom detected in its early stages as signs and symptoms may not appear until pancreatic cancer is quite advanced. MAZ (Myc-associated zinc-finger protein) or SAF1 (Serum amyloid A activating factor 1) gene is a member of multiple Cys2-His2-type zinc finger proteins that are activated in response to various inflammatory signals and may act as a transcription factor with dual roles in transcription initiation and termination. Deregulation ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Maity, G., Sarkar, S., Dhar, K., Dhar, G., Haque, I., Banerjee, S. K., Banerjee, S. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2343: Role of calreticulin in the regulation of MALAT-1 expression in mouse adenocarcinoma cells
Calreticulin (CRT) is a ubiquitously expressed protein, with both calcium binding and chaperone activity. CRT is involved in quality control process during the folding and maturation of proteins in ER. Recently, we showed that overexpression of CRT resulted in the development of metastatic lung adenocarcinoma. In order to examine genes involved in the development of lung cancer we carried out microarray analysis on RNA isolated from mouse lung tumors versus control. In this screen we observed a significant increase in long noncoding RNA (LncRNA) MALAT-1 in the lungs of CRT overexpressing mouse models. MALAT-1 is a LncRNA t...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Massaeli, H., Viswanathan, D., Pillai, D., Mesaeli, N. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2350: Inhibition of Gli1 as a novel therapeutic target for lung squamous cell carcinoma
Conclusions: Our data suggest that Hh pathway downstream factor Gli1 expression is essential for cell proliferation and colony formation in lung SCC. Gli1 is not regulated by canonical Hh pathway regulators, whereas PI3K, ERK, and TGF pathways are involved in its regulation. Blocking Gli1 function is a novel therapeutic strategy for lung SCC treatment.
Citation Format: Chunli Shao. Inhibition of Gli1 as a novel therapeutic target for lung squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Can...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Shao, C. Tags: Molecular and Cellular Biology Source Type: research
Abstract 3152: Integrin {alpha}6{beta}1 dependent collective cell migration in prostate cancer metastasis
In this study, we optimized the growth and retrieval of tumor cells from 3-dimensional matrigel cultures, to determine the role of integrin α6β1, α6pβ1 and α3β1 in DU145 prostate tumor cell collective migration. The DU145 prostate tumor cells embedded in growth factor reduced matrigel, grew robust networks within 24 hours and contained extensive branching structures. The network formation was shown to be dependent on integrin α6β1 expression as determined by specific knockdown of α6β1 over a 24 hour period using 25nM siRNA targeting. Interestingly, the knockdown of α3β1 integrin had no observable effect on the ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Rubenstein, C. S., Gard, J., Nagle, R. B., Landowski, T. H., Cress, A. E. Tags: Tumor Biology Source Type: research
Abstract 3355: Inhibiting glyoxylase 1 as a strategy to target highly glycolytic cancer cells
Cancer cells typically display altered glucose metabolism characterized by a preference of aerobic glycolysis (Warburg effect) resulting in higher levels of glycolytic waste including methylglyoxal (MG). GLO1 (Glyoxalase 1) functions in the detoxification of MG: MG reacts with glutathione to form hemithioacetal, which is converted into S-D-Lactoylglutathione by GLO1 and further metabolised into D-lactate by GLO2. When not detoxified, MG acts as a cytotoxic reagent by forming DNA- and protein-adducts (advanced glycation end products = AGEs) that subsequently lead to cell death. Therefore, GLO1 has been discussed as a potent...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Gruenewald, S., Steckel, M., Timmermann, A., Rehwinkel, H., Steigemann, P., Zacharias, S., Walter, A., Bauser, M., Haegebarth, A. Tags: Molecular and Cellular Biology Source Type: research
Abstract 3526: The mTORC2 component RICTOR plays a key role in lung cancer cell growth
RICTOR (Rapamycin-insensitive companion of mTOR protein) is a key component of mTORC2 (the mammalian target of rapamycin complex 2). One of the most-recognized targets for RICTOR-mTORC2 is AKT (Ser473). RICTOR also carries functions independent of mTORC2. RICTOR signaling has been suggested to play key roles in regulating cancer cell migration, invasion and metastasis in breast, ovarian, colorectal cancers and gliomas. The potential roles of RICTOR in lung cancer remain to be elucidated. We first examined the expression profile of RICTOR in primary lung tumor specimens and in lung cancer cell lines by immunohistochemistry....
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Cheng, H., Zou, Y., Borczuk, A., Qiu, W., Piperdi, B., Kim, M., Halmos, B., Perez–Soler , R. Tags: Molecular and Cellular Biology Source Type: research
Abstract 4026: Attenuation of pancreatic cancer cell migration and invasion through a targeted inhibition of the Rac GEF Vav1
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of human cancer, due in large part to a high incidence of metastasis and resistance to conventional chemotherapies. As such, new therapies are needed to halt the metastatic process. The proto-oncogene Vav1 is ectopically expressed in over half of human pancreatic cancers, and its expression correlates with a poor prognosis in humans and promotes survival and transformation in isolated tumor cells. We have found that Vav1, through its GEF activity towards Rac1, also potently induces migration by pancreatic tumor cells. In addition, Vav1 also signals thr...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Razidlo, G. L., Magnine, C., Sletten, A. C., Hurley, R. M., McNiven, M. A. Tags: Tumor Biology Source Type: research
Abstract 4456: Aurora-A is a downstream target of RAS and forms a positive feedback regulation loop with NF-{kappa}B in non-small cell lung cancer
Previous studies have shown that inhibition of Aurora-A reduces mutant RAS oncogenic activity and that both Aurora-A and RAS activate NF-κB pathway through phosphorylation of IkBa and upregulation of GSKa, respectively. Here we show that Aurora-A expression and kinase activity are regulated by activating mutation of KRAS. Blockage of NF-κB by IκB-S32/36A abrogated KRAS-induced Aurora-A expression and kinase activity. Furthermore, we demonstrated that NF-κB directly bound to Aurora-A promoter and induces Aurora-A transcription. In addition, depletion of Aurora-A by siRNA and pharmacological inhibitor MLN8237 suppresses ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Kim, D., Kanai, M., Zheng, X., Zheng, D., Coppola, D., Cheng, J. Q. Tags: Molecular and Cellular Biology Source Type: research
Abstract 4609: MEF2 plays a critical role in RENCA macrobead-induced tumor cell growth inhibition
In this study, we evaluated the expression and role of MEF2 in regulating cell proliferation in mouse (RENCA) and human cell lines (J82, MCF7) in response to RENCA macrobeads. Freely growing RENCA target cells transiently transfected with a MEF2 transcriptional response element and exposed to conditioned media from variously aged macrobeads demonstrated increased response element activation in parallel with the increasing age of the macrobeads. Similarly, growth inhibition of the freely growing RENCA cells increased with older macrobeads. Suppression of the expressed MEF2 isoforms in target RENCA cells, either individually...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Martis, P. C., Dudley, A., Laramore, M. A., Smith, B. H., Gazda, L. S. Tags: Experimental and Molecular Therapeutics Source Type: research
Abstract 4911: NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor
Conclusion: Our study clearly shows that NU7441, a novel DNA-PKcs inhibitor, is a potent radio-sensitizer in p53-dificient lung cancer cells and highlights the promise of NU7441 in targeted cancer treatment.
Citation Format: Yu Lan, Zengfu Shang, Feng-Ming Hsu, Vasu Tumati, Benjamin P. Chen, Debabrata Saha. NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Lan, Y., Shang, Z., Hsu, F.-M., Tumati, V., Chen, B. P., Saha, D. Tags: Tumor Biology Source Type: research
Abstract 5267: Pro-inflammatory CXCL8 signaling potentiates survival of K-Ras mutant colorectal cancer cells
Conclusions: CXCL8 signaling is elevated in K-Ras and PI3KCA mutant cancers. The up-regulation of autocrine CXCL8 signaling is linked to the promotion of cell survival, principally mediated through the inhibition of apoptosis and promotion of RTK signaling. The clinical relevance of CXCL8 signaling in modulating outcome of K-Ras mutant CRC to current treatments remains to be determined. However, CXCL8-directed therapies may be relevant as chemo-sensitizing agents in K-Ras and/or PIK3CA mutant tumors.
Citation Format: Laura M. Campbell, Olabode Oladipo, Pamela J. Maxwell, Daniel Longley, Richard H. Wilson, David JJ Waugh. P...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Campbell, L. M., Oladipo, O., Maxwell, P. J., Longley, D., Wilson, R. H., Waugh, D. J. Tags: Molecular and Cellular Biology Source Type: research
