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Cancer: Adenocarcinoma
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Total 766 results found since Jan 2013.
SPOCK2 gene expression is downregulated in pancreatic ductal adenocarcinoma cells and correlates with prognosis of patients with pancreatic cancer
CONCLUSION: The expression of SPOCK2 is downregulated in PDAC as a result of hypermethylation of its corresponding gene. SPOCK2 expression as well as the demethylation of its gene could be a potential marker for PDAC.PMID:37188984 | DOI:10.1007/s00432-023-04845-5
Source: Cancer Control - May 15, 2023 Category: Cancer & Oncology Authors: Ughur Aghamaliyev Kaifeng Su Maximilian Weniger Dominik Koch Jan G D'Haese Jens Werner Alexandr V Bazhin Source Type: research
TIMELESS promotes the proliferation and migration of lung adenocarcinoma cells by activating EGFR through AMPK and SPHK1 regulation
CONCLUSIONS: Our study revealed that siTIM could inhibited EGFR activation through activating AMPK and inhibiting SPHK1 expression, as well as influencing mitochondrial function and alter the ATP level; TIM's high expression in LUAD is an important factor and a potential key target in LUAD.PMID:37433364 | DOI:10.1016/j.ejphar.2023.175883
Source: European Journal of Pharmacology - July 11, 2023 Category: Drugs & Pharmacology Authors: Houqing Yin Zequn Wang Dan Wang Muhadaisi Nuer Mengyuan Han Peng Ren Shanwu Ma Chutong Lin Jingjing Chen Haocheng Xian Dongmei Ai Xuejun Li Shaohua Ma Zhiqiang Lin Yan Pan Source Type: research
SPOCK2 gene expression is downregulated in pancreatic ductal adenocarcinoma cells and correlates with prognosis of patients with pancreatic cancer
ConclusionThe expression of SPOCK2 is downregulated in PDAC as a result of hypermethylation of its corresponding gene. SPOCK2 expression as well as the demethylation of its gene could be a potential marker for PDAC.
Source: Journal of Cancer Research and Clinical Oncology - July 28, 2023 Category: Cancer & Oncology Source Type: research
Expression of bile acid receptor TGR5 in gastric adenocarcinoma.
In this study we determined the expression of TGR5 in gastric adenocarcinoma and examined the role of TGR5 in cell proliferation. Strong TGR5 staining was present in 12% of cases of intestinal metaplasia but in no cases of normal gastric epithelium (p<0.01). Moderate to strong TGR5 membranous and cytoplasmic staining was present in 52% of the intestinal but in only 25% of the diffuse subtype of adenocarcinomas (p<0.001). Kaplan-Meier univariate survival analysis revealed that moderate to strong TGR5 staining was associated with decreased patient survival (p<0.05). Treatment with taurodeoxycholic acid (TDCA, a bile...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - December 13, 2012 Category: Physiology Authors: Cao W, Tian W, Hong J, Li D, Tavares R, Noble L, Moss SF, Resnick MB Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
EPHB4 Biomarker in Esophageal Cancers
Esophageal cancer incidence is increasing and has few treatment options. In studying receptor tyrosine kinases associated with esophageal cancers, we have identified EPHB4 to be robustly overexpressed in cell lines and primary tumor tissues. In total, 94 squamous cell carcinoma, 82 adenocarcinoma, 25 dysplasia, 13 Barrett esophagus, and 25 adjacent or unrelated normal esophageal tissues were evaluated by immunohistochemistry. EPHB4 expression was significantly higher in all the different histologic categories than in adjacent normal tissues. In 13 esophageal cancer cell lines, 3 of the 9 SCC cell lines and 2 of the 4 adeno...
Source: Cancer Research - January 2, 2013 Category: Cancer & Oncology Authors: Hasina, R., Mollberg, N., Kawada, I., Mutreja, K., Kanade, G., Yala, S., Surati, M., Liu, R., Li, X., Zhou, Y., Ferguson, B. D., Nallasura, V., Cohen, K. S., Hyjek, E., Mueller, J., Kanteti, R., El Hashani, E., Kane, D., Shimada, Y., Lingen, M. W., Husain Tags: Molecular and Cellular Pathobiology Source Type: research
Lactate Dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas.
CONCLUSION: This study identifies LDHB as a regulator of cell growth in a subset of lung adenocarcinoma and may provide a novel therapeutic approach for treating lung cancer.
PMID: 23224736 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - December 26, 2012 Category: Cancer & Oncology Authors: McCleland ML, Adler AS, Deming L, Cosino E, Lee LB, Blackwood EM, Solon M, Tao J, Li L, Shames DS, Jackson EL, Forrest W, Firestein R Tags: Clin Cancer Res Source Type: research
Expression of bile acid receptor TGR5 in gastric adenocarcinoma
In this study, we determined the expression of TGR5 in gastric adenocarcinoma and examined the role of TGR5 in cell proliferation. Strong TGR5 staining was present in 12% of cases of intestinal metaplasia but in no cases of normal gastric epithelium (P < 0.01). Moderate to strong TGR5 membranous and cytoplasmic staining was present in 52% of the intestinal but in only 25% of the diffuse subtype of adenocarcinomas (P < 0.001). Kaplan-Meier univariate survival analysis revealed that moderate to strong TGR5 staining was associated with decreased patient survival (P < 0.05). Treatment with taurodeoxycholic acid (TDCA,...
Source: AJP: Gastrointestinal and Liver Physiology - February 15, 2013 Category: Gastroenterology Authors: Cao, W., Tian, W., Hong, J., Li, D., Tavares, R., Noble, L., Moss, S. F., Resnick, M. B. Tags: CALL FOR PAPERS Source Type: research
Mechanisms of EGF Regulation of COX-2 Through the STAT5 Signaling Pathway
in Human Lung Adenocarcinoma A549 Cells
Conclusion COX-2 expression is dependent on STAT5 phosphorylation. A second pathway does not require STAT5 phosphorylation. DOI: 10.3779/j.issn.1009-3419.2013.04.01
Source: Chinese Journal of Lung Cancer - April 16, 2013 Category: Cancer & Oncology Source Type: research
Identification of a lung adenocarcinoma cell line with CCDC6‐RET fusion gene and the effect of RET inhibitors in vitro and in vivo
This article is protected by copyright. All rights reserved.
Source: Cancer Science - April 11, 2013 Category: Cancer & Oncology Authors: Makito Suzuki, Hideki Makinoshima, Shingo Matsumoto, Ayako Suzuki, Sachiyo Mimaki, Koutatsu Matsushima, Kiyotaka Yoh, Koichi Goto, Yutaka Suzuki, Genichiro Ishii, Atsushi Ochiai, Koji Tsuta, Tatsuhiro Shibata, Takashi Kohno, Hiroyasu Esumi, Katsuya Tsuchi Tags: Original Article Source Type: research
