Abstract 4911: NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor

Conclusion: Our study clearly shows that NU7441, a novel DNA-PKcs inhibitor, is a potent radio-sensitizer in p53-dificient lung cancer cells and highlights the promise of NU7441 in targeted cancer treatment.
Citation Format: Yu Lan, Zengfu Shang, Feng-Ming Hsu, Vasu Tumati, Benjamin P. Chen, Debabrata Saha. NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4911. doi:10.1158/1538-7445.AM2014-4911

Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Lan, Y., Shang, Z., Hsu, F.-M., Tumati, V., Chen, B. P., Saha, D. Tags: Tumor Biology Source Type: research