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Cancer: Colorectal Cancer

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Total 1289 results found since Jan 2013.

A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway.
Conclusion:CP is a broad-spectrum inhibitor of human carcinoma cells in vitro, and it also exerts significant inhibition on gastric cancer cell growth in vivo. CP induces human gastric cancer apoptosis via activation of the ERK1/2 signaling pathway. PMID: 24241351 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - November 18, 2013 Category: Drugs & Pharmacology Authors: Wang HJ, Liu Y, Fan LQ, Han CL, Jiang Y, Cheng SJ, Li Y Tags: Acta Pharmacol Sin Source Type: research

Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation.
Abstract Silibinin, an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration. However, the molecular mechanisms responsible for these effects are not fully understood. We observed that silibinin significantly induced the expression of the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) in both p53 wild-type and p53-null cancer cell lines, suggesting that silibinin-induced NAG-1 up-regulation is p53-independent manner. Silibinin up-regulates EGR-1 expression. The ectopic expression of EGR...
Source: Chemico-Biological Interactions - January 16, 2014 Category: Molecular Biology Authors: Woo SM, Min KJ, Kim S, Park JW, Kim DE, Chun KS, Kim YH, Lee TJ, Kim SH, Choi YH, Chang JS, Kwon TK Tags: Chem Biol Interact Source Type: research

Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1
Conclusions: These data suggest that SPTAN1 levels decreased in concordance with MLH1 reduction and impaired cellular mobility in MLH1 deficient colon cancer cells. Therefore, aggressiveness of MLH1-positive CRC might be related to SPTAN1.
Source: Molecular Cancer - January 24, 2014 Category: Cancer & Oncology Authors: Inga HinrichsenBenjamin ErnstFranziska NuberSandra PassmannDieter SchäferVerena SteinkeNicolaus FriedrichsGuido PlotzStefan ZeuzemAngela Brieger Source Type: research

Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells
Conclusion: Our overall results demonstrate that mPEPCK is a useful predictor of a response to chemoradiotherapy in patients with rectal cancer.
Source: BMC Cancer - March 6, 2014 Category: Cancer & Oncology Authors: Ji-Won ParkSeung KimWon KimJun HongKyung-Hee KimHyun YeoJae LeeM KimJong KimSe YangDae KimJae OhJae ChoByong Yoo Source Type: research

PPARδ deficiency disrupts hypoxia‐mediated tumorigenic potential of colon cancer cells
Peroxisome proliferator‐activated receptor (PPAR) δ is highly expressed in colon epithelial cells and closely linked to colon carcinogenesis. However, the role of PPARδ in colon cancer cells in a hypoxic tumor microenvironment is not fully understood. We found that expression of the tumor‐promoting cytokines, IL‐8 and VEGF, induced by hypoxia (<1% O2) and deferoxamine (a hypoxia mimetic) was significantly attenuated in PPARδ‐deficient HCT116 colon cancer cells. Consequently, PPARδ‐knockout colon cancer cells exposed to hypoxia and deferoxamine failed to stimulate endothelial cell vascularization and macrop...
Source: Molecular Carcinogenesis - March 9, 2014 Category: Molecular Biology Authors: Eunshil Jeong, Jung Eun Koo, Sang Hyeon Yeon, Mi‐Kyoung Kwak, Daniel H. Hwang, Joo Young Lee Tags: Research Article Source Type: research

Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy.
CONCLUSION: SeV/dF/FIR showed strong tumor growth suppression with no significant side effects in an animal xenograft model, thus SeV/dF/FIR is potentially applicable for future clinical cancer treatment. PMID: 24764668 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 21, 2014 Category: Gastroenterology Authors: Matsushita K, Shimada H, Ueda Y, Inoue M, Hasegawa M, Tomonaga T, Matsubara H, Nomura F Tags: World J Gastroenterol Source Type: research

Interference of Skp2 effectively inhibits the development and metastasis of colon carcinoma.
Abstract Colon cancer is a common type of malignancy in the digestive system. The aim of the present study was to investigate the role of S-phase kinase-associated protein 2 (Skp2) in colon carcinoma and to identify whether depletion of Skp2 by Skp2‑RNA interference (RNAi) attenuates the proliferation and migration of colon carcinoma. Three pairs of small interfering (si)RNA were designed based on the Skp2 gene sequence and the most effective one was used to silence the Skp2 gene in SW620 cells. Subsequent to the interference, quantitative polymerase chain reaction and western blot analysis were used for detec...
Source: Molecular Medicine - June 15, 2014 Category: Molecular Biology Authors: Chen H, Mo X, Yu J, Huang S, Huang Z, Gao L Tags: Mol Med Rep Source Type: research

A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-8.
CONCLUSION: TIPE2 can inhibit caspase-8 activity in colon cancer cells. TIPE2 can regulate TLR4 inflammatory effect and inhibit further amplification of cascade reaction via caspase-8, which provides one new therapeutic target for clinical treatment schedule. PMID: 24934366 [PubMed - in process]
Source: Cancer Biomarkers : Section A of Disease Markers - January 1, 2014 Category: Cancer & Oncology Authors: Li XM, Su JR, Yan SP, Cheng ZL, Yang TT, Zhu Q Tags: Cancer Biomark Source Type: research

Inhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin.
CONCLUSION: Girdin knockdown enhances chemosensitivity of colorectal cancer cells to oxaliplatin via TOP2B down-regulation. These findings provide a promising approach to overcome the chemoresistance of colorectal cancer cells. PMID: 25009397 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - July 7, 2014 Category: Gastroenterology Authors: Zhang YJ, Li AJ, Han Y, Yin L, Lin MB Tags: World J Gastroenterol Source Type: research

Interleukin‐17 induces CC chemokine receptor 6 expression and cell migration in colorectal cancer cells
This study aimed to investigate the effect of IL‐17 on the cell migration of CRC cells. Human CRC HCT‐116 cells were used to study the effect of IL‐17 on CCR6 expression and cell migration in CRC cells. IL‐17 treatment induced migration of HCT‐116 cells across the Boyden chamber membrane and increased the expression level of the CCR6. Inhibition of CCR6 by small interfering RNA (siRNA) and neutralizing antibody inhibited IL‐17‐induced cell migration. By using specific inhibitors and short hairpin RNA (shRNA), we demonstrated that the activation of ERK and p38 pathways are critical for IL‐17‐induced CCR6 e...
Source: Journal of Cellular Physiology - September 9, 2014 Category: Cytology Authors: Chih‐Chien Chin, Cheng‐Nan Chen, Hsing‐Chun Kuo, Chung‐Sheng Shi, Meng Chiao Hsieh, Yi‐Hung Kuo, Shui‐Yi Tung, Kam‐Fai Lee, Wen‐Shih Huang Tags: Original Research Article Source Type: research

Ki-1/57 and CGI-55 ectopic expression impact cellular pathways involved in proliferation and stress response regulation.
Abstract Ki-1/57 (HABP4) and CGI-55 (SERBP1) are regulatory proteins and paralogs with 40.7% amino acid sequence identity and 67.4% similarity. Functionally, they have been implicated in the regulation of gene expression on both the transcriptional and mRNA metabolism levels. A link with tumorigenesis is suggested, since both paralogs show altered expression levels in tumor cells and the Ki-1/57 gene is found in a region of chromosome 9q that represents a haplotype for familiar colon cancer. However, the target genes regulated by Ki-1/57 and CGI-55 are unknown. Here, we analyzed the alterations of the global trans...
Source: Biochimica et Biophysica Acta - September 6, 2014 Category: Biochemistry Authors: Costa FC, Saito A, Gonçalves KA, Vidigal PM, Meirelles GV, Bressan GC, Kobarg J Tags: Biochim Biophys Acta Source Type: research

Cellular density‐dependent down‐regulation of EP4 prostanoid receptors via the up‐regulation of hypoxia‐inducible factor‐1α in HCA‐7 human colon cancer cells
Abstract Increases in prostaglandin E2 (PGE2) and cyclooxygenase‐2 (COX‐2) levels are features of colon cancer. Among the different E‐type prostanoid receptor subtypes, EP4 receptors are considered to play a crucial role in carcinogenesis by, for example, inducing COX‐2 when stimulated with PGE2. However, EP4 receptor levels and PGE2‐induced cellular responses are inconsistent among the cellular conditions. Therefore, the connections responsible for the expression of EP4 receptors were investigated in the present study by focusing on cell density‐induced hypoxia‐inducible factor‐1α (HIF‐1α). The express...
Source: Pharmacology Research and Perspectives - November 7, 2014 Category: Drugs & Pharmacology Authors: Sho Otake, Kenji Yoshida, Naofumi Seira, Christopher M. Sanchez, John W. Regan, Hiromichi Fujino, Toshihiko Murayama Tags: Original Article Source Type: research

Ki-1/57 and CGI-55 ectopic expression impact cellular pathways involved in proliferation and stress response regulation
Publication date: December 2014 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1843, Issue 12 Author(s): Fernanda C. Costa , Ângela Saito , Kaliandra A. Gonçalves , Pedro M. Vidigal , Gabriela V. Meirelles , Gustavo C. Bressan , Jörg Kobarg Ki-1/57 (HABP4) and CGI-55 (SERBP1) are regulatory proteins and paralogs with 40.7% amino acid sequence identity and 67.4% similarity. Functionally, they have been implicated in the regulation of gene expression on both the transcriptional and mRNA metabolism levels. A link with tumorigenesis is suggested, since both paralogs show altered expression le...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - November 11, 2014 Category: Molecular Biology Source Type: research

Abstract 120: Runx3 inhibited epithelial to mesenchymal transition promotes motility and invasiveness of colon cancer cells through reduction of ROS generation
In this study, we investigated the function of Runx3 in human colon cancer cells. The proliferation, migration, and invasion of colon cancer cells in response to using the Runx3 expression vector for various times were investigated using MTT, wound healing, and Matrigel invasion assay, respectively. The morphologic changes of colon cancer cells through the EMT process were monitored by immunofluorescence staining and Western blot assay for EMT markers Twist and Vimentin. We found that Runx3 overexpressing cell inhibited cell motility and invasiveness in colon cancer, and this process was enhanced by Runx3 siRNA. We observe...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Kim, B. R., Kang, M. H., Kim, J. L., Jang, Y. J., Lee, S. I., Kim, J. S., Oh, S. C. Tags: Tumor Biology Source Type: research

Abstract LB-258: Neutrophil extracellular traps sequester circulating tumor cells via beta 1 integrin mediated interactions
Conclusions: This study is the first to implicate β 1 integrin mediated interactions as a mechanism for tumor-NET adhesion. Cell surface expression of β 1 integrins on tumor cells was necessary for tumor cell adhesion to NETs both in vitro and in vivo. Analysis of NETs both in vitro and in vivo demonstrated β 1 integrin expression, implicating integrin hetero-dimerization as a possible adhesive mechanism. Citation Format: Sara Najmeh, Jonathan Cools-Lartigue, Stephen Gowing, Jonahan Spicer, Braedon McDonald, Betty Giannias, France Bourdeau, Paul Kubes, Lorenzo Edwin Ferri. Neutrophil extracellular traps sequester circul...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Najmeh, S., Cools-Lartigue, J., Gowing, S., Spicer, J., McDonald, B., Giannias, B., Bourdeau, F., Kubes, P., Ferri, L. E. Tags: Immunology Source Type: research