Abstract LB-258: Neutrophil extracellular traps sequester circulating tumor cells via beta 1 integrin mediated interactions

Conclusions: This study is the first to implicate β 1 integrin mediated interactions as a mechanism for tumor-NET adhesion. Cell surface expression of β 1 integrins on tumor cells was necessary for tumor cell adhesion to NETs both in vitro and in vivo. Analysis of NETs both in vitro and in vivo demonstrated β 1 integrin expression, implicating integrin hetero-dimerization as a possible adhesive mechanism.
Citation Format: Sara Najmeh, Jonathan Cools-Lartigue, Stephen Gowing, Jonahan Spicer, Braedon McDonald, Betty Giannias, France Bourdeau, Paul Kubes, Lorenzo Edwin Ferri. Neutrophil extracellular traps sequester circulating tumor cells via beta 1 integrin mediated interactions. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-258. doi:10.1158/1538-7445.AM2014-LB-258

Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Najmeh, S., Cools-Lartigue, J., Gowing, S., Spicer, J., McDonald, B., Giannias, B., Bourdeau, F., Kubes, P., Ferri, L. E. Tags: Immunology Source Type: research