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Total 3372 results found since Jan 2013.

Theranostical nanosystem‐mediated identification of an oncogene and highly effective therapy in hepatocellular carcinoma
In conclusion, the theranostic siRNA nanomedicine examined here possesses great theranostic potential for combined gene therapy and MRI diagnosis of HCC. This article is protected by copyright. All rights reserved.
Source: Hepatology - December 1, 2015 Category: Internal Medicine Authors: Yu Guo, Jing Wang, Lu Zhang, Shunli Shen, Ruomi Guo, Yang Yang, Wenjie Chen, Yiru Wang, Guihua Chen, Xintao Shuai Tags: Hepatobiliary Malignancies Source Type: research

Transforming growth factor-{beta}1 induces invasion ability of HSC-4 human oral squamous cell carcinoma cells through the Slug/Wnt-5b/MMP-10 signalling axis
Molecular mechanism underlying the invasion of oral cancer cells remains to be clarified. We previously demonstrated that transforming growth factor-β1 (TGF-β1) induces the expression of mesenchymal markers in human oral squamous cell carcinoma HSC-4 cells. Intriguingly, the expression of the epithelial–mesenchymal transition-related transcription factor Slug was also significantly upregulated upon TGF-β1 stimulation. However, the mechanism by which Slug transduces the TGF-β1-induced signal to enhance the invasiveness of HSC-4 cells is poorly understood. Proteomic analysis revealed that the expres...
Source: Journal of Biochemistry - May 30, 2016 Category: Biochemistry Authors: Hino, M., Kamo, M., Saito, D., Kyakumoto, S., Shibata, T., Mizuki, H., Ishisaki, A. Tags: Regular Papers Source Type: research

DJ-1 Expression in Cervical Carcinoma and its Effects on Cell Viability and Apoptosis.
CONCLUSIONS The aberrant up-regulation of DJ-1 expression might be an important step in the pathogenesis of cervical carcinoma. PMID: 27544688 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - August 22, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Effects of targeted silencing of FOXC1 gene on proliferation and in vitro migration of human non-small-cell lung carcinoma cells.
CONCLUSION: Silencing FOXC1 may evidently inhibit the migration of these cells by reversing the EMT process through suppressing cadherin, being associated with the expressions of extracellular MMPs. PMID: 27648121 [PubMed - as supplied by publisher]
Source: American Journal of Translational Research - September 22, 2016 Category: Research Tags: Am J Transl Res Source Type: research

Knockdown of S100A4 blocks growth and metastasis of anaplastic thyroid cancer cells in vitro and in vivo.
Abstract Anaplastic thyroid cancer (ATC) is a locally aggressive type of thyroid tumor with high rate of distant metastases. It is often incurable because it does not respond to radioiodine, radiotherapy, or chemotherapy. With conventional treatment, the median survival is about 6 months; therefore, new treatment options are needed. S100A4 is a calcium-binding protein related to the metastatic potential of carcinoma. Previous study has found S100A4 was overexpressed in human papillary thyroid carcinomas (PTC) tissues, and overexpression of S100A4 is associated with thyroid tumour invasion and metastasis. In the pr...
Source: Cancer Biomarkers : Section A of Disease Markers - September 25, 2016 Category: Cancer & Oncology Authors: Zhang K, Yu M, Hao F, Dong A, Chen D Tags: Cancer Biomark Source Type: research

YM155 Down-Regulates Survivin and Induces P53 Up-Regulated Modulator of Apoptosis (PUMA)-Dependent in Oral Squamous Cell Carcinoma Cells.
CONCLUSIONS YM155 is a potent inhibitor of progression of SCC9 cells, which could be due to attenuation of survivin, and activation of the PUMA/caspase-3 cellular signaling processes. This study suggests that YM155 may be a potential molecular target with therapeutic relevance for the treatment of OSCC. PMID: 28435150 [PubMed - in process]
Source: Medical Science Monitor - April 25, 2017 Category: Research Tags: Med Sci Monit Source Type: research

STAT3 regulates glycolysis via targeting hexokinase 2 in hepatocellular carcinoma cells.
This study examined whether STAT3 regulates HCC glycolysis through the HK2 pathway in HCC cells. Human HCC cell lines HepG2 and Hep3B cells were transfected with pcDNA3.1(+)-EGFP-STAT3, STAT3 siRNA and HK2 siRNA, respectively, or treated with rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), and the effects on STAT3 and HK2 expression and cell glycolysis were determined. STAT3 and HK2 expressions were evaluated by real-time polymerase chain reaction and Western blotting. The level of glycolysis metabolism was assessed by the determination of glucose consumption and lactate production.The results showed that ...
Source: Oncotarget - April 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Effects of microRNA-374 on proliferation, migration, invasion and apoptosis of human SCC cells by targeting Gadd45a through P53 signaling pathway.
This study investigated the effects of microRNA-374 (miR-374) on human squamous cell carcinoma (SCC) cell proliferation, migration, invasion, and apoptosis through P53 signaling pathway by targeting Gadd45a. Skin samples were collected from patients with skin SCC and normal skin samples. Expression of miR-374, Gadd45a, P53, P73, P16, c-myc, bcl-2, Bax, caspase-3 and caspase-9 were detected using qRT-PCR and western blotting. A431 and SCL-1 cells were divided into blank, negative control (NC), miR-374 mimics, miR374 inhibitors, siRNA-Gadd45a, and miR-374 inhibitors + siRNA-Gadd45a groups. Their proliferation, migration, inv...
Source: Bioscience Reports - July 5, 2017 Category: Biomedical Science Authors: Li XJ, Li ZF, Wang JJ, Han Z, Liu Z, Liu BG Tags: Biosci Rep Source Type: research

BRCA2 protects mammalian cells from heat shock.
CONCLUSION: BRCA2 has a protecting role against heat-induced cell death. BRCA2 might be a potential molecular target for hyperthermic cancer therapy. PMID: 28891354 [PubMed - as supplied by publisher]
Source: International Journal of Hyperthermia - September 13, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in  vitro through activation of the Hedgehog pathway.
CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway. Oncol Rep. 2017 Nov 02;: Authors: Zhuang H, Cao G, Kou C, Liu T Abstract Chemokine (C-C motif) ligand 2 (CCL2) has been shown to play an important role in the regulation of tumor cell growth, metastasis and host immune response. CCL2 preferentially binds to the C-C chemokine receptor type 2 (CCR2), which is expressed in various tissues. However, the role of the CCL2/CCR2 axis in hepatocellular carcinoma (HCC) invasion and its molecular mechanisms remain...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hypoxia Accelerates Aggressiveness of Hepatocellular Carcinoma Cells Involving Oxidative Stress, Epithelial-Mesenchymal Transition and Non-Canonical Hedgehog Signaling
Conclusion: Our findings indicate that hypoxia triggers ROS-mediated GLI1-dependent EMT progress and invasion of HCC cells through induction of NOX4 expression. Thus, hypoxia-driven ROS mediated non-canonical Hh signaling may play an important role in the initiation of EMT and provides a potential marker for cancer prevention and treatment.Cell Physiol Biochem 2017;44:1856 –1868
Source: Cellular Physiology and Biochemistry - December 13, 2017 Category: Cytology Source Type: research

CXCL12 gene silencing down-regulates metastatic potential via blockage of MAPK/PI3K/AP-1 signaling pathway in colon cancer
ConclusionThe silencing CXCL12 gene significantly inhibits the proliferation, invasion and angiogenesis ability of some types colon carcinoma cells through down-regulation of MAPK/PI3K/AP-1 signaling pathway.
Source: Clinical and Translational Oncology - January 5, 2018 Category: Cancer & Oncology Source Type: research

The Sineoculis Homeobox Homolog 1 (SIX1) Gene Regulates Paclitaxel Resistance by Affecting Reactive Oxygen Species and Autophagy in Human Hepatocellular Carcinoma Cell Line HepG2.
CONCLUSIONS Knockdown of SIX1 increased cell ROS levels and autophagy, promoted cell apoptosis, and enhanced TAX sensitivity of HepG2 cells. PMID: 29656300 [PubMed - in process]
Source: Medical Science Monitor - April 18, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Downregulation of RPN2 induces apoptosis and inhibits migration and invasion in colon carcinoma.
Authors: Bi C, Jiang B Abstract The morbidity of colorectal cancer (CRC) increases annualy, which accounts to higher mortality worldwide. Therefore, it is important to study the pathogenesis of colon cancer. Ribophorin II (RPN2), part of the N-oligosaccharyltransferase complex, is highly expressed in CRC. In the present study, we investigated whether RPN2 can regulate apoptosis, migration and invasion by RNA interference in CRC and sought to clarify the molecular mechanism involved. Based on previous research, an abnormal high expression of RPN2 was observed in CRC tissues and cell lines by real-time (RT)-PCR, im...
Source: Oncology Reports - May 12, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of forkhead Box protein A1 on cell proliferation regulating and EMT of cervical carcinoma.
CONCLUSIONS: FOXA1 expression increased in cervical cancer. Inhibition of FOXA1 expression blocked the proliferation of cervical cancer, promoted tumor cell apoptosis, suppressed the occurrence of EMT and VEGF production, and can regulate cervical cancer metastasis. FOXA1 can be used as a new molecular biological target for cervical cancer diagnosis and treatment. PMID: 30468461 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research