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Total 3372 results found since Jan 2013.

RNAi targeting CXCR4 inhibits proliferation and invasion of esophageal carcinoma cells
: CXC chemokine receptor 4 was found to be expressed by many different types of human cancers and its expression has been correlated with tumor aggressiveness, poor prognosis and resistance to chemotherapy. However the effect of CXCR4 on the esophageal carcinoma cells remains unclear, the present study explored the effects of CXCR4siRNA on proliferation and invasion of esophageal carcinoma KYSE-150 and TE-13 cells. Two siRNA sequence targeting CXCR4 gene were constructed and then were transfected into KYSE-150 and TE-13 cells by LipofectamineTM2000. Changes of CXCR4 mRNA and protein were analyzed byqRT-PCR and Western blot...
Source: Diagnostic Pathology - June 24, 2013 Category: Pathology Authors: Tao WangYanfang MiLinping PianPing GaoHong XuYuling ZhengXiaoyan Xuan Source Type: research

CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells.
In this study, we investigated the expression of CDK-associated Cullin 1 (CAC1) in lung cancer, the effect of CAC1 on the proliferation of human lung cancer A549 cells, and the activation of signaling pathways of mitogen-activated protein kinases (MAPKs). Results showed that CAC1 expression was higher levels in human lung carcinoma than normal lung tissue, and CAC1 siRNA reduced the proliferation of lung cancer A549 cells by decreasing cell activity and cell division in vitro. The proportion of cells treated with CAC1 siRNA increased in the G1 phase and decreased in the S and G2/M phase, indicative of G1 cell cycle arrest....
Source: Biochemical and Biophysical Research communications - June 24, 2013 Category: Biochemistry Authors: Chen TJ, Gao F, Yang T, Thakur A, Ren H, Li Y, Zhang S, Wang T, Chen MW Tags: Biochem Biophys Res Commun Source Type: research

Apurinic/Apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues.
Conclusion APE-1 is overexpressed and associated with COX-2 expression and VEGF production in esophageal cancer tissues. PMID: 24284961 [PubMed - as supplied by publisher]
Source: Am J Physiol Gastroi... - November 27, 2013 Category: Gastroenterology Authors: Nagoya H, Futagami S, Shimpuku M, Tatsuguchi A, Wakabayashi T, Yamawaki H, Kodaka Y, Kawagoe T, Watarai Y, Makino H, Miyashita M, Tsuchiya S, Crowe SE, Sakamoto C Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues
Apurinic/apyrimidinic endonuclease-1 (APE-1) is a key enzyme responsible for DNA base excision repair and is also a multifunctional protein such as redox effector for several transcriptional factors. Our study was designed to investigate APE-1 expression and to study its interaction with cyclooxygenase (COX)-2 expression and VEGF production in the esophageal cancer. The expression of APE-1, COX-2, monocyte chemoattractant protein (MCP)-1, CC-chemokine receptor (CCR)2, and VEGF were evaluated by immunohistochemistry in 65 human esophageal squamous cell carcinoma (ESCC) tissues. Real-time PCR and Western blotting were perfor...
Source: AJP: Gastrointestinal and Liver Physiology - February 1, 2014 Category: Gastroenterology Authors: Nagoya, H., Futagami, S., Shimpuku, M., Tatsuguchi, A., Wakabayashi, T., Yamawaki, H., Kodaka, Y., Kawagoe, T., Watarai, Y., Makino, H., Miyashita, M., Tsuchiya, S., Crowe, S. E., Sakamoto, C. Tags: CALL FOR PAPERS Source Type: research

Cisplatin inhibits proliferation of cervical carcinoma cell line by up-regulating Stat1 expression.
CONCLUSION: The expression of Stat1 is associated with DDP sensitivity in cervical cancer cells, and Stat1 silencing can increase the sensitivity to DDP and c-Myc expression of the cells. PMID: 25613616 [PubMed - in process]
Source: Journal of Southern Medical University - January 20, 2015 Category: Universities & Medical Training Authors: Lei RL, Xiao SS, Xue M Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

P70S6K and Elf4E Dual Inhibition Is Essential to Control Bladder Tumor Growth and Progression in Orthotopic Mouse Non-muscle Invasive Bladder Tumor Model.
Authors: Chi BH, Kim SJ, Seo HK, Seo HH, Lee SJ, Kwon JK, Lee TJ, Chang IH Abstract We investigated how the dual inhibition of the molecular mechanism of the mammalian target of the rapamycin (mTOR) downstreams, P70S6 kinase (P70S6K) and eukaryotic initiation factor 4E (eIF4E), can lead to a suppression of the proliferation and progression of urothelial carcinoma (UC) in an orthotopic mouse non-muscle invasive bladder tumor (NMIBT) model. A KU-7-luc cell intravesically instilled orthotopic mouse NMIBC model was monitored using bioluminescence imaging (BLI) in vivo by interfering with different molecular components ...
Source: Journal of Korean Medical Science - March 3, 2015 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Proapoptotic and Antiapoptotic Proteins of the Bcl-2 Family Regulate Sensitivity of Pancreatic Cancer Cells Toward Gemcitabine and T-Cell–mediated Cytotoxicity
In conclusion, expression of Bcl-2, Bcl-xL, and Bax in pancreatic tumor cells determines sensitivity towards both Gem-mediated and CTL-mediated toxicity. Bcl-2 silencing could be exploited therapeutically in tumor vaccine approaches.
Source: Journal of Immunotherapy - March 19, 2015 Category: Allergy & Immunology Tags: Basic Studies Source Type: research

β-Elemene inhibits the proliferation of esophageal squamous cell carcinoma by regulating long noncoding RNA-mediated inhibition of hTERT expression
The study aimed to clarify the relationship between β-elemene, a long noncoding RNA (lncRNA), and human telomerase reverse transcriptase (hTERT) in esophageal carcinoma ECA-109 cells. The proliferation of ECA-109 cells was measured using a CCK-8 kit and flow cytometry. PCR microarray and real-time RT-PCR were designed to determine lncRNA expression in ECA-109 cells before and after treatment with β-elemene. Western blot was used to detect the hTERT level after the differentially expressed lncRNAs in ECA-109 cells were interfered with small interfering RNA (siRNA). On treatment with β-elemene, the proliferation of ECA-10...
Source: Anti-Cancer Drugs - April 4, 2015 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research

Effect of EphA7 Silencing on Proliferation, Invasion and Apoptosis in Human Laryngeal Cancer Cell Lines Hep-2 and AMC-HN-8
Conclusion: Up-regulation of EphA7 was observed in human LSCC samples and down-regulation of EphA7 effectively suppressed laryngeal carcinoma cell growth and promoted its apoptosis. Thus, EphA7 has a critical role in modulating cell growth and apoptosis, which serves as a potential therapeutic target in human LSCC.Cell Physiol Biochem 2015;36:435-445
Source: Cellular Physiology and Biochemistry - May 8, 2015 Category: Cytology Source Type: research

Silencing of TMSG1 enhances metastasis capacity by targeting V-ATPase in breast cancer.
In conclusion, silencing of TMSG1 increased V-ATPase activity, decreased extracellular pH and in turn the activation of secreted MMP-2, which ultimately promoted metastasis capacity of breast cancer cell. PMID: 25973015 [PubMed - in process]
Source: Clinical Genitourinary Cancer - May 17, 2015 Category: Cancer & Oncology Authors: Zi Y, Zhao W, Zhou J, He H, Xie M Tags: Int J Clin Exp Pathol Source Type: research

Interference of STAT 5b expression enhances the chemo-sensitivity of gastric cancer cells to gefitinib by promoting mitochondrial pathway-mediated cell apoptosis.
This study aimed to detect the expression of STAT 5b in gastric cancer cells and analyze the role and possible mechanism of STAT 5b in the chemo-sensitivity of gastric cancer cells to gefitinib. A total of 69 patients with gastric carcinomas were analyzed for the expression of STAT 5b in carcinomas and para-carcinomas by immunohistochemistry. Cultured MGC-803 and MKN-45 cells were exposed to gefitinib and/or STAT 5b siRNA. Mitochondrial proteins including Bcl-2, Bax, caspase-3 and caspase-9 were extracted using special kits for detecting mitochondrial pathway-related apoptosis proteins. The results showed that STAT 5...
Source: Oncology Reports - May 23, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Abstract 2043: SATB1 (special AT-rich binding protein 1) as a putative therapeutic target in colorectal cancer
In this study, we have analyzed the function of SATB1 in primary and in established colorectal cancer cell lines and determined the therapeutic relevance of SATB1-specific gene knockdown approaches by RNA interference (RNAi). In CRC cells, an RNAi-mediated knockdown of the SATB1 was achieved by transient or by stable transfection with specific siRNAs or shRNAs-encoding plasmids, each leading to markedly reduced SATB1 mRNA and protein levels. SATB1 knockdown caused an inhibition of proliferation, a deceleration of cell cycle progression and pro-apoptotic effects. Further analyses revealed effects of SATB1 on multiple signal...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Fromberg, A., Rabe, M., Linnebacher, M., Aigner, A. M. Tags: Molecular and Cellular Biology Source Type: research

Abstract 5474: PD-L1 regulates cisplatin chemoresistance in head and neck squamous cell carcinoma
In conclusion, we have identified a novel role for PD-L1 in the development of chemoresistance through its interaction with the MRN complex, which plays a major role in the repair of chemo-induced DNA DSB. Therapies aimed at blocking PD-L1 show great promise because of their ability to enhance both chemotherapeutics and the anti-tumor immune response.Citation Format: Randall S. Ruffner, Andrew Ramsey, Bert W. O'Malley, Daqing Li. PD-L1 regulates cisplatin chemoresistance in head and neck squamous cell carcinoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Ap...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Ruffner, R. S., Ramsey, A., O'Malley, B. W., Li, D. Tags: Experimental and Molecular Therapeutics Source Type: research

Expression of survivin in adenoid cystic carcinoma of the lacrimal gland and the effect of intervention with arsenic trioxide in vitro.
Authors: Pan Y, Xing Y, Wang H Abstract The aim of the present study was to investigate the role of survivin in adenoid cystic carcinoma of the lacrimal gland (LGACC) and the effect of arsenic trioxide (As2O3) intervention in vitro. In total, 13 patients with LGACC were recruited from Renmin Hospital of Wuhan University between 2007 and 2012. The patients were divided into different groups, namely tumor-node-metastasis (TNM)1-2 and TNM3-4, according to the TNM classification. A total of eight samples were included in the TNM1-2 group, while five samples were included in the TNM3-4 group. In addition, six patients t...
Source: Experimental and Therapeutic Medicine - November 18, 2015 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the 5(th) most common malignancy which is responsible for more than half million annual mortalities; also, it is the third leading cause of cancer related death. Unfavorable systemic side-effects of chemotherapeutic agents and susceptibility to the degradation of small interfering RNAs (siRNAs), which can knock down a specific gene involved in the disease, have hampered their clinical application. So, it could be beneficial to develop an efficient carrier for the stabilization and specific delivery of drugs and siRNA to cells. Targeted nanoparticles have gained considerab...
Source: World Journal of Gastroenterology : WJG - November 14, 2015 Category: Gastroenterology Authors: Varshosaz J, Farzan M Tags: World J Gastroenterol Source Type: research