Silencing of TMSG1 enhances metastasis capacity by targeting V-ATPase in breast cancer.

In conclusion, silencing of TMSG1 increased V-ATPase activity, decreased extracellular pH and in turn the activation of secreted MMP-2, which ultimately promoted metastasis capacity of breast cancer cell. PMID: 25973015 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/25973015?dopt=Abstract

Source: Clinical Genitourinary Cancer - May 17, 2015 Category: Cancer & Oncology Authors: Zi Y, Zhao W, Zhou J, He H, Xie M Tags: Int J Clin Exp Pathol Source Type: research