Prominent mitochondrial pathology in a case of refractory dermatomyositis: coincidence or concause?
We report on clinical, immunological, radiological, and myopathological findings of a case of severe, treatment-refractory anti-Mi-2-positive DM.ResultsA 77-year-old woman developed anti-Mi-2 DM with severe diffuse muscle weakness associated with abundant mitochondrial abnormalities at muscle biopsy, beside the typical features of inflammatory myopathy. The patient was poorly responsive to multiple-line therapies and finally anti-JAK (anti-Janus activated kinase) was administered, leading to partial clinical improvement.DiscussionGiven the usual satisfactory treatment response and favorable outcome of anti-Mi-2 DM, we supp...
Source: Neurological Sciences - November 13, 2023 Category: Neurology Source Type: research
Inflammatory biomarkers in polymyositis/dermatomyositis patients with interstitial lung disease: a retrospective study
CONCLUSIONS: The identification of peripheral blood T lymphocyte subsets, especially Treg cells, and blood count in DM/PM appears to be useful in the comprehensive assessment of clinical lung involvement.PMID:37938089 | DOI:10.1080/03007995.2023.2281501 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 8, 2023 Category: Research Authors: Jin Zhao Xiao-Jing Guo Lei Shi Source Type: research
Pathogenicity of functionally activated PD-1 < sup > + < /sup > CD8 < sup > + < /sup > cells and counterattacks by muscular PD-L1 through IFN γ in myositis
In conclusion, PD-1+CD8+ T cells rather than PD-1-CD8+ T cells were a pathogenic subset of IIMs. Muscular PD-L1 was regulated by IFNγ and exerted protective properties in IIMs.PMID:37931332 | DOI:10.1016/j.jaut.2023.103131 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 6, 2023 Category: Allergy & Immunology Authors: Hirokazu Sasaki Natsuka Umezawa Takuji Itakura Hideyuki Iwai Shinsuke Yasuda Source Type: research
Pathogenicity of functionally activated PD-1 < sup > + < /sup > CD8 < sup > + < /sup > cells and counterattacks by muscular PD-L1 through IFN γ in myositis
In conclusion, PD-1+CD8+ T cells rather than PD-1-CD8+ T cells were a pathogenic subset of IIMs. Muscular PD-L1 was regulated by IFNγ and exerted protective properties in IIMs.PMID:37931332 | DOI:10.1016/j.jaut.2023.103131 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 6, 2023 Category: Allergy & Immunology Authors: Hirokazu Sasaki Natsuka Umezawa Takuji Itakura Hideyuki Iwai Shinsuke Yasuda Source Type: research
Low utilization of statins in patients with dermatomyositis/polymyositis and hyperlipidemia: a multicenter USA-based study (2013 –2023)
ConclusionThere is a marked disparity in statin initiation between DM/PM-HLD and RA-HLD patients, accompanied by elevated mortality in DM/PM-HLD non-users. It is imperative for further research to elucidate this discrepancy and formulate patient-centric cardiovascular guidelines for DM/PM-HLD patients.Key Points• Statin initiation among patients with DM/PM-HLD is significantly lower than that with RA-HLD.• Mortality rates within the statin initiator DM/PM-HLD were significantly lower compared to non-statin DM/PM-HLD initiators, spanning multiple time intervals. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 6, 2023 Category: Rheumatology Source Type: research
The Personal Financial Burden Associated with Idiopathic Inflammatory Myopathies
Idiopathic inflammatory myopathies (IIMs) are a group of rare systemic autoimmune diseases. IIMs include dermatomyositis, polymyositis, immune-mediated necrotizing myopathy, overlap syndrome, and inclusion body myositis (IBM). Although IIMs are rare with an annual incidence ranging from 14.0 to 17.4 per 100,000, the cost burden of IIMs on United States (US) healthcare spending is high. [13,18,19] The estimated total costs associated with IIMs, specifically with dermatomyositis and polymyositis, range from $533 to $702 million a year. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - November 3, 2023 Category: Neurology Authors: Catherine Hua, Abhiram R. Bhashyam, Manuel Lubinus, Lynn Wilson, Salman Bhai Source Type: research
Idiopathic Inflammatory Myopathies
AbstractIdiopathic inflammatory myopathies (IIMs) are a diverse group of diseases characterized by proximal muscle weakness and inflammation in skeletal muscle. Phenotypically, the subtypes include dermatomyositis, polymyositis, inclusion body myositis, and amyopathic dermatomyositis. The most common IIM in children is juvenile dermatomyositis (JDM). In contrast to adult dermatomyositis (DM), children are likely to have frequent relapses, vasculopathy, and long-term metabolic and other complications like lipodystrophy, insulin resistance, and calcinosis. Significant advances in our understanding of pathogenesis, disease co...
Source: Indian Journal of Pediatrics - November 3, 2023 Category: Pediatrics Source Type: research
Paraneoplastic dermatomyositis associated with urothelial cancer: report of a case and systematic review of the literature
ConclusionIn conclusion, our study provides knowledge and understanding for identifying specific risk factors in patients with the coexistence of bladder cancer and DM/PM and their management. During the initial and follow-up screening, age, gender, and the clinicopathological subgroup of myositis should be considered to ensure proper management of the condition. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - October 31, 2023 Category: Cancer & Oncology Source Type: research
Clinicopathological prognostic characteristics and long ‑term outcomes of patients with breast cancer and collagen disorder in comparison to those without collagen disorder
Oncol Lett. 2023 Sep 29;26(5):495. doi: 10.3892/ol.2023.14082. eCollection 2023 Nov.ABSTRACTCollagen disorders are chronic autoimmune diseases with a complex clinical course; however, the risk of breast cancer in patients with collagen disorders remains unclear. The present study aimed to investigate long-term outcomes in women with breast cancer and collagen disorders. A total of 25 patients with breast cancer and collagen disorders who were treated between January 2004 and December 2011 were included. The clinicopathological factors, treatment, recurrence-free survival (RFS) and overall survival (OS) were reviewed. The m...
Source: Cancer Control - October 19, 2023 Category: Cancer & Oncology Authors: Kazuo Matsuura Akihiko Osaki Yuki Ichinose Akihiro Fujimoto Ayaka Sakakibara Asami Nukui Hideki Yokogawa Hiroko Shimada Aya Asano Masahiro Ohara Hiroshi Ishiguro Takao Takahashi Toshiaki Saeki Source Type: research
Clinicopathological prognostic characteristics and long ‑term outcomes of patients with breast cancer and collagen disorder in comparison to those without collagen disorder
Oncol Lett. 2023 Sep 29;26(5):495. doi: 10.3892/ol.2023.14082. eCollection 2023 Nov.ABSTRACTCollagen disorders are chronic autoimmune diseases with a complex clinical course; however, the risk of breast cancer in patients with collagen disorders remains unclear. The present study aimed to investigate long-term outcomes in women with breast cancer and collagen disorders. A total of 25 patients with breast cancer and collagen disorders who were treated between January 2004 and December 2011 were included. The clinicopathological factors, treatment, recurrence-free survival (RFS) and overall survival (OS) were reviewed. The m...
Source: Oncology Letters - October 19, 2023 Category: Cancer & Oncology Authors: Kazuo Matsuura Akihiko Osaki Yuki Ichinose Akihiro Fujimoto Ayaka Sakakibara Asami Nukui Hideki Yokogawa Hiroko Shimada Aya Asano Masahiro Ohara Hiroshi Ishiguro Takao Takahashi Toshiaki Saeki Source Type: research
