Pompe disease misdiagnosed as polymyositis
Pract Neurol. 2023 Oct 18:pn-2023-003935. doi: 10.1136/pn-2023-003935. Online ahead of print.ABSTRACTLate-onset Pompe disease manifests predominantly in the proximal lower limbs and may be mistaken for an inflammatory myopathy. A 46-year-old man with acromegaly had an 8-year history of progressive weakness. His myopathy was initially attributed to the acromegaly, but severe progression prompted a muscle biopsy, which suggested an inflammatory myopathy. However, his weakness progressed despite treatment for polymyositis. His muscle ultrasound scan pattern was more suggestive of Pompe disease than polymyositis, and Pompe dis...
Source: Practical Neurology - October 18, 2023 Category: Neurology Authors: Antonio Edvan Camelo-Filho Manoel Ricardo Alves Martins Jorge Luiz de Brito de Souza Rebeca Bessa Maur ício Paulo Ribeiro N óbrega Source Type: research
Pompe disease misdiagnosed as polymyositis
Pract Neurol. 2023 Oct 18:pn-2023-003935. doi: 10.1136/pn-2023-003935. Online ahead of print.ABSTRACTLate-onset Pompe disease manifests predominantly in the proximal lower limbs and may be mistaken for an inflammatory myopathy. A 46-year-old man with acromegaly had an 8-year history of progressive weakness. His myopathy was initially attributed to the acromegaly, but severe progression prompted a muscle biopsy, which suggested an inflammatory myopathy. However, his weakness progressed despite treatment for polymyositis. His muscle ultrasound scan pattern was more suggestive of Pompe disease than polymyositis, and Pompe dis...
Source: Practical Neurology - October 18, 2023 Category: Neurology Authors: Antonio Edvan Camelo-Filho Manoel Ricardo Alves Martins Jorge Luiz de Brito de Souza Rebeca Bessa Maur ício Paulo Ribeiro N óbrega Source Type: research
Detection of Myositis Autoantibodies by Multi-Analytic Immunoassays in a Large Multicenter Cohort of Patients with Definite Idiopathic Inflammatory Myopathies
CONCLUSIONS: Since MSAs are mostly mutually exclusive, multi-specific antibody profiling seems effective for a targeted clinical-serologic approach to the diagnosis of IIMs.PMID:37835823 | DOI:10.3390/diagnostics13193080 (Source: Cancer Control)
Source: Cancer Control - October 14, 2023 Category: Cancer & Oncology Authors: Anna Ghirardello Mariele Gatto Chiara Franco Elisabetta Zanatta Roberto Padoan Luana Ienna Nicoletta Gallo Margherita Zen Ingrid E Lundberg Michael Mahler Andrea Doria Luca Iaccarino Source Type: research
Detection of Myositis Autoantibodies by Multi-Analytic Immunoassays in a Large Multicenter Cohort of Patients with Definite Idiopathic Inflammatory Myopathies
CONCLUSIONS: Since MSAs are mostly mutually exclusive, multi-specific antibody profiling seems effective for a targeted clinical-serologic approach to the diagnosis of IIMs.PMID:37835823 | PMC:PMC10572214 | DOI:10.3390/diagnostics13193080 (Source: Cancer Control)
Source: Cancer Control - October 14, 2023 Category: Cancer & Oncology Authors: Anna Ghirardello Mariele Gatto Chiara Franco Elisabetta Zanatta Roberto Padoan Luana Ienna Nicoletta Gallo Margherita Zen Ingrid E Lundberg Michael Mahler Andrea Doria Luca Iaccarino Source Type: research
Clinical profile of anti-NXP-2 antibody-positive inflammatory myositis and outcome in an Indian population
CONCLUSION: The current study shows that adult DM patients with anti-NXP-2 autoantibodies have a unique clinical phenotype. Its presentation differs between adult and JDM, even in different parts of the world. Muscle weakness is mild and responds to treatment. Dysphagia needs more time and aggressive IS for improvement as compared to other muscle involvement. Key Points • Anti-NXP-2 antibody presentation varied from adult to child, as in different parts of the world. • In Indian adult patients, non-specific skin manifestations were more common, whereas in JDM, specific skin features were common. • There was less like...
Source: Clinical Lung Cancer - October 6, 2023 Category: Cancer & Oncology Authors: Abhilasha Manwatkar Shivraj Padiyar Aswin Nair Avanish Jha Sathish Kumar Bijesh Yadav John Antony Jude Prakash John Kumar Das John Mathew Source Type: research
Clinical profile of anti-NXP-2 antibody-positive inflammatory myositis and outcome in an Indian population
CONCLUSION: The current study shows that adult DM patients with anti-NXP-2 autoantibodies have a unique clinical phenotype. Its presentation differs between adult and JDM, even in different parts of the world. Muscle weakness is mild and responds to treatment. Dysphagia needs more time and aggressive IS for improvement as compared to other muscle involvement. Key Points • Anti-NXP-2 antibody presentation varied from adult to child, as in different parts of the world. • In Indian adult patients, non-specific skin manifestations were more common, whereas in JDM, specific skin features were common. • There was less like...
Source: Clinical Breast Cancer - October 6, 2023 Category: Cancer & Oncology Authors: Abhilasha Manwatkar Shivraj Padiyar Aswin Nair Avanish Jha Sathish Kumar Bijesh Yadav John Antony Jude Prakash John Kumar Das John Mathew Source Type: research
Clinical profile of anti-NXP-2 antibody-positive inflammatory myositis and outcome in an Indian population
CONCLUSION: The current study shows that adult DM patients with anti-NXP-2 autoantibodies have a unique clinical phenotype. Its presentation differs between adult and JDM, even in different parts of the world. Muscle weakness is mild and responds to treatment. Dysphagia needs more time and aggressive IS for improvement as compared to other muscle involvement. Key Points • Anti-NXP-2 antibody presentation varied from adult to child, as in different parts of the world. • In Indian adult patients, non-specific skin manifestations were more common, whereas in JDM, specific skin features were common. • There was less like...
Source: Clinical Genitourinary Cancer - October 6, 2023 Category: Cancer & Oncology Authors: Abhilasha Manwatkar Shivraj Padiyar Aswin Nair Avanish Jha Sathish Kumar Bijesh Yadav John Antony Jude Prakash John Kumar Das John Mathew Source Type: research
Clinical profile of anti-NXP-2 antibody-positive inflammatory myositis and outcome in an Indian population
CONCLUSION: The current study shows that adult DM patients with anti-NXP-2 autoantibodies have a unique clinical phenotype. Its presentation differs between adult and JDM, even in different parts of the world. Muscle weakness is mild and responds to treatment. Dysphagia needs more time and aggressive IS for improvement as compared to other muscle involvement. Key Points • Anti-NXP-2 antibody presentation varied from adult to child, as in different parts of the world. • In Indian adult patients, non-specific skin manifestations were more common, whereas in JDM, specific skin features were common. • There was less like...
Source: Clinical Lung Cancer - October 6, 2023 Category: Cancer & Oncology Authors: Abhilasha Manwatkar Shivraj Padiyar Aswin Nair Avanish Jha Sathish Kumar Bijesh Yadav John Antony Jude Prakash John Kumar Das John Mathew Source Type: research
Clinical profile of anti-NXP-2 antibody-positive inflammatory myositis and outcome in an Indian population
CONCLUSION: The current study shows that adult DM patients with anti-NXP-2 autoantibodies have a unique clinical phenotype. Its presentation differs between adult and JDM, even in different parts of the world. Muscle weakness is mild and responds to treatment. Dysphagia needs more time and aggressive IS for improvement as compared to other muscle involvement. Key Points • Anti-NXP-2 antibody presentation varied from adult to child, as in different parts of the world. • In Indian adult patients, non-specific skin manifestations were more common, whereas in JDM, specific skin features were common. • There was less like...
Source: Clinical Breast Cancer - October 6, 2023 Category: Cancer & Oncology Authors: Abhilasha Manwatkar Shivraj Padiyar Aswin Nair Avanish Jha Sathish Kumar Bijesh Yadav John Antony Jude Prakash John Kumar Das John Mathew Source Type: research
Clinical profile of anti-NXP-2 antibody-positive inflammatory myositis and outcome in an Indian population
CONCLUSION: The current study shows that adult DM patients with anti-NXP-2 autoantibodies have a unique clinical phenotype. Its presentation differs between adult and JDM, even in different parts of the world. Muscle weakness is mild and responds to treatment. Dysphagia needs more time and aggressive IS for improvement as compared to other muscle involvement. Key Points • Anti-NXP-2 antibody presentation varied from adult to child, as in different parts of the world. • In Indian adult patients, non-specific skin manifestations were more common, whereas in JDM, specific skin features were common. • There was less like...
Source: Clinical Genitourinary Cancer - October 6, 2023 Category: Cancer & Oncology Authors: Abhilasha Manwatkar Shivraj Padiyar Aswin Nair Avanish Jha Sathish Kumar Bijesh Yadav John Antony Jude Prakash John Kumar Das John Mathew Source Type: research
