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Extensive Dystrophic Calcinosis Cutis: A Severe Complication of Polymyositis/Systemic Sclerosis Overlap Syndrome
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - November 22, 2017 Category: Rheumatology Tags: Images Source Type: research

Dropped Head Syndrome and the Presence of Rimmed Vacuoles in a Muscle Biopsy in Scleroderma-Polymyositis Overlap Syndrome Associated with Anti-Ku Antibody.
Authors: Takeshi Y, Mai Y, Kinjo M, Manabu J, Itsuro H Abstract A 66-year-old woman with a history of interstitial lung disease presented with a 3-month history of dropped head syndrome (DHS), followed by camptocormia and extremity weakness. A clinical examination revealed Raynaud phenomenon, arthralgia, distal skin sclerosis, and microbleeds in the nailfold capillaries. An anti-Ku antibody test was positive. A muscle biopsy revealed inflammatory myopathy with rimmed vacuoles (RVs). The diagnosis of scleroderma-polymyositis (SSc-PM) overlap syndrome was made. RVs on a muscle biopsy in a patient with inflammatory my...
Source: Internal Medicine - November 21, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Pregnancy outcomes in adult patients with dermatomyositis and polymyositis
The idiopathic inflammatory myopathies dermatomyositis (DM) and polymyositis (PM) are autoimmune diseases that can affect females of childbearing potential. We assessed pregnancy outcomes in DM and PM patients compared with the general obstetric population. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - November 20, 2017 Category: Rheumatology Authors: Kathleen D. Kolstad, David Fiorentino, Shufeng Li, Eliza F. Chakravarty, Lorinda Chung Source Type: research

GSE95772 Regulation of microRNA in myositis skeletal muscle after exercise (mRNA)
Contributors : Jessica F Boehler ; Marshall W Hogarth ; Matthew D Barberio ; James Novak ; Svetlana Ghimbovschi ; Kristy J Brown ; Li Munters ; Ingela Loell ; Yi-Wen Chen ; Helene Alexanderson ; Ingrid E Lundberg ; Kanneboyina NagarajuSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify changes in skeletal muscle microRNA expression after exercise and associate the identified microRNAs with mRNA and protein expression to disease-specific pathways in polymyositis and dermatomyositis (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - October 31, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE95735 Regulation of microRNA in myositis skeletal muscle after exercise (microRNA)
Contributors : Jessica F Boehler ; Marshall W Hogarth ; Matthew D Barberio ; James Novak ; Svetlana Ghimbovschi ; Kristy J Brown ; Li A Munters ; Ingela Loell ; Yi-Wen Chen ; Helene Alexanderson ; Ingrid E Lundberg ; Kanneboyina NagarajuSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructTo identify changes in skeletal muscle microRNA expression after exercise and associate the identified microRNAs with mRNA and protein expression to disease-specific pathways in polymyositis and dermatomyositis (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - October 31, 2017 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research

Clinical characteristics of patients with anti-aminoacyl-tRNA synthetase antibody positive idiopathic interstitial pneumonia
Anti-aminoacyl-tRNA synthetase (ARS) antibodies have been detected in patients with polymyositis/dermatomyositis (PM/DM) and are especially correlated with interstitial lung disease (ILD). The aim of this study was to clarify the clinical features of patients with anti-ARS antibody positive idiopathic interstitial pneumonias (IIPs). (Source: Respiratory Medicine)
Source: Respiratory Medicine - October 28, 2017 Category: Respiratory Medicine Authors: Hirokazu Yura, Noriho Sakamoto, Minoru Satoh, Hiroshi Ishimoto, Tetsuya Hanaka, Chiyo Ito, Tomoko Hasegawa, Shin Tanaka, Takuto Miyamura, Shota Nakashima, Atsuko Hara, Tomoyuki Kakugawa, Keishi Oda, Takashi Kido, Yasushi Obase, Yuji Ishimatsu, Kazuhiro Ya Source Type: research

Muscle ultrasonography is a potential tool for detecting fasciitis in dermatomyositis and polymyositis: comment on the article by Yoshida et  al
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Authors: Kavish J. Bhansing, Marieke H. Rosmalen, Baziel G. Engelen, Piet L. Riel, Sigrid Pillen, Madelon C. Vonk Tags: Letters Source Type: research

A Retrospective Medical Record Review of Utilization Patterns and Medical Resource Use Associated with Repository Corticotropin Injection among Patients with Rheumatologic Diseases in the United States
AbstractIntroductionRepository corticotropin injection (RCI) has anti-inflammatory and immune-modulatory effects and is approved for multiple indications, including several rheumatologic conditions. The aims of this nationally representative, retrospective, observational study were to describe patient characteristics, RCI treatment patterns, and barriers to RCI use in patients with rheumatologic disease, and to compare medical resource use (MRU) before and after RCI therapy.MethodsA random sample of US physicians was recruited to abstract the medical records of deidentified patients with a diagnosis of rheumatoid arthritis...
Source: Rheumatology and Therapy - October 25, 2017 Category: Rheumatology Source Type: research

A Randomized, Double-Blind, Placebo-Controlled Trial of Infliximab in Refractory Polymyositis and Dermatomyositis
To investigate in a pilot study the safety and efficacy of infliximab in patients with refractory dermatomyositis (DM) and polymyositis (PM). (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - October 14, 2017 Category: Rheumatology Authors: Adam Schiffenbauer, Megha Sawhney, Christine Castro, Angelina Pokrovnichka, Galen Joe, Joseph Shrader, Imelda Victoria Cabalar, Michael O. Harris-Love, Paul H. Plotz, Frederick W. Miller, Mark Gourley Source Type: research

Lipid-lowering agent-triggered dermatomyositis and polymyositis: a case series and literature review
AbstractLipid-lowering agent-triggered dermatomyositis (DM) or polymyositis (PM) is a rare event. Therefore, the aim of the present study was to describe a series of such cases. A retrospective cohort study of 5 DM and 4 PM cases triggered by prior exposure to lipid-lowering agents between 2001 and 2017 was carried out. All patients, except for two cases, had muscle biopsy compatible with inflammatory myopathy and no serum autoantibodies positive for anti-SRP or anti-HMGCoAR. Median age of the patients at time of diagnosis was 68  years. Seven patients had previously taken simvastatin 20 mg/day (exposure period f...
Source: Rheumatology International - October 12, 2017 Category: Rheumatology Source Type: research

Cardiovascular involvement in myositis
Purpose of review: The purpose of this review is to provide an update on cardiovascular involvement in idiopathic inflammatory myopathy (IIM). Studies from the past 18 months are identified and reviewed. Finally, the clinical impact of these findings is discussed. Recent findings: Epidemiological studies have revealed an increased risk of myocardial infraction and venous thromboembolism (VTE) – including deep venous thrombosis and pulmonary embolism – in adults with polymyositis or dermatomyositis compared to the general population, even after adjustment for potential confounders. This increased risk applies p...
Source: Current Opinion in Rheumatology - October 10, 2017 Category: Rheumatology Tags: MYOSITIS AND MYOPATHIES: Edited by Ingrid E. Lundberg and Jiri Vencovsky Source Type: research

Which nonautoimmune myopathies are most frequently misdiagnosed as myositis?
Purpose of review: To discuss the spectrum of nonautoimmune myopathies that may be misdiagnosed as autoimmune myopathy. Recent findings: Inherited myopathies, such as dysferlinopathy, calpainopathy, and facioscapulohumeral dystrophy may be misdiagnosed as autoimmune myopathy, especially when they have inflammatory muscle biopsies. Inclusion body myositis is frequently misdiagnosed as polymyositis when rimmed vacuoles are absent on muscle biopsy, and a careful neuromuscular evaluation is not performed. Hypothyroid myopathy can be misdiagnosed as immune-mediated necrotizing myopathy if thyroid function tests, including a T4...
Source: Current Opinion in Rheumatology - October 10, 2017 Category: Rheumatology Tags: MYOSITIS AND MYOPATHIES: Edited by Ingrid E. Lundberg and Jiri Vencovsky Source Type: research

Cardiopulmonary Manifestations of Collagen Vascular Diseases
AbstractPurpose of ReviewThe study aimed to illustrate the cardiopulmonary findings of the following collagen vascular diseases on cross-sectional imaging: rheumatoid arthritis, scleroderma (progressive systemic sclerosis), systemic lupus erythematosus, the inflammatory myopathies (polymyositis/dermatomyositis), and Sj ögren’s syndrome.Recent FindingsAlthough collagen vascular diseases can affect any part of the body, interstitial lung disease and pulmonary hypertension are the two most important cardiopulmonary complications and are responsible for the majority of morbidity and mortality in this patient populat...
Source: Current Rheumatology Reports - October 9, 2017 Category: Rheumatology Source Type: research

Risk factors for the recurrence of interstitial lung disease in patients with polymyositis and dermatomyositis: a retrospective cohort study
AbstractTo identify risk factors for the recurrence of interstitial lung disease (ILD) in patients with polymyositis (PM)/dermatomyositis (DM). Forty-four PM/DM-ILD patients who had been treated with glucocorticoid and/or immunosuppressive agents as a remission induction therapy were enrolled. The patients were first classified into two groups: the early recurrence group that recurred within 52  weeks, and the non-early recurrence group, which was further classified into the late recurrence group that recurred after 52 weeks, and the non-recurrence group. The characteristics and treatment regimen between the grou...
Source: Clinical Rheumatology - October 3, 2017 Category: Rheumatology Source Type: research

Comment on the article titled “Increased Incidence of Amyotrophic Lateral Sclerosis in Polymyositis: A Nationwide Cohort Study”
This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - October 3, 2017 Category: Rheumatology Authors: Konstantinos Parperis Tags: Letter to the editor Source Type: research

Reply
This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - October 3, 2017 Category: Rheumatology Authors: Chia ‐Chun Tseng, Shun‐Jen Chang, Wen‐Chan Tsai, Tsan‐Teng Ou, Cheng‐Chin Wu, Wan‐Yu Sung, Ming‐Chia Hsieh, Jeng‐Hsien Yen Tags: Reply to Letter to the editor Source Type: research

Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).
We examined the effect of additive expression of human AIRE (huAIRE) in a model of autoimmune diabetes in NOD mice. Unexpectedly, we observed that mice expressing augmented AIRE/Aire developed muscle-specific autoimmunity associated with incomplete maturation of mTECs together with impaired expression of Aire-dependent TRAs. This led to failure of deletion of autoreactive T cells together with dramatically reduced production of regulatory T cells in the thymus. In peripheral APCs, expression of costimulatory molecules was augmented. We suggest that levels of Aire expression need to be tightly controlled for maintenance of ...
Source: Journal of Autoimmunity - September 17, 2017 Category: Allergy & Immunology Authors: Nishijima H, Kajimoto T, Matsuoka Y, Mouri Y, Morimoto J, Matsumoto M, Kawano H, Nishioka Y, Uehara H, Izumi K, Tsuneyama K, Okazaki IM, Okazaki T, Hosomichi K, Shiraki A, Shibutani M, Mitsumori K, Matsumoto M Tags: J Autoimmun Source Type: research

Anti-HMGCR antibody positive myopathy shows bcl-2-positive lymphocyte follicles
Idiopathic inflammatory myopathies (IIM) are classified in five categories including polymyositis (PM), dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM), inclusion body myositis (IBM), and non-specific myositis. Muscle pathologies are required elements for the classification of IIM. In addition to the pathological patterns, more than 15 autoantibodies specific for myositis are already recognized. Recently, Anti-HMG-CoA reductase (HMGCR) antibody is reported to be one of the myositis-specific autoantibodies. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: T. Kurashige, N. Sumi, T. Kanbara, M. Ohta, T. Sugiura, H. Maruyama, T. Torii Source Type: research

Idiopathic inflammatory myopathies – increased expression of heat shock protein-90 in muscle tissue and plasma correlates with disease activity and skeletal muscle involvement
Heat shock proteins (Hsp) are chaperones playing important roles in skeletal muscle physiology, adaptation to exercise or stress, and activation of inflammatory cells. The aim of our study was to assess Hsp90 expression in muscle biopsies and plasma of patients with idiopathic inflammatory myopathies (IIM) and to characterize its association with IIM-related features. Total of 277 patients with IIM (dermatomyositis (DM, 104); polymyositis (PM, 104); cancer associated myositis (CAM, 42); necrotizing myopathy (IMNM, 27)), and 100 age-/sex-matched healthy individuals were included in Hsp90 plasma analysis by ELISA. (Source: N...
Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: J. Zamecnik, H. Storkanova, O. Krystufkova, M. Klein, H. Mann, L. Vernerova, M. Spiritovic, L. Senolt, J. Vencovsky, M. Tomcik Source Type: research

Differential type I and type II interferon signatures in primary inflammatory/dysimmune myopathies
Primary inflammatory/dysimmune myopathies (PIDM) include (i) polymyositis (PM)/inclusion body myositis (IBM), (ii) dermatomyositis (DM), (iii) necrotizing autoimmune myopathy, and (iv) overlap myositis (OM) . Type I α/β interferon signature was proposed as a characteristic feature of DM . Since OM and IBM differ from other PIDM by the presence of major histocompatibility complex (MHC)-2 expression by myofibers, we hypothesized that they are characterized by interferon (IFN)γ-mediated inflammation. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: M. Rigolet, C. Hou, B. Periou, P. Muhammad, R. Gherardi, Y. Baba Amer, F. Authier Source Type: research

Late onset multiple acyl-CoA dehydrogenase deficiency (MADD) myopathy misdiagnosed as polymyositis
We present a patient affected by a late onset MADD myopathy misdiagnosed for several years as polymyositis unresponsive to immunosuppressant therapies. The first symptoms started in his 40s with a slow progressive fatigability associated with occasional cramps in the calves; initial investigations showed high CPK level (1000 –1500 UI/L) without significant anomaly on muscle biopsy. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: A. Barp, R. Bellance, O. Rigal, C. Acquaviva-Bourdain, P. Lafor êt Source Type: research

P 41 Mitochondrial pathology in PM-Mito and sIBM
Polymyositis with mitochondrial pathology (PM-Mito) (Temiz et al., 2009) comprises a subgroup of inflammatory myopathies whose pathophysiological and clinical significance is not clear.Besides the lymphocytic infiltrates the PM-Mito (Siepmann et al., 2013) shares the histological finding of mitochondrial abnormalities with the sporadic inclusion body myositis (sIBM), in particular the occurrence of cytochrome-C-oxydase (COX)-deficient muscle fibres and subsarkolemmal accumulation of mitochondria (Rygiel et al., 2016; Lindgren et al., 2015). (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - September 8, 2017 Category: Neuroscience Authors: I. Schneider, P. Joshi, G. Stoltenburg-Didinger, T. Kraya, S. Zierz Tags: Poster Source Type: research

Clinicopathologic features of myositis patients with CD8-MHC-1 complex pathology
Conclusions: CD8-MHC-1 complex is present in patients with PM, IBM, or unclassifiable group. The data may serve as an argument for a trial of immunosuppressive treatment in p62-immunonegative patients with unclassifiable myositis. (Source: Neurology)
Source: Neurology - September 4, 2017 Category: Neurology Authors: Ikenaga, C., Kubota, A., Kadoya, M., Taira, K., Uchio, N., Hida, A., Maeda, M. H., Nagashima, Y., Ishiura, H., Kaida, K., Goto, J., Tsuji, S., Shimizu, J. Tags: Muscle disease ARTICLE Source Type: research

Facts and controversies in mixed connective tissue disease.
Authors: Martínez-Barrio J, Valor L, López-Longo FJ Abstract Mixed connective tissue disease (MCTD) is a systemic autoimmune rheumatic disease (SARD) characterised by the combination of clinical manifestations of systemic lupus erythematosus (SLE), cutaneous systemic sclerosis (SSc) and polymyositis-dermatomyositis, in the presence of elevated titers of anti-U1-RNP antibodies. Main symptoms of the disease are polyarthritis, hand oedema, Raynaud's phenomenon, sclerodactyly, myositis and oesophageal hypomobility. Although widely discussed, most authors today accept MCTD as an independent entity. Others,...
Source: Medicina Clinica - September 3, 2017 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Mortality and prognostic factors in idiopathic inflammatory myositis: a retrospective analysis of a large multicenter cohort of Spain
AbstractThe present study was undertaken to assess mortality, causes of death, and associated prognostic factors in a large cohort of patients diagnosed with idiopathic inflammatory myositis (IIM) from Spain. A retrospective longitudinal study was carried out in 467 consecutive patients with IIM, identified from 12 medical centers. Patients were classified as primary polymyositis, primary dermatomyositis (DM), overlap myositis, cancer-associated myositis (CAM), and juvenile idiopathic inflammatory myopathies. A total of 113 deaths occurred (24%) after a median follow-up time of 9.7  years. In the overall cohort, the 2...
Source: Rheumatology International - September 2, 2017 Category: Rheumatology Source Type: research

Myositis-associated Interstitial Lung Disease: Predictors of Failure of Conventional Treatment and Response to Tacrolimus in a US Cohort.
Abstract OBJECTIVE: Patients with myositis-associated interstitial lung disease (MA-ILD) are often refractory to conventional treatment, and predicting their response to therapy is challenging. Recent case reports and small series suggest that tacrolimus may be useful in refractory cases. METHODS: A retrospective cohort study of patients with MA-ILD comparing clinical characteristics between those who responded to or failed conventional treatment. In those who failed conventional treatment and received adjunctive tacrolimus, response to tacrolimus was measured by the improvement in myositis, ILD, and change i...
Source: J Rheumatol - September 1, 2017 Category: Rheumatology Authors: Sharma N, Putman MS, Vij R, Strek ME, Dua A Tags: J Rheumatol Source Type: research

Muscle ultrasound: a potential tool for detecting of fasciitis among dermatomyositis and polymyositis: Comment on article by Yoshida et al
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - August 29, 2017 Category: Rheumatology Authors: Kavish J. Bhansing, Marieke H. van Rosmalen, Baziel G. van Engelen, Piet L. van Riel, Sigrid Pillen, Madelon C. Vonk Tags: Letter to the Editor Source Type: research

GLIS3 and TYK2 Single Nucleotide Polymorphisms Are Not Associated with Dermatomyositis/Polymyositis in Chinese Han Population
Genetic Testing and Molecular Biomarkers , Vol. 0, No. 0. (Source: Genetic Testing and Molecular Biomarkers)
Source: Genetic Testing and Molecular Biomarkers - August 28, 2017 Category: Genetics & Stem Cells Authors: Liubing Li Si Chen Qian Wang Chanyuan Wu Xiaoting Wen Funing Yang Chenxi Liu Fengchun Zhang Yongzhe Li Source Type: research

Upregulation of Interleukin 21 and Interleukin 21 Receptor in Patients with Dermatomyositis and Polymyositis.
CONCLUSIONS: IL-21 expression is upregulated in patients with DM and PM in both muscle tissue and serum. In addition, IL-21R protein is highly expressed in affected muscle tissues of patients with DM and PM. IL-21 may play a pathogenic role through IL-21R in patients with DM and PM. PMID: 28836555 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - August 26, 2017 Category: General Medicine Authors: Liu T, Hou Y, Dai TJ, Yan CZ Tags: Chin Med J (Engl) Source Type: research

A review of inflammatory idiopathic myopathy focusing on polymyositis
Inflammatory idiopathic myopathies are a group of autoimmune diseases affecting predominantly the proximal skeletal muscles, with raised muscle enzymes, with or without skin involvement and extramuscular organ involvement. Autoantibodies help to characterize patients into different clinical phenotypes. Successful treatment necessitates controlling inflammation early with corticosteroids and invariably requires additional immunosuppressive therapy. This review focuses on the aetiology, pathogenesis, clinical presentation, investigations and management of patients presenting with inflammatory idiopathic myopathies, predomina...
Source: European Journal of Neurology - August 17, 2017 Category: Neurology Authors: K. E. N. Clark, D. A. Isenberg Tags: Review Article Source Type: research

Muscle biopsies in dermatomyositis and polymyositis: practical relevance of analyzing different levels of histological sections of the same muscular compartment
Conclusion: Our results stress the importance of evaluating different levels of histological sections from the same muscle biopsy block, in order to minimize possible false-negative results. In addition, the data reinforce that besides the inflammatory infiltrate, the other histological parameters analyzed also occur in foci, justifying the dissociation between these parameters and clinical patients.RESUMO Introdu ção: É frequente na prática médica encontrar achados histológicos com aspectos dentro da normalidade em biópsias musculares de pacientes com dermatomiosite (DM) ou...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - August 10, 2017 Category: Pathology Source Type: research

Polymyositis induced by PD-1 blockade in a patient in hepatitis B remission
Cancer cells evade cytotoxic T lymphocyte (CTL)-mediated destruction by taking advantage of a host's negative immune regulators, such as the PD-1 or CTLA-4 signaling pathways. Therefore, immune checkpoint inhibitors (ICIs), which target these pathways, have become a new way of overcoming cancers [1]. PD-1, which is a member of the CD28 family, negatively regulates effector T lymphocyte activation through the interaction with its major ligand, PD-L1 (B7-H1) [2]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - August 9, 2017 Category: Neurology Authors: Tatsuya Ogawa, Yosuke Ishitsuka, Hanako Koguchi-Yoshioka, Ryota Tanaka, Yasuhiro Fujisawa, Akiko Ishii, Akira Tamaoka, Manabu Fujimoto Tags: Letter to the Editor Source Type: research

Treatment of Fulminant Giant Cell Myocarditis Associated with Polymyositis Using a Left Ventricular Assist Device and Subsequent Corticosteroid and Immunosuppressive Therapy Leading to Remission.
Authors: Ooka J, Tanaka H, Hatani Y, Tsuji Y, Takeshige R, Mori S, Matsumoto K, Hara S, Tanaka H, Okita Y, Hirata KI Abstract A 58-year-old man with a recent history of generalized myalgia and muscle weakness was transferred to our hospital because of acute progressive dyspnea. The patient underwent left ventricular (LV) assist device (LVAD) implantation due to cardiogenic shock with a LV ejection fraction (LVEF) of 6%. The histological findings obtained from LV apex showed the infiltration of multinucleated giant cells and severe myocardial contusion. Combining this histological finding with our experienced neurol...
Source: Internal Medicine - August 8, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Statin ‐associated immune mediated necrotising myopathy: a New Zealand case series showing possible over‐representation in Pacific Islanders
ConclusionThis is the first case series of statin‐associated IMNM with a focus on Pacific Islanders, and raises the possibility that Pacific Islanders exposed to statins may be at increased risk of developing an immune mediated myopathy. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - August 7, 2017 Category: Internal Medicine Authors: Michelle Claudine Woolley, Simon Stebbings, John Highton Tags: Original Article Source Type: research

Ultrasound in Arthritis.
This article discusses the spectrum of ultrasound features of arthritides seen in rheumatoid arthritis and other connective tissue diseases in adults, such as Sjögren syndrome, lupus erythematosus, dermatomyositis, polymyositis, and juvenile idiopathic arthritis. Ultrasound findings in spondyloarthritis, osteoarthritis, and crystal-induced diseases are presented. Ultrasound-guided interventions in patients with arthritis are listed, and the advantages and disadvantages of ultrasound are discussed. PMID: 28774458 [PubMed - in process] (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - August 6, 2017 Category: Radiology Authors: Sudoł-Szopińska I, Schueller-Weidekamm C, Plagou A, Teh J Tags: Radiol Clin North Am Source Type: research

The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: another angle of the autoimmune mosaic.
We examined 2082 sera from patients with 16 different AID compared to 524 sera from geographically-matched healthy controls, for the presence and titres of anti-Ro/SSA and anti-La/SSB. All samples were also tested for a variety of anti-infectious agents' antibodies using the BioPlex 2200-immunoassay (Bio-Rad, USA). RESULTS: Anti-Ro/SSA was more prevalent, with significantly higher titre in 5 autoimmune diseases namely Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS) both primary and APS linked to SLE, systemic sclerosis (SSc) and primary biliary cirrhosis (PBC). Anti-La/...
Source: Clinical and Experimental Rheumatology - August 5, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Using multi-omics methods to understand dermatomyositis/polymyositis
Publication date: Available online 1 August 2017 Source:Autoimmunity Reviews Author(s): Siming Gao, Hui Luo, Huali Zhang, Xiaoxia Zuo, Li Wang, Honglin Zhu Idiopathic inflammatory myopathies (IIM) are a group of rare and heterogeneous autoimmune diseases, and the most common subtypes are dermatomyositis (DM) and polymyositis (PM). Despite extensive efforts, the underlying mechanism of IIM remains unclear. Recent efforts to understand the pathogenesis of IIM have included genomics, epigenetics, transcriptomics, proteomics and autoantibody studies. This review focuses on recent studies in DM/PM research based on multi-omics...
Source: Autoimmunity Reviews - August 5, 2017 Category: Allergy & Immunology Source Type: research

Case of Mycobacterium haemophilum misdiagnosed as Mycobacterium intracellulare due to one base insertion in the bacterial genome
We describe a case of cutaneous infection in a 68‐year‐old Japanese man with polymyositis. This was caused by M. haemophilum harboring one base insertion in gene sequence. At first, the causal microorganism was misidentified as M. intracellulare by COBAS® TaqMan® MAI test. However, poor growth on Ogawa media and growth enhancement on 7H11C agar around a hemin‐containing disk prompted us to reinvestigate the causal microorganisms, which were revealed to be M. haemophilum. Amplified polymerase chain reaction products were sequenced, and the 16S rRNA gene, rpoB, hsp65 and internal transcribed spacer region seque...
Source: The Journal of Dermatology - August 3, 2017 Category: Dermatology Authors: Rika Nishikawa, Yozo Yamada, Haruhisa Kanki, Hiroshi Matsuoka, Tatsuya Nakamura, Takumi Jikimoto, Mari Kusuki, Norihisa Ishii, Kenichiro Ohnuma, Kazue Nakanaga, Chikako Nishigori Tags: Concise Communication Source Type: research

Acute heart failure and rhabdomyolysis: a clue for the diagnosis of polymyositis with cardiac involvement.
We report the case of a 51-year-old male, with history of complete heart block, which required pacemaker implantation, and subsequently heart failure, presenting to the emergency department with worsening of dyspnea and peripheral edema. He was admitted to the Internal Medicine ward with acute heart failure and started on diuretic therapy. During hospitalization, he was discovered to have marked rhabdomyolysis. Examination revealed proximal symmetrical muscle weakness and arthralgia. The immunological study, electromyography and muscle biopsy confirmed polymyositis. The patient was started on prednisolone with clinical imp...
Source: Reumatismo - August 3, 2017 Category: Rheumatology Authors: Pinto-Lopes P, Carneiro-Leão L, Morais R, Pinheiro J, Vieira Lopes A, Bettencourt P Tags: Reumatismo Source Type: research

Using multi-omics methods to understand dermatomyositis/ polymyositis
Publication date: Available online 1 August 2017 Source:Autoimmunity Reviews Author(s): Siming Gao, Hui Luo, Huali Zhang, Xiaoxia Zuo, Li Wang, Honglin Zhu Idiopathic inflammatory myopathies (IIM) are a group of rare and heterogeneous autoimmune diseases, and the most common subtypes are dermatomyositis (DM) and polymyositis (PM). Despite extensive efforts, the underlying mechanism of IIM remains unclear. Recent efforts to understand the pathogenesis of IIM have included genomics, epigenetics, transcriptomics, proteomics and autoantibody studies. This review focuses on recent studies in DM/PM research based on multi-omics...
Source: Autoimmunity Reviews - August 1, 2017 Category: Allergy & Immunology Source Type: research

Comparisons of neutrophil ‐, monocyte‐, eosinophil‐, and basophil‐ lymphocyte ratios among various systemic autoimmune rheumatic diseases
This study was aimed to evaluate levels of neutrophil‐ (NLR), monocyte‐ (MLR), eosinophil‐ (ELR), and basophil‐lymphocyte ratio (BLR) and their association with inflammatory markers in systemic autoimmune rheumatic diseases (SARDs). A total of 1139 SARD patients and 170 healthy individuals were enrolled. Clinical and laboratory data were extracted. NLR and MLR were significantly increased, but BLR decreased in most SARD patients (p 
Source: APMIS - August 1, 2017 Category: Research Authors: Zaixing Yang, Zhiyu Zhang, Feng Lin, Yingpeng Ren, Donghong Liu, Renqian Zhong, Yan Liang Tags: Original Article Source Type: research

Diagnosis of dermatomyositis: Autoantibody profile and muscle pathology
Abstract Dermatomyositis (DM) is an idiopathic inflammatory myopathy, which not only affects skeletal muscle and skin, but it is also associated with arthritis/arthralgia, interstitial lung disease and cancer. The diagnostic criteria for myositis that Bohan and Peter formulated in 1975, which are often still used now, depend on the presence of a characteristic skin rash for classification of DM; without it, a diagnosis of polymyositis is given. However, advances in understanding the etiology of idiopathic inflammatory myopathies over the past few decades are impressive, encompassing discovery of myositis‐specific/associa...
Source: Clinical and Experimental Neuroimmunology - August 1, 2017 Category: Neurology Authors: Akinori Uruha, Shigeaki Suzuki, Ichizo Nishino Tags: Review Article Source Type: research

Hypercapnic respiratory failure during pregnancy due to polymyositis-related respiratory muscle weakness: a case report
ConclusionsNew-onset polymyositis during pregnancy presenting with respiratory failure is rare. Early diagnosis and prompt initiation of therapy is necessary to improve fetal and maternal outcomes. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - July 26, 2017 Category: General Medicine Source Type: research

Adult morphea en coup de sabre with accompanying regional polymyositis: A separate entity?
(Source: Australasian Journal of Dermatology)
Source: Australasian Journal of Dermatology - July 21, 2017 Category: Dermatology Authors: Donja Homayoon, Johannes Haybaeck, Elisabeth Aberer Tags: Letter to the Editors Source Type: research

Adult morphea en coup de sabre with accompanying regional polymyositis: A separate entity?
PMID: 28731498 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - July 21, 2017 Category: Dermatology Authors: Homayoon D, Haybaeck J, Aberer E Tags: Australas J Dermatol Source Type: research

Dermatomyositis Induced by Hepatitis B Virus-related Hepatocellular Carcinoma: A Case Report and Review of the Literature.
Authors: Chou JW, Lin YL, Cheng KS, Wu PY, Reanne Ju T Abstract Dermatomyositis or polymyositis as a paraneoplastic syndrome of hepatocellular carcinoma (HCC) is an uncommon event. Few cases have been reported in the literature. We herein report the case of a 55-year-old man with chronic hepatitis B and alcoholism who presented with skin rash. Abdominal computed tomography revealed multiple hypervascular liver tumors consistent with HCC. He subsequently developed dysphagia with proximal limb weakness. Laboratory tests and electromyography demonstrated inflammatory myopathy. We therefore diagnosed the patient with H...
Source: Internal Medicine - July 20, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Focal right atrial tachycardia with three foci in a patient with polymyositis
Publication date: Available online 18 July 2017 Source:Journal of Cardiology Cases Author(s): Kyoichiro Yazaki, Kenji Enta, Shohei Kataoka, Mitsuru Kahata, Asako Kumagai, Koji Inoue, Hiroshi Koganei, Masato Otsuka, Yasuhiro Ishii Cardiac involvement secondary to polymyositis is not infrequent. In addition, it sometimes presents various forms of arrhythmia, including atrial tachycardia (AT). A 72-year-old female who had 5-years history of polymyositis was referred to our clinic with symptomatic supraventricular tachycardia with 2:1 atrioventricular conduction. Electrophysiological study revealed a total of three focal AT i...
Source: Journal of Cardiology Cases - July 19, 2017 Category: Cardiology Source Type: research

Progressive hypoventilation due to mixed CD8 + and CD4 + lymphocytic polymyositis following tremelimumab - durvalumab treatment
ConclusionsThis case supports the hypothesis that muscle tissue is a target for lymphocytic infiltration in immune checkpoint inhibitor-associated polymyositis. Further insights into the autoimmune mechanism of PM will hopefully contribute to the prevention and treatment of this phenomenon. (Source: Journal for Immunotherapy of Cancer)
Source: Journal for Immunotherapy of Cancer - July 18, 2017 Category: Cancer & Oncology Source Type: research

HLA-DRB1 Alleles as Genetic Risk Factors for the Development of Anti-MDA5 Antibodies in Patients with Dermatomyositis.
CONCLUSION: DRB1*04:01 and *12:02 confer susceptibility to anti-MDA5 antibody production in DM, which cannot be explained by the SE hypothesis. PMID: 28711882 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 15, 2017 Category: Rheumatology Authors: Chen Z, Wang Y, Kuwana M, Xu X, Hu W, Feng X, Wang H, Kimura A, Sun L Tags: J Rheumatol Source Type: research

Clinical Utility of YKL-40 in Polymyositis/dermatomyositis-associated Interstitial Lung Disease.
Abstract OBJECTIVE: Interstitial lung disease (ILD) is involved in polymyositis/dermatomyositis (PM/DM), a disease associated with poor prognoses. Chitinase-3-like-1 protein (YKL-40) has pleiotropic biological activities involved in inflammation, cell proliferation, and tissue remodeling; however, the clinical application of YKL-40 remains limited. We investigated the clinical significance of YKL-40 in PM/DM-ILD. METHODS: Sixty-nine consecutive patients with PM/DM-ILD and 34 healthy controls were analyzed. We measured baseline and followup serum YKL-40 using an ELISA, evaluated the association of YKL-40 with ...
Source: J Rheumatol - July 15, 2017 Category: Rheumatology Authors: Hozumi H, Fujisawa T, Enomoto N, Nakashima R, Enomoto Y, Suzuki Y, Kono M, Karayama M, Furuhashi K, Murakami A, Inui N, Nakamura Y, Mimori T, Suda T Tags: J Rheumatol Source Type: research