Evaluation of coexisting polymyositis in feline myasthenia gravis: a case series
• Decrement of the CMAP occurs at low frequencies of stimulation in myasthenic cats.• Electrodiagnostics and muscles biopies may be recommended in feline MG.• Myasthenic cats‘ clinical presentation mimics late-onset MG in people.• MG in cats may be associated with polymyositis (PM) with an d without thymoma.• Feline MG may be a relevant animal model for study of thymoma and PM associations. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - June 16, 2017 Category: Neurology Authors: Vincent Mayousse, Aur élien Jeandel, Nicolas Blanchard-Gutton, Catherine Escriou, Kirsten Gnirs, G. Diane Shelton, Stéphane Blot Source Type: research
Ultrasound in Arthritis
This article discusses the spectrum of ultrasound features of arthritides seen in rheumatoid arthritis and other connective tissue diseases in adults, such as Sj ögren syndrome, lupus erythematosus, dermatomyositis, polymyositis, and juvenile idiopathic arthritis. Ultrasound findings in spondyloarthritis, osteoarthritis, and crystal-induced diseases are presented. Ultrasound-guided interventions in patients with arthritis are listed, and the advantages and disadvantages of ultrasound are discussed. (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - June 14, 2017 Category: Radiology Authors: Iwona Sudo ł-Szopińska, Claudia Schueller-Weidekamm, Athena Plagou, James Teh Source Type: research
Pulmonary-Limited Granulomatosis with Polyangiitis Coexisting with Mixed Connective Tissue Disease.
In conclusion, we should recognize that GPA may develop during the disease course of MCTD even after prolonged disease remission. To prevent progression to an irreversible state, physicians should consider a surgical lung biopsy for the diagnosis in patients suspected of having pulmonary-limited GPA. PMID: 28592713 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 10, 2017 Category: Research Authors: Ando M, Goto A, Yamasue M, Usagawa Y, Oka H, Shigenaga T, Kadota JI Tags: Tohoku J Exp Med Source Type: research
Potential role of autophagy in T ‑cell survival in polymyositis and dermatomyositis.
Potential role of autophagy in T‑cell survival in polymyositis and dermatomyositis. Mol Med Rep. 2017 Jun 06;: Authors: Shu X, Chen F, Peng Q, Lu X, Tian X, Wang Y, Wang G Abstract Peripheral blood T lymphocytopenia has previously been identified in polymyositis/dermatomyositis (PM/DM) patients. Therefore, the present study aimed to examine the potential role of autophagy in peripheral blood T cell survival in PM/DM patients. Transmission electron microscopy was used to detect the formation of autophagosomes of peripheral blood cluster of differentiation (CD)3+ T cells obtained from 24 patients ...
Source: Molecular Medicine Reports - June 8, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Quality of life correlates with muscle strength in patients with dermato- or polymyositis
AbstractThe aim of this study was to compare health-related quality of life (HQoL) in adults with dermatomyositis (DM) or polymyositis (PM) with a healthy control group and to assess whether muscle strength was associated with HQoL in patients with DM or PM. A cross-sectional study was performed and included 75 patients with DM or PM and 48 healthy controls. HQoL was assessed by the Short Form 36 questionnaire (SF-36). Muscle strength of the patients was assessed using the Manual Muscle Test-8 (MMT8). Covariables and possible confounding factors were collected by validated tools. Associations were determined in multiple li...
Source: Clinical Rheumatology - June 6, 2017 Category: Rheumatology Source Type: research
State of the art on nailfold capillaroscopy in dermatomyosistis and polymyositis
To provide an overview of the main naifold capillaroscopy (NFC) changes described in dermatomyositis (DM) and polymyositis (PM) and to discuss the current evidence supporting its clinical relevance and applications in daily practice. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - June 6, 2017 Category: Rheumatology Authors: Chiara Bertolazzi, Maurizio Cutolo, Vanessa Smith, Marwin Gutierrez Source Type: research
Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus erythematosus.
Authors: Nozawa K, Doe K, Uomori K, Sekigawa I, Takasaki Y, Yamaji K, Tamura N Abstract We previously reported that autoantibodies against the proliferating cell nuclear antigen protein (PCNA)-binding protein chromatin assembly factor-1 (CAF-1) are specifically found in patients with systemic lupus erythematosus (SLE). PCNA and its complex constituents elicit autoimmune responses in patients with SLE, suggesting that autoantibody diversification likely occurs owing to epitope spreading. Therefore, we sought to clarify whether patients with SLE exhibit an autoimmune response to Ribonuclease H2 (RNase H2), another PC...
Source: Autoimmunity - May 30, 2017 Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
Analysis of clinical features and prognostic factors in Chinese patients with rheumatic diseases in an intensive care unit
Conclusion SLE was the most frequent cause of ICU admission; infections are the leading causes prompting admission. RDs patients often had multi-organ involvement with a high mortality rate. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - May 26, 2017 Category: Rheumatology Source Type: research
Idiopathic inflammatory myositis
1206Objectives: Idiopathic inflammatory myositis (IIM) is a group of connective tissue diseases characterized by proximal muscle weakness. IIM is frequently accompanied with interstitial lung disease (ILD) and malignancy. 18F-FDG PET/CT, a standard tool for diagnosing malignancies, can also be used to detect inflammatory lesions. However, about its usefulness in clinical course from diagnosis to treatment evaluation of IIM has not been well established. The aim of this study is to investigate the significance of PET/CT in the detection of malignancy and evaluation of muscular and pulmonary involvement in patients with IIM....
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Li, Y., Wang, Q. Tags: Pulmonary Posters Source Type: research
["Therapy-resistant polymyositis" - is the diagnosis correct?]
We report the case of a 32-year-old woman with severely elevated serum creatine kinase (CK; 80,000 U/l) and progressive proximal pareses. As muscular biopsy showed inflammatory infiltrates, polymyositis was suspected and immunosuppressive treatment was initiated. However, clinical improvement could not be achieved. Gene sequencing of the DYSF-gene showed a previously unreported homozygous mutation. In summary, elevated serum CK and inflammatory infiltrates in the muscle biopsy are not specific for polymyositis, but may also occur in degenerative diseases (muscular dystrophy), such as dysferlinopathy. ...
Source: Zeitschrift fur Rheumatologie - May 18, 2017 Category: Rheumatology Authors: Ceccon G, Lehmann HC, Neuen-Jacob E, Meng G, Fink GR, Wunderlich G Tags: Z Rheumatol Source Type: research
Medical resource utilization in dermatomyositis/polymyositis patients treated with repository corticotropin injection, intravenous immunoglobulin, and/or rituximab
(Source: ClinicoEconomics and Outcomes Research)
Source: ClinicoEconomics and Outcomes Research - May 16, 2017 Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
Malignancy as a comorbidity in rheumatic diseases: a retrospective hospital-based study
AbstractPatients with Rheumatic diseases (RDs) are at an increased risk of malignancies compared with the general population. The aim of this study was to examine the relative frequency of several cancers in a single homogeneous cohort of patients with different RDs. Patients diagnosed with rheumatoid arthritis (RA), Ankylosing spondylitis (AS), Sj ögren’s syndrome (SS), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis (DM), or polymyositis were included. Out of 3982 adult residents admitted to the division of rheumatology, 61 malignancies were observed. The 2009 National Central Can...
Source: Clinical Rheumatology - May 16, 2017 Category: Rheumatology Source Type: research
A possible role of low regulatory T cells in anti-acetylcholine receptor antibody positive myasthenia gravis after bone marrow transplantation
Chronic graft-versus-host disease (GVHD) appears several months following allogenic hematopoietic stem cell transplantation (HSCT) and is clinically analogous to autoimmune disorder. Polymyositis is a common n... (Source: BMC Neurology)
Source: BMC Neurology - May 15, 2017 Category: Neurology Authors: Masahiko Fukatsu, Takenobu Murakami, Hiroshi Ohkawara, Shunichi Saito, Kazuhiko Ikeda, Suguru Kadowaki, Itaru Sasaki, Mari Segawa, Tomoko Soeda, Akihiko Hoshi, Hiroshi Takahashi, Akiko Shichishima-Nakamura, Kazuei Ogawa, Yoshihiro Sugiura, Hitoshi Ohto, Y Source Type: research
Idiopathic inflammatory myopathy and the risk of venous thromboembolism: a meta-analysis
This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95% CI...
Source: Rheumatology International - May 10, 2017 Category: Rheumatology Source Type: research
Polymyositis Involving the Uvula.
Authors: Breuer GS, Bogot N, Nesher G PMID: 28471589 [PubMed - in process] (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - May 5, 2017 Category: Journals (General) Tags: Isr Med Assoc J Source Type: research
Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population.
This study aimed to investigate the potential associations of these SNPs with DM/PM in a Chinese Han population. Five SNPs in TNFSF4 (rs2205960, rs844644, and rs844648) and ANKRD55 (rs6859219, rs7731626) genes were genotyped using the SequenomMassArray system in 2297 Chinese individuals. In total, 1017 DM/PM patients and 1280 gender-matched healthy controls were genotyped. No significant associations were observed in DM/PM patients for the five SNPs analyzed. The association between SNPs and interstitial lung disease (ILD) was also investigated. Both DM-ILD (Pc = 0.030, OR = 0.65, 95% CI: 0.47-0.88) and DM/PM-ILD (Pc = 0.0...
Source: Biomed Res - May 5, 2017 Category: Research Authors: Li L, Chen S, Wen X, Wang Q, Lv G, Li J, Yang F, Zhang F, Li Y Tags: Biomed Res Int Source Type: research
Analysis of sexual function of patients with dermatomyositis and polymyositis through self-administered questionnaires: a cross-sectional study
Conclusion s: This was the first study to identify sexual dysfunction in patients with DM/PM. Therefore, a multidisciplinary approach is essential for patients with idiopathic inflammatory myopathies, in order to provide prevention and care for their sexual life, providing a better quality of life, both for pa tients and their partners.Resumo Introdu ção: Até o presente momento, não há descrições na literatura da avaliação ginecológica e da função sexual em pacientes do sexo feminino com dermatomiosite (DM) e polimiosite (PM). Objetivos: Av...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
Inflammatory myopathies: Adult and paediatric experts unite for new response criteria
Nature Reviews Rheumatology 13, 321 (2017). doi:10.1038/nrrheum.2017.61 Author: Joanna Collison An international body of experts has developed standardized clinical response criteria to measure minimal, moderate and major improvements in adult patients with dermatomyositis or polymyositis and in children with juvenile dermatomyositis. The new response criteria, published simultaneously in Arthritis & Rheumatology and Annals of (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 4, 2017 Category: Rheumatology Authors: Joanna Collison Tags: Research Highlight Source Type: research
Camptocormia with Anti Ku antibodies in Inclusion Body Myositis (P2.112)
Conclusions:This case shows the first published case anti – ku antibodies present in IBM in association scleroderma with camptocormia. The definitive pathology and presentation were classic for IBM with exception of the camptocormia but does fit in scleroderma with anti-ku antibodies. Given the autoimmune component of her disease, patient was started on immunosuppressive medication which stabilized her physical exam.Disclosure: Dr. Jens has nothing to disclose. Dr. Kovacik Eicher has nothing to disclose. Dr. Kaur has nothing to disclose. (Source: Neurology)
Source: Neurology - April 17, 2017 Category: Neurology Authors: Jens, W., Eicher, M. E. K., Kaur, D. Tags: Myopathies & amp;amp; Myasthenia Gravis II Source Type: research
Intervention Effect on Fellow Muscle Biopsy Reading Accuracy in Inflammatory Myositis (P2.124)
Conclusions:Improved accuracy in the interpretation of IIM pathology amongst inexperienced muscle biopsy readers can support the use of a limited standardized educational program.Disclosure: Dr. Hamasaki has nothing to disclose. Dr. Jawdat has nothing to disclose. Dr. Kimple has nothing to disclose. Dr. Dimachkie has received personal compensation for activities with Pfizer, Depomed, Merck, CSL-Behring, Nufactor, Biomarin, Baxter and Catalyst as a consultant and/or speaker. Dr. Pasnoor has nothing to disclose. Dr. Statland has received personal compensation for activities with Sarepta, ATYR Bristol Meyers Squib, Acceleron,...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Hamasaki, A., Jawdat, O., Kimple, D., Dimachkie, M., Pasnoor, M., Statland, J., Barohn, R., Glenn, M., Herbelin, L. Tags: Myopathies & amp;amp; Myasthenia Gravis II Source Type: research
Performance test evaluation of intra-rater and inter-rater reliability among examiners of histopathological findings in myositis subtypes (P2.132)
Conclusions:This study explores intra and inter reliability for diagnosing DM, PM and NM by muscle biopsy specimens. If consistency can be shown in muscle biopsy interpretation by studying intra-rater and inter-rater reliability in fellows studying neuromuscular medicine, this will help to validate the use of muscle biopsy for diagnostic use in medical professionals with limited training.Disclosure: Dr. Kimple has nothing to disclose. Dr Barohn received personal compensation for activities with Grifols & Genzyme as a member of the Speakers Bureau and NuFactor as a consultant. Dr. Dimachkie has received personal compens...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kimple, D., Barohn, R., Dimachkie, M., Pasnoor, M., Glenn, M., Herbelin, L., Statland, J., Jawdat, O. Tags: Myopathies & amp;amp; Myasthenia Gravis II Source Type: research
Mitochondrial Skeletal and Cardiac Myopathy Responsive to Aggressive Immunosuppression in Rapidly Progressing Systemic Sclerosis (P5.077)
Conclusions:Perivascular epimysial inflammation is rarely seen in any disease. Mitochondrial myopathy without myositis has not been reported in systemic sclerosis. We propose that ischemia caused by vasculopathy and fibrosis in systemic sclerosis, together with subclinical mitochondrial pathology, severely affected skeletal and cardiac muscle due to their high metabolic demands. An unusual presentation of myopathy in autoimmune disease suggests an underlying latent pathology, such as mitochondrial myopathy. Rapidly progressing autoimmune disease necessitates aggressive immunosuppression.Disclosure: Dr. Yeo has nothing to d...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Yeo, C., Bunin, V., Jovan, P., Cykowski, M., Smith, R. Tags: Neuromuscular and Clinical Neurophysiology (EMG) ePoster Session Source Type: research
The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies
Anti-aminoacyl transfer RNA synthetase antibodies (anti-ARS) are a group of myositis-specific autoantibodies that are detected in the sera of patients with polymyositis and dermatomyositis (PM/DM) and also in those of patients with idiopathic interstitial pneumonias without any connective tissue disease (CTD), including PM/DM. Although we reported the clinical characteristics of interstitial lung disease with anti-ARS antibodies (ARS-ILD) with and without PM/DM, the long-term prognosis of ARS-ILD remains undetermined. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 15, 2017 Category: Respiratory Medicine Authors: Kiminobu Tanizawa, Tomohiro Handa, Ran Nakashima, Takeshi Kubo, Yuji Hosono, Kizuku Watanabe, Kensaku Aihara, Kohei Ikezoe, Akihiko Sokai, Yoshinari Nakatsuka, Yoshio Taguchi, Kazuhiro Hatta, Satoshi Noma, Yoichiro Kobashi, Akihiko Yoshizawa, Toru Oga, To Source Type: research
Inflammatory myopathy associated with myasthenia gravis with and without thymic pathology: Report of four cases and literature review
Discussion the recognition of these neuromuscular co-morbidities contributes to (i) understanding their pathogenic mechanisms, (ii) developing better management approaches and (iii) further improving disease outcomes. (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - April 14, 2017 Category: Allergy & Immunology Source Type: research
Toll-Like Receptor 4 –Myeloid Differentiation Primary Response Gene 88 Pathway Is Involved in the Inflammatory Development of Polymyositis by Mediating Interferon-γ and Interleukin-17A in Humans and Experimental Autoimmune Myositis Mouse Model
Hongya Zhang, Fangyuan He, Ming Shi, Wenxiu Wang, Xiaojia Tian, Juan Kang, Wenjuan Han, Rui Wu, Linfu Zhou, Mengmeng Hu, Xiaobo Li, Fang Mi, Gang Zhao, Hongge Jia (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - April 12, 2017 Category: Neurology Source Type: research
401 Cancer risk in clinically amyopathic dermatomyositis: A retrospective cohort study at four tertiary care centers
Clinically amyopathic dermatomyositis (CADM), characterized by pathognomonic cutaneous findings without muscle weakness, is an important subset and accounts for 20% of patients with dermatomyositis (DM). In patients with CADM, limited literature exists regarding the associated risk of malignancy as most studies have focused on classic DM or polymyositis. Therefore, we investigated the association between CADM and cancer at 4 tertiary care centers. Using the Partners Healthcare and New York University medical record systems, we reviewed the medical records of all patients with CADM treated between 2000 and 2016. (Source: Jo...
Source: Journal of Investigative Dermatology - April 12, 2017 Category: Dermatology Authors: J. Pinard, M. Roman, D. Kurtzman, A. Ho, A. Femia, R. Vleugels Tags: Clinical Research: Patient Outcomes Research Source Type: research
Overlapping features of polymyositis and inclusion body myositis in HIV-infected patients
Conclusions: HIV-positive patients with myositis may present with some characteristic polymyositis features including young age at onset, very high CK levels, or proximal weakness that improves with treatment. However, all HIV-positive patients with myositis eventually develop features most consistent with inclusion body myositis, including finger and wrist flexor weakness, rimmed vacuoles on biopsy, or anti-NT5C1A autoantibodies. (Source: Neurology)
Source: Neurology - April 10, 2017 Category: Neurology Authors: Lloyd, T. E., Pinal-Fernandez, I., Michelle, E. H., Christopher-Stine, L., Pak, K., Sacktor, N., Mammen, A. L. Tags: HIV, Muscle disease ARTICLE Source Type: research
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative
To develop response criteria for juvenile dermatomyositis (DM). We analysed the performance of 312 definitions that used core set measures from either the International Myositis Assessment and Clinical Studies Group (IMACS) or the Paediatric Rheumatology International Trials Organisation (PRINTO) and were derived from natural history data and a conjoint analysis survey. They were further validated using data from the PRINTO trial of prednisone alone compared to prednisone with methotrexate or cyclosporine and the Rituximab in Myositis (RIM) trial. At a consensus conference, experts considered 14 top candidate criteria base...
Source: Annals of the Rheumatic Diseases - April 6, 2017 Category: Rheumatology Authors: Rider, L. G., Aggarwal, R., Pistorio, A., Bayat, N., Erman, B., Feldman, B. M., Huber, A. M., Cimaz, R., Cuttica, R. J., de Oliveira, S. K., Lindsley, C. B., Pilkington, C. A., Punaro, M., Ravelli, A., Reed, A. M., Rouster-Stevens, K., van Royen-Kerkhof, Tags: Criteria Source Type: research
2016 American College of Rheumatology/European League Against Rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative
To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). Expert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in conjoint analysis surveys, where different levels of improvement in 2 core set measures were presented. The PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method determined the relative weights of core set measures and conjoint analysis definitions. The performance characteristics of the definitions were evaluated on p...
Source: Annals of the Rheumatic Diseases - April 6, 2017 Category: Rheumatology Authors: Aggarwal, R., Rider, L. G., Ruperto, N., Bayat, N., Erman, B., Feldman, B. M., Oddis, C. V., Amato, A. A., Chinoy, H., Cooper, R. G., Dastmalchi, M., Fiorentino, D., Isenberg, D., Katz, J. D., Mammen, A., de Visser, M., Ytterberg, S. R., Lundberg, I. E., Tags: Criteria Source Type: research
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative
ObjectiveTo develop response criteria for juvenile dermatomyositis (DM). MethodsWe analyzed the performance of 312 definitions that used core set measures from either the International Myositis Assessment and Clinical Studies Group (IMACS) or the Paediatric Rheumatology International Trials Organisation (PRINTO) and were derived from natural history data and a conjoint analysis survey. They were further validated using data from the PRINTO trial of prednisone alone compared to prednisone with methotrexate or cyclosporine and the Rituximab in Myositis (RIM) trial. At a consensus conference, experts considered 14 top candida...
Source: Arthritis and Rheumatism - April 6, 2017 Category: Rheumatology Authors: Lisa G. Rider, Rohit Aggarwal, Angela Pistorio, Nastaran Bayat, Brian Erman, Brian M. Feldman, Adam M. Huber, Rolando Cimaz, Rub én J. Cuttica, Sheila Knupp de Oliveira, Carol B. Lindsley, Clarissa A. Pilkington, Marilynn Punaro, Angelo Ravelli, Ann M. R Tags: Special Article Source Type: research
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative
ObjectiveTo develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). MethodsExpert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in conjoint analysis surveys, where different levels of improvement in 2 core set measures were presented. The PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method determined the relative weights of core set measures and conjoint analysis definitions. The performance characteristics of the definitions wer...
Source: Arthritis and Rheumatism - April 6, 2017 Category: Rheumatology Authors: Rohit Aggarwal, Lisa G. Rider, Nicolino Ruperto, Nastaran Bayat, Brian Erman, Brian M. Feldman, Chester V. Oddis, Anthony A. Amato, Hector Chinoy, Robert G. Cooper, Maryam Dastmalchi, David Fiorentino, David Isenberg, James D. Katz, Andrew Mammen, Mariann Tags: Special Article Source Type: research
Subclinical Cardiac Dysfunction in Polymyositis and Dermatomyositis: A Speckle-tracking Case-control Study.
CONCLUSION: Subclinical systolic impairment is common in patients with IIM without overt LV dysfunction. In this context, GLS is a potentially useful variable. PMID: 28365571 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 4, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research
High ‐resolution manometry in patients with idiopathic inflammatory myopathy: Elevated prevalence of esophageal involvement and differences according to autoantibody status and clinical subset
ConclusionsEsophageal involvement is common in myositis patients, but it correlates poorly with esophageal symptoms. Specific clinical and serologic groups have different manometric features. Muscle Nerve, 2017 (Source: Muscle and Nerve)
Source: Muscle and Nerve - April 4, 2017 Category: Internal Medicine Authors: Maria Casal ‐Dominguez, Iago Pinal‐Fernandez, Marianela Mego, Anna Accarino, Lluis Jubany, Fernando Azpiroz, Albert Selva‐O'callaghan Tags: Research Article Source Type: research
Immune ‐Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA–DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum
ConclusionThis is the largest, most comprehensive genetic association study to date in IBM. The data confirm that HLA is the most strongly associated region and identifies novel amino acid associations that may explain the risk in this locus. These amino acid associations differentiate IBM from polymyositis and dermatomyositis and may determine properties of the peptide‐binding groove, allowing it to preferentially bind autoantigenic peptides. A novel suggestive association within the chromosome 3 p21.31 region suggests a role for CCR5. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - April 4, 2017 Category: Rheumatology Authors: Simon Rothwell, Robert G. Cooper, Ingrid E. Lundberg, Peter K. Gregersen, Michael G. Hanna, Pedro M. Machado, Megan K. Herbert, Ger J. M. Pruijn, James B. Lilleker, Mark Roberts, John Bowes, Michael F. Seldin, Jiri Vencovsky, Katalin Danko, Vidya Limaye, Tags: Full Length Source Type: research
DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture.
Authors: Xie QB, Liang Y, Yang M, Yang Y, Cen XM, Yin G Abstract Abnormal immune response of the body against substances and tissues causes autoimmune diseases, such as polymyositis, dermatomyositis, and rheumatoid arthritis. Irregular lipid metabolism and inflammation may be a significant cause of autoimmune diseases. Although much progress has been made, mechanisms of initiation and proceeding of metabolic and inflammatory regulation in autoimmune disease have not been well-defined. And novel markers for the detection and therapy of autoimmune disease are urgent. mTOR signaling is a central regulator of extracell...
Source: Journal of Immunology Research - March 31, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Cardiac transplantation in dermatomyositis: A case report and literature review
Conclusions Severe cardiac involvement requiring transplantation is rare in dermatomyositis but does occur and appears to be related to a similar inflammatory process as noted in the skeletal muscle. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - March 31, 2017 Category: Pathology Source Type: research
[Polymyositis secondary to a non-Hodgkin's lymphoma].
PMID: 28345740 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - March 29, 2017 Category: Neurology Authors: Gil-Moreno MJ, Escolar E, Marasescu R, Camacho-Castaneda FI, Benito-Parra L Tags: Rev Neurol Source Type: research
A case of anti-aminoacyl tRNA synthetase (ARS) antibody-positive polymyositis (PM)/dermatomyositis (DM)-associated interstitial pneumonia (IP) successfully controlled with bosentan therapy
Publication date: Available online 29 March 2017 Source:Respiratory Medicine Case Reports Author(s): Tomoyuki Naito, Yosuke Tanaka, Mitsunori Hiron, Akihiko Gemma A 72-year-old woman was admitted to our hospital and was diagnosed with interstitial pneumonia (IP) associated with amyopathic dermatomyositis (ADM). The patient experienced three acute IP exacerbations in the 7 years that followed, which were each treated and resolved with steroid pulse therapy. The patient was closely examined for respiratory failure with right heart catheterization (RHC), which demonstrated that she had a mean pulmonary artery pressure (mPAP)...
Source: Respiratory Medicine Case Reports - March 29, 2017 Category: Respiratory Medicine Source Type: research
Red blood cell distribution width and neutrophil to lymphocyte ratio are correlated with disease activity of dermatomyositis and polymyositis
ConclusionBoth RDW and NLR are useful indices in assessing the disease activity of PM/DM. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - March 27, 2017 Category: Laboratory Medicine Authors: Ming ‐Zhu Gao, Yuan‐Lan Huang, Xiao‐Dan Wu, Qiang‐Wei Xu, Rong Ji, Bing Gu, Ai‐Yan Zhang, Ting‐Ting Hao, Zhi‐Jun Han, Tian‐Li Ren Tags: RESEARCH ARTICLE Source Type: research
Juvenile dermatomyositis/polymyositis and lymphoma
The objective of this literature review was to assess for any association between, and disease profile of, JDM/PM and lymphoma in childhood. Risk determinants of the possible development of lymphoma in the pediatric population with JDM/PM appear to be the degree and duration of inflammatory activity with chronic B-cell activation and/or antigen stimulation; a paraneoplastic relationship is unlikely. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - March 25, 2017 Category: Neurology Authors: Joerg-Patrick St übgen Tags: Review Article Source Type: research
Inflammatory Muscle Disease: A New Landscape
Publication date: Available online 22 March 2017 Source:Joint Bone Spine Author(s): Alain Meyer, Béatrice Lannes, Joëlle Goetz, Andoni Echaniz-Laguna, Dan Lipsker, Laurent Arnaud, Thierry Martin, Jacques Eric Gottenberg, Bernard Geny, Jean Sibilia Greater accuracy in clinical descriptions combined with advances in muscle histology and immunology have established that inflammatory muscle diseases (IMDs) resemble inflammatory joint diseases in that they constitute a highly heterogeneous group of conditions. The topographic distribution, severity, and tempo of onset vary widely, and the histological findings dist...
Source: Joint Bone Spine - March 23, 2017 Category: Orthopaedics Source Type: research
Relevance of clinical and autoantibody profiles in systemic sclerosis among Thais
ConclusionsATA and anti‐CENP were not helpful in differentiating the SSc subset in Thai SSc patients, albeit they were good for predicting hand function. Coexisting ATA and anti‐CENP negativity were associated with less extensive skin tightness and SSc overlap syndrome. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - March 9, 2017 Category: Rheumatology Authors: Chingching Foocharoen, Piyakarn Watcharenwong, Sittichai Netwijitpan, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Ratanavadee Nanagara Tags: Original Article Source Type: research
Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000-2012
Conclusions PLWHA had higher risks of incident Sjögren syndrome, psoriasis, SLE, autoimmune haemolytic anaemia and uveitis. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - March 9, 2017 Category: Rheumatology Authors: Yen, Y.-F., Chuang, P.-H., Jen, I.-A., Chen, M., Lan, Y.-C., Liu, Y.-L., Lee, Y., Chen, Y.-H., Chen, Y.-M. A. Tags: Immunology (including allergy), Muscle disease, Ophthalmology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Systemic lupus erythematosus Clinical and epidemiological research Source Type: research
Thigh muscle MRI in immune-mediated necrotising myopathy: extensive oedema, early muscle damage and role of anti-SRP autoantibodies as a marker of severity
Objectives The aims of this study were to define the pattern of muscle involvement in patients with immune-mediated necrotising myopathy (IMNM) relative to those with other inflammatory myopathies and to compare patients with IMNM with different autoantibodies. Methods All Johns Hopkins Myositis Longitudinal Cohort subjects with a thigh MRI (tMRI) who fulfilled criteria for IMNM, dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) or clinically amyopathic DM (CADM) were included in the study. Muscles were assessed for intramuscular and fascial oedema, atrophy and fatty replacement. Disease subgroups wer...
Source: Annals of the Rheumatic Diseases - March 9, 2017 Category: Rheumatology Authors: Pinal-Fernandez, I., Casal-Dominguez, M., Carrino, J. A., Lahouti, A. H., Basharat, P., Albayda, J., Paik, J. J., Ahlawat, S., Danoff, S. K., Lloyd, T. E., Mammen, A. L., Christopher-Stine, L. Tags: Immunology (including allergy), Muscle disease, Connective tissue disease, Musculoskeletal syndromes Clinical and epidemiological research Source Type: research
Neurological manifestations in dogs naturally infected by Leishmania infantum: descriptions of 10 cases and a review of the literature
This study confirms that both central and peripheral nervous systems can be affected by leishmaniasis and provides an overview on the possible etiopathogenetic mechanisms. In addition, clinical and diagnostic findings, therapy and follow‐up of affected dogs are described. (Source: The Journal of Small Animal Practice)
Source: The Journal of Small Animal Practice - March 6, 2017 Category: Veterinary Research Authors: A. P. Giannuzzi, M. Ricciardi, A. De Simone, F. Gernone Tags: REVIEW Source Type: research
The clinical and pathological characteristics of nephropathies in connective tissue diseases in the Japan Renal Biopsy Registry (J-RBR)
ConclusionsUsing the J-RBR database, our study revealed that biopsy-confirmed cases of connective tissue diseases such as RA, SjS, scleroderma, and MCTD show various clinical and pathological characteristics, depending on the underlying diseases and the medication used. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 1, 2017 Category: Urology & Nephrology Source Type: research
Increased risk of comorbid rheumatic disorders in vitiligo patients: A nationwide population ‐based study
Abstract Vitiligo is a common acquired depigmentation disorder. Previous studies have shown that vitiligo is associated with a variety of autoimmune disorders. However, a large‐scale epidemiological study focused on comorbid rheumatic disorders has not been undertaken. To clarify the associations between vitiligo and various rheumatic disorders, we performed a cross‐sectional study using data from the Korean National Health Insurance claims database. Between 2009 and 2013, totals of 86 210 patients with vitiligo and 172 420 age‐ and sex‐matched controls without vitiligo were enrolled in this study. Vitiligo patient...
Source: The Journal of Dermatology - March 1, 2017 Category: Dermatology Authors: Chong Won Choi, Sung Hye Eun, Kwang Hyun Choi, Jung Min Bae Tags: Original Article Source Type: research
Successful treatment of a refractory dysbiotic intestinal pseudo-obstruction in a patient with systemic sclerosis-polymyositis overlap syndrome by intravenous immunoglobulin administration possibly related to gut flora normalisation.
Authors: Kamei R, Yamaoka T, Ikinaga K, Murota H, Shimizu K, Katayama I Abstract ****************************************************************************. PMID: 28229828 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 25, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Effective Use of Calcineurin Inhibitor in Combination Therapy for Interstitial Lung Disease in Patients With Dermatomyositis and Polymyositis
Objective: The current study demonstrated the potential use of calcineurin inhibitor (CNI) in combination therapy for interstitial lung disease (ILD) complicated with dermatomyositis (DM) and polymyositis (PM). Methods: Thirty DM/PM patients with ILD were enrolled in this study. Continuous intravenous administration of cyclosporine A (IV-CsA) was simultaneously started with corticosteroid in patients presenting more than two respiratory distress factors as follows: (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - February 23, 2017 Category: Rheumatology Tags: Original Articles Source Type: research
Effects of exercise therapy on polymyositis complicated by post-myocarditis cardiomyopathy: A case report.
CONCLUSION: With appropriate care to avoid exacerbation of heart failure and myositis, staged increases in the volume of supervised and unsupervised exercise therapy can safely and effectively maintain and improve physical capacity, exercise tolerance, and overall physical activity. PMID: 28218333 [PubMed - as supplied by publisher] (Source: Journal of Rehabilitation Medicine)
Source: Journal of Rehabilitation Medicine - February 23, 2017 Category: Rehabilitation Tags: J Rehabil Med Source Type: research