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The Effect of Non-invasive Respiratory Support on Outcome and Its Risks in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2)-Related Hypoxemic Respiratory Failure
Conditions: COVID-19; Hypoxemic Respiratory Failure Intervention: Device: High flow nasal oxygen (HFNO, more than 15 L/min) Sponsor: Amsterdam UMC, location VUmc Active, not recruiting
Source: ClinicalTrials.gov - September 13, 2023 Category: Research Source Type: clinical trials
COVID-19-related secretory otitis media in the omicron era: a case series
ConclusionSARS-CoV-2 RNA can be detected in MEE caused by coronavirus disease 2019-related secretory otitis media even when a patient ’s nasopharyngeal secretion tests PCR-negative for SARS-CoV-2. The virus can remain in the MEE for a long time after SARS-CoV-2 infection.
Source: European Archives of Oto-Rhino-Laryngology - September 13, 2023 Category: ENT & OMF Source Type: research
Cardiovascular Disease and COVID-19 Vaccines: A Systematic Review and Analysis of Published Cases
Coronaviruses are a group of viruses that cause mild to moderate upper respiratory tract disease in humans. In late 2019, a new strain, severe acute respiratory syndrome coronavirus (SARS-CoV-2), caused COVID-19.1,2 By the end of 2022, COVID-19 has been the reason for over 6.6 million deaths and over 600 million infections.3
The most commonly reported symptoms of the infection ...
Source: Radcliffe Cardiology - September 13, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Africa: How Evasive and Transmissible Is the Newest Omicron Offshoot, BA.2.86, That Causes Covid-19? 4 Questions Answered
[The Conversation Africa] The latest variant, or sublineage, of SARS-CoV-2 to emerge on the scene, BA.2.86, has public health experts on alert as COVID-19 hospitalizations begin to rise and the new variant makes its way across the globe.
Source: AllAfrica News: Health and Medicine - September 13, 2023 Category: African Health Tags: Africa Coronavirus Health and Medicine Source Type: news
Africa: CDC Greenlights Two Updated Covid-19 Vaccines, but How Will They Fare Against the Latest Variants? 5 Questions Answered
[The Conversation Africa] On Sept. 12, 2023, the Centers for Disease Control and Prevention recommended the newly formulated COVID-19 vaccines for all Americans ages 6 months and up, hours after its expert advisory committee voted 13 to 1 in favor of recommending the vaccines.
Source: AllAfrica News: Health and Medicine - September 13, 2023 Category: African Health Tags: Africa Coronavirus Health and Medicine Source Type: news
Covid is here to stay. How will we know when it stops being special?
For some people, covid will always be high risk. Others wonder when — or if — we can stop treating the coronavirus differently from other common viruses.
Source: Washington Post: To Your Health - September 13, 2023 Category: Consumer Health News Authors: Carolyn Y. Johnson Source Type: news
Changing Molecular Profiles of Human Cryptosporidiosis Cases in Scotland as a Result of the Coronavirus Disease, COVID-19 Pandemic
This report assessed the impact of the pandemic on Scottish cryptosporidiosis cases, and identified changes in circulating molecular variants of Cryptosporidium species. Molecular data generated using real time PCR and GP60 nested-PCR assays on laboratory-confirmed cryptosporidiosis cases reported during 2018-22 were analysed. The Scottish Microbiology Reference Laboratories (SMiRL), Glasgow, received 774 Cryptosporidium-positive faeces during 2018-22, of which 486 samples were successfully subtyped. During this time period, C. hominis (n = 155; 21%) and C. parvum (n = 572; 77%) were the most commonly detected species. The...
Source: British Journal of Biomedical Science - September 13, 2023 Category: Laboratory Medicine Authors: Ross Bacchetti Lisa Connelly Lynda Browning Claire L Alexander Source Type: research
Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice
Commun Biol. 2023 Sep 13;6(1):935. doi: 10.1038/s42003-023-05263-6.ABSTRACTA recently emerged sub-lineage of Omicron, BA.5, together with BA.4, caused a fifth wave of coronavirus disease (COVID-19) in South Africa and subsequently emerged as a predominant strain globally due to its high transmissibility. The lethality of BA.5 infection has not been studied in an acute hACE2 transgenic (hACE2.Tg) mouse model. Here, we investigated tissue-tropism and immuno-pathology induced by BA.5 infection in hACE2.Tg mice. Our data show that intranasal infection of BA.5 in hACE2.Tg mice resulted in attenuated pulmonary infection and path...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Zaigham Abbas Rizvi Jyotsna Dandotiya Srikanth Sadhu Ritika Khatri Janmejay Singh Virendra Singh Neeta Adhikari Kritika Sharma Vinayake Das Amit Kumar Pandey Bhabatosh Das Guruprasad Medigeshi Shalendra Mani Shinjini Bhatnagar Sweety Samal Anil Kumar Pand Source Type: research
Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
Virus Res. 2023 Sep 11:199221. doi: 10.1016/j.virusres.2023.199221. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic is fading, however its etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues posing - despite the availability of licensed vaccines - a global health threat, due to the potential emergence of vaccine-resistant SARS-CoV-2 variants. This makes the development of new drugs against COVID-19 a persistent urgency and sets as research priority the validation of novel therapeutic targets within the SARS-CoV-2 proteome. Among these, a promising one is the...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Irene Boniardi Angela Corona Jerome Basquin Claire Basquin Jessica Milia Istv án Nagy Enzo Tramontano Luca Zinzula Source Type: research
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation
Curr Opin Immunol. 2023 Sep 11;84:102387. doi: 10.1016/j.coi.2023.102387. Online ahead of print.ABSTRACTCOVID-19 is an infectious and inflammatory disease caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2) that might progress to severe illness in humans, characterized by excessive pulmonary and systemic inflammation. Exacerbated production of inflammatory cytokines and cell death contributes to disease aggravation and the inflammasomes take a central stage in this process. Activation of the NLRP3 has been demonstrated in macrophages and monocytes infected in vitro, in mouse models of infection, and in c...
Source: Current Opinion in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Tamara S Rodrigues Dario S Zamboni Source Type: research
Impact of the early months of the COVID-19 pandemic on the sleep patterns of a Brazilian population sample
Chronobiol Int. 2023 Sep 12:1-13. doi: 10.1080/07420528.2023.2255667. Online ahead of print.ABSTRACTHumanitarian and health crisis have drastic effects on the physical and mental well-being of people. The COVID-19 pandemic forced many countries to impose containment measures on its population to halt the spread of the new coronavirus (SARS-CoV-2). This aim of this study was to explore self-reported sleep quality and insomnia symptoms in a sample of the Brazilian population before and during the COVID-19 quarantine period. Our data was collected through online questionnaires, including the Pittsburgh Sleep Quality Index, th...
Source: Chronobiology International - September 13, 2023 Category: Biology Authors: Sergio Brasil Tufik Gabriel Natan Pires Allan Saj Porcacchia Andr éia Gomes Bezerra Monica Levy Andersen Sergio Tufik Source Type: research
Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
Virus Res. 2023 Sep 11:199221. doi: 10.1016/j.virusres.2023.199221. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic is fading, however its etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues posing - despite the availability of licensed vaccines - a global health threat, due to the potential emergence of vaccine-resistant SARS-CoV-2 variants. This makes the development of new drugs against COVID-19 a persistent urgency and sets as research priority the validation of novel therapeutic targets within the SARS-CoV-2 proteome. Among these, a promising one is the...
Source: Virus Research - September 13, 2023 Category: Virology Authors: Irene Boniardi Angela Corona Jerome Basquin Claire Basquin Jessica Milia Istv án Nagy Enzo Tramontano Luca Zinzula Source Type: research
Over but not gone: lingering epigenetic effects of COVID-19
Trends Immunol. 2023 Sep 11:S1471-4906(23)00180-1. doi: 10.1016/j.it.2023.08.012. Online ahead of print.ABSTRACT'Long COVID' affects nearly one in five adults who have had coronavirus disease 2019 (COVID-19), yet the mechanisms underlying this disorder remain poorly understood. In a new study, Cheong et al. show that the epigenetic and transcriptional state of myeloid immune cells and their progenitors are durably altered in patients following severe COVID-19.PMID:37704548 | DOI:10.1016/j.it.2023.08.012
Source: Trends in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Brandon T Tran Ruoqiong Cao Katherine Y King Source Type: research
