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Case Report: Spectrum of interesting ocular manifestations following COVID-19 vaccination: a case series of real-world presentations
Conclusions and importanceVisual symptoms and various ocular adverse events can occur following COVID-19 vaccination, which warrants further investigation and urgent intervention if necessary. We would suggest patients receiving the COVID-19 vaccination be aware of possible ocular complications and report any symptoms, regardless of severity.
Source: Frontiers in cellular and infection microbiology - September 15, 2023 Category: Microbiology Source Type: research

With the Decongestant SNAFU, the FDA Tries Something New
It’s easy to understand how a medicine like phenylephrine got onto pharmacy shelves in the first place. The common decongestant, used most often as an ingredient in multidrug cold medications like DayQuil and Sudafed PE, was initially designated as “safe and effective” by the Food and Drug Administration (FDA) in 1976, when the agency was newly—and less stringently than today—greenlighting drugs that had been on the market for years before the agency had established any efficacy standards. After a full review of 14 studies (12 unpublished and two published) from pharmaceutical companies—...
Source: TIME: Health - September 14, 2023 Category: Consumer Health News Authors: Haley Weiss Tags: Uncategorized healthscienceclimate Source Type: news

There ’ s No Sign of Widespread COVID-19 Mandates. Republicans Are Warning of Them Anyway
As Americans fend off a late summer COVID-19 spike and prepare for a fresh vaccine rollout, Republicans are raising familiar fears that government-issued lockdowns and mask mandates are next. [time-brightcove not-tgx=”true”] It’s been a favorite topic among some of the GOP’s top presidential contenders. Florida Gov. Ron DeSantis told reporters that people are “lurching toward” COVID-19 restrictions and “there needs to be pushback.” South Carolina Sen. Tim Scott posted online that the “radical Left” seeks to bring back school closures a...
Source: TIME: Health - September 14, 2023 Category: Consumer Health News Authors: ALI SWENSON / AP Tags: Uncategorized COVID-19 wire Source Type: news

Signaling pathways in macrophages: molecular mechanisms and therapeutic targets
MedComm (2020). 2023 Sep 11;4(5):e349. doi: 10.1002/mco2.349. eCollection 2023 Oct.ABSTRACTMacrophages play diverse roles in development, homeostasis, and immunity. Accordingly, the dysfunction of macrophages is involved in the occurrence and progression of various diseases, such as coronavirus disease 2019 and atherosclerosis. The protective or pathogenic effect that macrophages exert in different conditions largely depends on their functional plasticity, which is regulated via signal transduction such as Janus kinase-signal transducer and activator of transcription, Wnt and Notch pathways, stimulated by environmental cue...
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Ming Li Mengjie Wang Yuanjia Wen Hongfei Zhang Guang-Nian Zhao Qinglei Gao Source Type: research

Fortifying immunity: PLSCR1 picks battle against SARS-CoV-2
Cell Host Microbe. 2023 Sep 13;31(9):1417-1419. doi: 10.1016/j.chom.2023.08.014.ABSTRACTInterferons (IFNs) and interferon-stimulated genes (ISGs) are the major players in the host innate immunity against viral infection. In a recent Nature paper, Xu et al. identified phospholipid scramblase 1 (PLSCR1) as a novel ISG that restricts severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by blocking virus-cell fusion.PMID:37708846 | DOI:10.1016/j.chom.2023.08.014
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Minghua Li Source Type: research

Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventions
In this study, we focus on the IPF and COVID-19 pathogenesis and the potential role of Apigenin in addressing disease progression.PMID:37707699 | DOI:10.1007/s11010-023-04845-6
Source: Molecular and Cellular Biochemistry - September 14, 2023 Category: Biochemistry Authors: Pritha Saha Priti Talwar Source Type: research

Overreactive macrophages in SARS-CoV-2 infection: The effects of ACEI
Int Immunopharmacol. 2023 Sep 12;124(Pt A):110858. doi: 10.1016/j.intimp.2023.110858. Online ahead of print.ABSTRACTAmong various factors influencing the course of SARS-CoV-2 infection in humans, macrophage overactivation is considered the main cause of the cytokine storm that leads to severe complications of COVID-19. Moreover, the increased expression of angiotensin converting enzyme 2 (ACE2), an obligatory entry receptor of the coronavirus, caused by treatment with ACE inhibitors (ACEI) lowered overall confidence in the safety of these drugs. However, analysis of the course of coronavirus infection in patients treated w...
Source: International Immunopharmacology - September 14, 2023 Category: Allergy & Immunology Authors: Dominik Felkle Katarzyna Zi ęba Konrad Kaleta Julia Czaja Amanda Zyzdorf Wiktoria Soboci ńska Mateusz Jarczy ński Krzysztof Bryniarski Katarzyna Nazimek Source Type: research

Nucleic Acid Detection through RNA-Guided Protease Activity in Type III-E CRISPR-Cas Systems
Chembiochem. 2023 Sep 14:e202300401. doi: 10.1002/cbic.202300401. Online ahead of print.ABSTRACTRNA-guided protease activity was recently discovered in the type III-E CRISPR-Cas systems (Craspase), providing a novel platform for engineering a protein probe instead of the commonly used nucleic acid probe in the nucleic acid detection assays. Here, by adapting a fluorescence readout technique using the affinity- and fluorescent protein dual-tagged Csx30 protein substrate, we established an assay monitoring Csx30 cleavage by target ssRNA-activated Craspase. Four Craspase-based nucleic acid detection systems for genes from sev...
Source: Chembiochem - September 14, 2023 Category: Biochemistry Authors: Qiuqiu He Xinlong Lei Yuanjun Liu Xiaoshen Wang Nan Ji Hang Yin Huiping Wang Heng Zhang Guimei Yu Source Type: research

An Analysis of Infection Prevention and Control Practices in Designated Hospitals that Treat COVID-19: A Systematic Review and Meta-Analysis
CONCLUSION: Chinese prophylaxis and controlling measures for COVID-19 are mainly to protect vulnerable populations, cut off transmission routes, and control the source of infection. Therefore, we must also do our best to prevent and control novel coronavirus pneumonia to protect our health and reduce the burden on our country.PMID:37708537
Source: Alternative Therapies in Health and Medicine - September 14, 2023 Category: Complementary Medicine Authors: Yi Zhu Xia Zhao Ying Guo Wei Li Yingying Pan Jianwen Zhuang Jun Zhou Yurong Huang Source Type: research

Vaccination coverage survey of children aged 1-3 years in Beijing, China, 2005-2021
CONCLUSION: The coverage level and service quality of routine immunization in Beijing were relatively high. However, as influenced by COVID-19 epidemics, both on-time and in-time vaccination rates decreased significantly, except for BCG and HepB. Under the background of COVID-19 pandemic, the keys to maintain high level of vaccination coverage include flexible immunization service time to ensure the guardians bringing their children for vaccination timely, and more attention from providers to the doses after children's first birthday.PMID:37709591 | DOI:10.1016/j.vaccine.2023.08.015
Source: Vaccine - September 14, 2023 Category: Allergy & Immunology Authors: Wen-Yan Ji Dong-Lei Liu Rui Yu Liang Miao Qian-Li Yuan Luo-Dan Suo Jian-Ping Yu Source Type: research

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