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We would like to express our gratitude to Chen and Yong1 for their interest in our article entitled “Human genetics influence microbiome composition involved in asthma exacerbations despite inhaled corticosteroid treatment”.2 We read with enthusiasm their suggestions to increase the robustness of the genetic associations with microbiome composition that we reported in individuals from the Geno mics and Metagenomics of Asthma Severity (GEMAS) study.3
Source: Journal of Allergy and Clinical Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Javier Perez-Garcia, Maria Pino-Yanes, Fabian Lorenzo-Diaz Tags: Correspondence Source Type: research
Inhaled corticosteroid treatment's impact on asthma exacerbations: Influence of human genetics on microbiome composition
We read with great interest the study by Perez-Garcia et al1 on the human genetics that influence microbiome composition involved in asthma exacerbations despite inhaled corticosteroid (ICS) treatment. In this retrospective cohort study using data from the Genomic and Metagenomics of Asthma Severity (GEMAS) study, Perez-Garcia et al1 hypothesized a rel ationship between the genetic variants, microbiome associated with asthma exacerbation, and possible biologic pathway. To augment their findings, we would like to offer several suggestions on covariates that could be adopted and included in their study.
Source: Journal of Allergy and Clinical Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Yu-Jen Chen, Su-Boon Yong Tags: Correspondence Source Type: research
The SARS-CoV-2 Pandemic and Asthma: What We Have Learned and What is still Unknown
The SARS-CoV-2 pandemic has brought new insights into the immunological intricacies of asthma. In this review, we discuss the epidemiology of asthma in patients infected with SARS-CoV-2 and the risk of severe infection. Type 2 inflammation had an overall protective effect against SARS-CoV-2 infection by various mechanisms summarized in this review. Asthma, intranasal, and inhaled corticosteroids decreased the ACE2 receptor, an important receptor for SARS-CoV-2 entry into host cells. We summarize the nuances of treatment of type 2 inflammation despite its underlying protective effects.
Source: Journal of Allergy and Clinical Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Christa McPhee, Kateryna Yevdokimova, Linda Rogers, Monica Kraft Source Type: research
Management of Mechanical Nasal Obstruction Isolated or Associated to Upper Airway Inflammatory Diseases in Real Life: Use of both Subjective and Objective Criteria
AbstractPurpose of ReviewMechanical nasal obstruction (MNO) is a prevalent condition with a high impact on patient ’s quality-of-life (QoL) and socio-economic burden. The aim of this study was to determine the usefulness of both subjective and objective criteria in the appropriate management of MNO, either alone or associated to upper airway inflammatory diseases such as allergic rhinitis (AR) or chronic rhino sinusitis with nasal polyps (CRSwNP).Recent FindingsA long debate persists about the usefulness of subjective and objective methods for making decisions on the management of patients with nasal obstruction. Establi...
Source: Current Allergy and Asthma Reports - September 19, 2023 Category: Allergy & Immunology Source Type: research
A cost ‐effective alternative for nasal corticosteroid saline irrigations
Source: International Forum of Allergy and Rhinology - September 17, 2023 Category: Allergy & Immunology Authors: Do Yeon Cho,
Jessica W. Grayson,
Bradford A. Woodworth Tags: LETTER TO THE EDITOR Source Type: research
Benralizumab Allows Inhaled Corticosteroid Taper for Asthma Patients
(MedPage Today) -- MILAN -- Benralizumab (Fasenra) allowed patients with severe eosinophilic asthma to reduce inhaled corticosteroid (ISC) use without compromising control, the SHAMAL phase IV randomized trial found.
After 32 weeks, 92% of patients...
Source: MedPage Today Allergy - September 14, 2023 Category: Allergy & Immunology Source Type: news
Managing Anaphylaxis - Epinephrine, Antihistamines, and Corticosteroids: Over 10 years of C-CARE Registry Data
CONCLUSION: Our findings in this predominantly pediatric population support the early use of epinephrine and suggest a beneficial effect of antihistamines. Corticosteroids use in anaphylaxis should be revisited.PMID:37689113 | DOI:10.1016/j.anai.2023.08.606
Source: Annals of Allergy, Asthma and Immunology - September 9, 2023 Category: Allergy & Immunology Authors: Luca Delli Colli Adnan Al Ali Sofianne Gabrielli Marina Delli Colli Pasquale Mule Benjamin Lawson Ann E Clarke Judy Morris Jocelyn Gravel Rod Lim Edmond S Chan Ran D Goldman Andrew O'Keefe Jennifer Gerdts Derek K Chu Julia Upton Elana Hochstadter Adam Bre Source Type: research
Severe asthma trajectories in adults: findings from the NORDSTAR cohort
Conclusions
Four distinct trajectories of severe asthma were identified illustrating different patterns of progression of asthma severity. This may eventually enable the development of better preventive management strategies in severe asthma.
Source: European Respiratory Journal - September 9, 2023 Category: Respiratory Medicine Authors: von Bülow, A., Hansen, S., Sandin, P., Ernstsson, O., Janson, C., Lehtimäki, L., Kankaanranta, H., Ulrik, C., Aarli, B. B., Geale, K., Tang, S. T., Wolf, M., Backer, V., Hilberg, O., Altraja, A., Backman, H., Ludviksdottir, D., Bjö Tags: Asthma and allergy Original Articles: Asthma and natural history Source Type: research
Meta-Analysis Points to Most Effective Topical Treatments for Atopic Dermatitis
(MedPage Today) -- Pimecrolimus, tacrolimus, and moderate-potency topical corticosteroids (TCS) are the most effective in the treatment of atopic dermatitis (AD), according to a systematic review and meta-analysis.
High-certainty evidence showed...
Source: MedPage Today Allergy - September 8, 2023 Category: Allergy & Immunology Source Type: news
Immediate hypersensitivity to parenteral corticosteroids caused by IgE-mediated allergy to carmellose
J Investig Allergol Clin Immunol. 2023 Sep 6:0. doi: 10.18176/jiaci.0938. Online ahead of print.NO ABSTRACTPMID:37675798 | DOI:10.18176/jiaci.0938
Source: Journal of Investigational Allergology and Clinical Immunology - September 7, 2023 Category: Allergy & Immunology Authors: C Gal án A Arrien de Lecea B Bartolom é Zavala M P érez Escalera J S ánchez de Vicente Source Type: research
