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Updates in the diagnosis and practical management of allergic rhinitis
Expert Rev Clin Pharmacol. 2023 Jun 16:1-8. doi: 10.1080/17512433.2023.2225770. Online ahead of print.ABSTRACTINTRODUCTION: Allergic rhinitis (AR) is a widespread disease that can be associated with other conditions, including conjunctivitis, rhinosinusitis, asthma, food allergy, and atopic dermatitis. Diagnosis is based on the history and documentation of sensitization, such as the production of allergen-specific IgE, preferably using molecular diagnostics. Treatments are based on patient education, non-pharmacological and pharmacological remedies, allergen-specific immunotherapy (AIT), and surgery. Symptomatic treatments...
Source: Expert Review of Clinical Pharmacology - June 14, 2023 Category: Drugs & Pharmacology Authors: Chiara Trincianti Maria Angela Tosca Giorgio Ciprandi Source Type: research
Controller therapy attenuates asthma exacerbations associated with prior SARS-CoV-2 infection in children
Abbreviations: Coronavirus disease 2019 (COVID-19); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), inhaled corticosteroids (ICS), oral corticosteroid (OCS), short-acting beta-agonist (SABA), long-acting beta-agonist (LABA), leukotriene receptor antagonist (LTRA), rate ratios (RR), polymerase chain reaction (PCR)
Source: Annals of Allergy, Asthma and Immunology - June 12, 2023 Category: Allergy & Immunology Authors: Iris Kim, Tricia Morphew, Christine Chou, Louis Ehwerhemuepha, Stanley Galant Tags: Letters Source Type: research
Blood transcriptomic signature in type-2 biomarker-low severe asthma and asthma control
Patients with type-2 (T2) cytokine-low severe asthma often have persistent symptoms despite suppression of T2 inflammation with corticosteroids.
Source: Journal of Allergy and Clinical Immunology - June 11, 2023 Category: Allergy & Immunology Authors: Xue Zeng, Jing Qing, Chi-Ming Li, Jiamiao Lu, Tracy Yamawaki, Yi-Hsiang Hsu, Bryan Vander Lugt, Hailing Hsu, John Busby, P.J. McDowell, David J. Jackson, Ratko Djukanovic, John G. Matthews, Joseph R. Arron, Peter Bradding, Christopher E. Brightling, Rekha Source Type: research
Blood transcriptomic signature in type-2 biomarker low severe asthma and asthma control
Patients with Type-2 (T2) cytokine-low severe asthma often have persistent symptoms despite suppression of T2-inflammation with corticosteroids (CS).
Source: Journal of Allergy and Clinical Immunology - June 11, 2023 Category: Allergy & Immunology Authors: Xue Zeng, Jing Qing, Chi-Ming Li, Jiamiao Lu, Tracy Yamawaki, Yi-Hsiang Hsu, Bryan Vander Lugt, Hailing Hsu, John Busby, P.J. McDowell, David J. Jackson, Ratko Djukanovic, John G. Matthews, Joseph R. Arron, Peter Bradding, Christopher E. Brightling, Rekha Source Type: research
Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment
Source: Journal of Allergy and Clinical Immunology - June 8, 2023 Category: Allergy & Immunology Authors: Javier Perez-Garcia, Antonio Espuela-Ortiz, Jos é M. Hernández-Pérez, Ruperto González-Pérez, Paloma Poza-Guedes, Elena Martin-Gonzalez, Celeste Eng, Olaia Sardón-Prado, Elena Mederos-Luis, Paula Corcuera-Elosegui, Inmaculada Sánchez-Machín, Javie Source Type: research
Stepping up our game with secondary immune deficiency
Pharmacologic immune suppression in the past was dirty. I imagine many readers of this journal remember days when systemic corticosteroids were pretty much the only medication they had to effectively treat asthma and rheumatologic diseases. Fortunately, as the management of inflammatory and autoimmune conditions has been refined over the past few decades, our reliance on broad immune suppressants has decreased. Although we still have our “old faithful” prednisone to fall back on, we can now use more targeted therapies to improve outcomes.
Source: Annals of Allergy, Asthma and Immunology - June 1, 2023 Category: Allergy & Immunology Authors: Jay A. Lieberman Tags: Editorial Source Type: research
Estimating Inhaled Corticosteroid Exposure from Short-Acting β2-Agonist–Inhaled Corticosteroid Rescue
Source: Journal of Asthma and Allergy - May 31, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Diagnosis and Management of Pediatric Chronic Hand Eczema: The PeDRA CACHES Survey
CONCLUSIONS: This is the first characterization of P-CHE among pediatric dermatologists in the United States and Canada. This assessment may prove useful in designing further investigations including prospective studies of P-CHE epidemiology, morphology, nomenclature, and management.PMID:37225932 | DOI:10.1007/s40272-023-00574-x
Source: Paediatric Drugs - May 24, 2023 Category: Pediatrics Authors: Michael A Haft Helen H Park Stephanie S Lee Jessica M Sprague Amy S Paller Colleen H Cotton Jacob P Thyssen Lawrence F Eichenfield Source Type: research
Knowledge Gaps in the Diagnosis and Management of Anaphylaxis
Ann Allergy Asthma Immunol. 2023 May 18:S1081-1206(23)00336-8. doi: 10.1016/j.anai.2023.05.010. Online ahead of print.ABSTRACTKnowledge gaps in the diagnosis and treatment of anaphylaxis impede the clinician's ability to effectively manage patients with anaphylaxis. This review will emphasize the lack of a global consensus on defining and determining the severity of anaphylaxis; the need for validating biomarkers used for diagnosing anaphylaxis; and data collection deficiencies. Perioperative anaphylaxis has a wide differential diagnosis, often requires treatment beyond epinephrine, and poses a challenge for the clinician ...
Source: Annals of Allergy, Asthma and Immunology - May 20, 2023 Category: Allergy & Immunology Authors: Dana V Wallace Source Type: research
Allergic Rhinitis: Rapid Evidence Review
Am Fam Physician. 2023 May;107(5):466-473.ABSTRACTAllergic rhinitis, the fifth most common chronic disease in the United States, is an immunoglobulin E-mediated process. A family history of allergic rhinitis, asthma, or atopic dermatitis increases a patient's risk of being diagnosed with allergic rhinitis. People in the United States are commonly sensitized to grass, dust mites, and ragweed allergens. Dust mite-proof mattress covers do not prevent allergic rhinitis in children two years and younger. Diagnosis is clinical and based on history, physical examination, and at least one symptom of nasal congestion, runny or itch...
Source: American Family Physician - May 16, 2023 Category: Primary Care Authors: Jackie Weaver-Agostoni Zachary Kosak Stacy Bartlett Source Type: research
