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Clinical Characteristics and Economic Burden of Asthma in China: A Multicenter Retrospective Study
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):290-298. doi: 10.18502/ijaai.v22i3.13057.ABSTRACTAsthma is a common chronic airway inflammation that produces a healthcare burden on the economy. We aim to obtain a better understanding of the clinical status and disease burden of patients with asthma in China. A retrospective study was carried out based on the computerized medical records in the Jinan Health Medical Big Data Platform between 2011 and 2019 (available data from 38 hospitals). The asthma severity of each patient was assessed retrospectively and categorized as mild, moderate, or severe according to Global Initi...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Bin Shang Xiangguo Li Yu Xu Wenxin Ren Junren Wang Chunyan Xing Shujuan Jiang Jian Sun Source Type: research

Evidence-based use of antihistamines for treatment of allergic conditions
Ann Allergy Asthma Immunol. 2023 Jul 28:S1081-1206(23)00524-0. doi: 10.1016/j.anai.2023.07.019. Online ahead of print.ABSTRACTAvailable since the 1940s, H1-antihistamines are mainstay treatments for allergic conditions such as allergic rhinitis and urticaria. They function as inverse agonists that bind to the H1 receptor to inhibit histamine-induced inflammation. The older, first-generation drugs are no longer recommended for patient use due to their well documented negative side effect profile. Evidence has been accumulating to support a newer generation of H1-antihistamines in oral and intranasal formulations, including ...
Source: Annals of Allergy, Asthma and Immunology - July 30, 2023 Category: Allergy & Immunology Authors: Sophia Linton Lubnaa Hossenbaccus Anne K Ellis Source Type: research

Incidence of hypocortisolism with long ‐term budesonide irrigation for chronic rhinosinusitis
ConclusionProlonged use of BI alone is not likely to cause hypocortisolemia in the majority of patients. However, concomitant use of inhaled and oral steroids and male sex may be associated with hypocortisolemia. Surveillance of cortisol levels may be considered in vulnerable populations who use BI regularly, particularly in patients using other forms of corticosteroids with known systemic absorption.
Source: International Forum of Allergy and Rhinology - July 24, 2023 Category: Allergy & Immunology Authors: Bruna R. C. Silva, Matthew A. Tyler, Yifei Ma, Jane Wang, Jayakar V. Nayak, Zara M. Patel, Peter H. Hwang Tags: ORIGINAL ARTICLE Source Type: research

Intramuscular corticosteroid injections should be an option under the policy level recommendation in the international consensus statement on allergic rhinitis
Source: International Forum of Allergy and Rhinology - July 22, 2023 Category: Allergy & Immunology Authors: Jacob Alexander Ru, Ahmed Bayoumy Bayoumy Tags: LETTER TO THE EDITOR Source Type: research

The Effect of Corticosteroids on Sinus Microbiota in Chronic Rhinosinusitis Patients with Nasal Polyposis
CONCLUSION: In this pilot study, both treatment options were effective to improve symptoms in the short-term but not in the long-term, and were not linked to any clear sinus microbiota response. As a result, this study supports the avoidance of systemic antibiotics without evidence of active infection.PMID:37475202 | DOI:10.1177/19458924231183848
Source: American Journal of Rhinology and Allergy - July 21, 2023 Category: ENT & OMF Authors: Yousif Alammar Simon Rousseau Martin Desrosiers Marc A Tewfik Source Type: research