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Prospective assessment of diagnostic tests for pediatric penicillin allergy, from clinical history to challenge tests ✰,✰✰,✰✰✰.
CONCLUSION: Conventional predictors of allergy to penicillin performed weakly. The authors propose straightforward penicillin provocation testing in controlled, experienced centers for the diagnosis of non-severe penicillin allergy in children.
PMID: 29803713 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 24, 2018 Category: Allergy & Immunology Authors: Ibáñez MD, Del Río PR, Lasa EM, Joral A, Ruiz-Hornillos J, Muñoz C, Traseira CG, Escudero C, Olaguibel Rivera JM, Garriga-Baraut T, González-de-Olano D, Rosado A, Sanchez-García S, Bustamante SP, Vilchez MAP, Montaño PP, Morillo RC, Iglesia EM, Vil Tags: Ann Allergy Asthma Immunol Source Type: research
Multinational experience with hypersensitivity drug reactions in Latin America.
CONCLUSION: Nonsteroidal anti-inflammatory drugs and antibiotics were the drugs used in at least 75% of patients. More than half the reactions were treated in the emergency department, whereas epinephrine was administered in fewer than 25% of patients with anaphylaxis. Dissemination of guidelines for anaphylaxis among primary and emergency department physicians should be encouraged.
PMID: 25065979 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - July 24, 2014 Category: Allergy & Immunology Authors: Jares EJ, Sánchez-Borges M, Cardona-Villa R, Ensina LF, Arias-Cruz A, Gómez M, Barayazarra S, Bernstein JA, Serrano CD, Cuello MN, Morfin-Maciel BM, De Falco A, Cherrez-Ojeda I, Latin America Drug Allergy Interest Group Tags: Ann Allergy Asthma Immunol Source Type: research
Chronic sinusitis pathophysiology: The role of allergy.
CONCLUSION: Treatments of this disease include agents directed at allergic mediators such as leukotriene modifiers and corticosteroids, although this doesnot necessarily signify that an IgE-dependent mechanism can be ascribed. However, more recently, omalizumab has shown promise, including in patientswithout obvious aeroallergen sensitization. Although many aspects of the role of allergy in CHES remain a mystery, the mechanisms that are being elucidatedallow for improved understanding of this disease, which ultimately will lead to better treatments for our patients who live daily with this disease.
PMID: 23601202 [Pub...
Source: American Journal of Rhinology and Allergy - April 18, 2013 Category: ENT & OMF Authors: Kennedy JL, Borish L Tags: Am J Rhinol Allergy Source Type: research
The impact and treatment of allergic rhinitis in the Middle East: A comparison with the landmark allergy surveys from other worldwide regions.
CONCLUSION: There remains an unmet need in the treatment of nasal allergies worldwide. The allergy surveys highlight the key factors in choosing an INCS: fast, complete, and long-lasting symptom relief. There is opportunity for novel INCS treatments that address these needs while reducing troublesome side effects. Patient education must play a central role in treatment decision making, particularly in the Middle East, to achieve higher patient satisfaction.
PMID: 24070203 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - September 6, 2013 Category: ENT & OMF Tags: Am J Rhinol Allergy Source Type: research
Factors associated with negative histamine control for penicillin allergy skin testing in the inpatient setting.
CONCLUSION: Regression analysis supports ICU stay during skin testing as associated with a high OR for a negative histamine response independent of age. Systemic corticosteroids, H2 blockers, and older age are associated with a significant OR for a negative histamine response. This is one of largest studies on factors associated with a negative histamine response for the inpatient setting and has significant implications for clinical practice.
PMID: 25959032 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 7, 2015 Category: Allergy & Immunology Authors: Geng B, Thakor A, Clayton E, Finkas L, Riedl MA Tags: Ann Allergy Asthma Immunol Source Type: research
Monoclonal antibodies in allergy; updated applications and promising trials.
Authors: Ozdemir C
Abstract
Allergic disorders, as asthma, allergic rhinitis/rhinoconjunctivitis, atopic dermatitis, food allergies and anaphylaxis have an increasing burden in the general population and a growing body of evidence has shown that an increased interest has aroused to seek for more effective treatment strategies. Conventional pharmacotherapy by antihistamines, anti-leukotrienes, corticosteroids and bronchodilators can routinely control most of the cases, in addition to allergen avoidance which saves the date. Furthermore, allergen specific immunotherapy stands as the only curative method to treat the ...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 4, 2015 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
An update on ocular allergy
Purpose of review: The update reviews prevalence, classification, cause, and treatment options for allergic eye disease.
Recent findings: The incidence of allergic eye disease is underreported but may affect almost all patients with allergic rhinitis. Increased rates of oculonasal symptoms have been reported in the United States resulting in significant economic expenditures. The spectrum of allergic conjunctivitis and its differential considerations include seasonal and perennial conjunctivitis, vernal and atopic keratoconjunctivitis, and giant papillary conjunctivitis. Patients with allergic conjunctivitis have classic ...
Source: Current Opinion in Allergy and Clinical Immunology - September 2, 2016 Category: Allergy & Immunology Tags: EYE ALLERGY: Edited by Leonard Bielory and Abraham Solomon Source Type: research
The Relation of Allergy to Adenoid Hypertrophy and Otitis Media with Effusion: A Cross-sectional Study.
According to this study, atopy was relatively common in patients with AHT and OME. Treatment with nasal corticosteroid and antihistamines were effective in these patients.
PMID: 33463120 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - October 18, 2020 Category: Allergy & Immunology Authors: Bemanian MH, Rezaei K, Atighechi S, Shafiei A Tags: Iran J Allergy Asthma Immunol Source Type: research
Trends in prevalence and treatment of ocular allergy
Purpose of reviewThis review describes recent findings and trends in prevalence and treatment of allergic ocular diseases. Although the major focus is on seasonal and perennial allergic conjunctivitis, related disorders will also be considered.
Recent findingsPublished reports from countries around the world suggest that the spectrum of atopic diseases, including seasonal and perennial allergic conjunctivitis, is continuing its pattern of increasing prevalence, which has been well documented over the past few decades. In addition, although treatment modalities have focused on topical formulations including antihistamines a...
Source: Current Opinion in Allergy and Clinical Immunology - October 1, 2014 Category: Allergy & Immunology Tags: EYE ALLERGY: Edited by Leonard Bielory and Francesca Levi-Schaffer Source Type: research
Sublingual Immunotherapy Improves Dust Mite AllergySublingual Immunotherapy Improves Dust Mite Allergy
Therapy reduced time to first exacerbation of allergy-related asthma during corticosteroid reduction but yielded no changes in asthma control or quality-of-life questionnaires. Medscape Medical News
Source: Medscape Allergy Headlines - April 27, 2016 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news
4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research
Which infants with eczema are at risk of food allergy? Results from a population‐based cohort
Conclusion and Clinical RelevanceEczema, across the clinical severity spectrum in infancy, is a strong risk factor for IgE‐mediated food allergy. Infants with eczema were 6 times more likely to have egg allergy and 11 times more likely to have peanut allergy by 12 months than infants without eczema. Our data suggest that a heightened awareness of food allergy risk among healthcare practitioners treating infants with eczema, especially if early onset and severe, is warranted.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - September 1, 2014 Category: Allergy & Immunology Authors: Pamela E Martin, Jana K Eckert, Jennifer J Koplin, Adrian J Lowe, Lyle C Gurrin, Shyamali C Dharmage, Peter Vuillermin, Mimi LK Tang, Anne‐Louise Ponsonby, Melanie Matheson, David J Hill, Katrina J Allen, Tags: Original Article‐Epidemiology of Allergic Disease Source Type: research
Steroid allergy: Clinical features and the importance of excipient testing in a diagnostic algorithm
Conclusion Patients with respiratory manifestations were significantly more likely to be truly allergic. CS allergies are rare and may be over-diagnosed without excipient testing. We suggest the use of Carmellose eye drops as a readily available source of carboxymethylcellulose for testing and propose a comprehensive diagnostic algorithm for suspected CS allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 1, 2018 Category: Allergy & Immunology Source Type: research
Steroid Allergy: Clinical Features and the Importance of Excipient Testing in a Diagnostic Algorithm
ConclusionsPatients with respiratory manifestations were significantly more likely to be truly allergic. CS allergies are rare and may be overdiagnosed without excipient testing. We suggest the use of Carmellose eye drops as a readily available source of carboxymethylcellulose for testing and propose a comprehensive diagnostic algorithm for suspected CS allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research
Assessment of current practice of paediatric respiratory and allergy teams in Cambridge University Hospital during the COVID-19 pandemic era and optimisation of the service
Introduction: The paediatric respiratory and allergy teams in Cambridge Hospital see patients with atopic and overlapping conditions, thus increasing travel for patients and hospital footfall. It is a tertiary reference hospital covering East England. Assessment of practice and changes of the service, in view of COVID-19 pandemic.Method: Retrospective assessment of patients: a) referred between the specialties (1/4/19- 31/3/20), investigations booked (lung function, skin prick testing, specific IgE, peak flow, inhaler and nasal spray technique) and patient flow. b) currently being seen by both teams (1/4/18-31/3/20).R...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Powell, E., Nethercott, S., Ali, A., Wilson, G., Zolkipli, Z., Mcshane, D., Kotzia, D. Tags: Paediatric asthma and allergy Source Type: research
