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Total 472 results found since Jan 2013.
Impact of induction chemotherapy and socioeconomics on sinonasal undifferentiated carcinoma survival
ConclusionIn this SNUC population ‐based analysis, IC did not appear to provide additional OS benefit regardless of disease stage or timing before definitive treatment. Distance to treatment and level of comorbidities may be associated with receiving IC, whereas type of insurance and residence education level may impact SNUC OS, r egardless of treatment.
Source: International Forum of Allergy and Rhinology - May 11, 2020 Category: Allergy & Immunology Authors: Brandon M. Lehrich,
Khodayar Goshtasbi,
Arash Abiri,
Tyler Yasaka,
Ronald Sahyouni,
Peter Papagiannopoulos,
Bobby A. Tajudeen,
Edward C. Kuan Tags: ORIGINAL ARTICLE Source Type: research
Goal-directed therapy with bolus albumin 5% is not superior to bolus ringer acetate in maintaining systemic and mesenteric oxygen delivery in major upper abdominal surgery: A randomised controlled trial
CONCLUSION
Bolus human albumin 5% was not superior to bolus ringer acetate in maintaining systemic or mesenteric oxygen delivery in elective major upper gastrointestinal cancer surgery, despite the administration of larger volumes of trial fluid in the ringer acetate group. No significant difference was seen in fluid-related complications or LOS.
TRIAL REGISTRATION
https://eudract.ema.europa.eu/ Identifier: 2013-002217-36.
Source: European Journal of Anaesthesiology - May 11, 2020 Category: Anesthesiology Tags: Haemodynamics Source Type: research
Novel Roles for Platinum and Taxane Agent Skin Testing in Risk Stratification of Chemotherapy Hypersensitivity
Publication date: May 2020Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 8, Issue 5Author(s): Iris M. Otani, Mariana Castells
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 6, 2020 Category: Allergy & Immunology Source Type: research
A multi ‐institutional review of outcomes in biopsy‐proven chronic invasive fungal sinusitis
ConclusionWe present a multi ‐institutional case‐series of CIFS and long‐term follow‐up. ANC<1000 at time of diagnosis and recent chemotherapy (within 1 month of diagnosis) are associated with poorer survival, whereas a rising ANC>1000 is associated with improved survival at 12 months. Further prospective studies are needed to further define factors that affect outcomes.
Source: International Forum of Allergy and Rhinology - April 12, 2020 Category: Allergy & Immunology Authors: Ian M. Humphreys,
Grace M. Wandell,
Craig Miller,
Aakanksha Rathor,
Rodney A. Schmidt,
Justin H. Turner,
Peter H. Hwang,
Greg E. Davis Tags: ORIGINAL ARTICLE Source Type: research
Comparison of pegylated liposomal doxorubicin and paclitaxel plus carboplatin-based chemotherapy as first line treatment for patients with ovarian cancer: a systematic review and meta-analysis of randomized controlled trials.
Authors: Shi SQ, Jiang FF, Hong T, Zhuang Y, Chen L, Huang XL
Abstract
We reviewed studies comparing survival outcomes such as overall survival (OS), progression free survival (PFS), and toxicity profile between patients treated with Pegylated Liposomal Doxorubicin (PLD) combination and those treated with paclitaxel combination for ovarian cancer. We conducted systematic searches in various databases including Medline, Cochrane Controlled Register of Trials (CENTRAL), ScienceDirect, and Google Scholar from inception until August 2019. We used the Cochrane risk of bias tool to assess the quality of published trials....
Source: European Review for Medical and Pharmacological Sciences - April 10, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Drug Eyed As Potential Coronavirus Treatment Being Hoarded, Leaving Patients In Need Without
BOSTON (CBS) – A drug that President Donald Trump has touted as a possible treatment for coronavirus is now in short supply. While the FDA has not yet approved hydroxychloroquine for COVID-19, some people are hoarding it, leaving patients who regularly rely on the medication scrambling.
“It would be a gift from God if that worked. It would be a big game changer,” Trump said of the anti-malarial drug.
Dr. Anthony Fauci, the Director of the National Institute of Allergy and Infectious Disease, and a prominent member of the White House Coronavirus Task Force has cautioned that evidence of its effectiveness in treating c...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - March 24, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Syndicated CBSN Boston Syndicated Local Coronavirus Source Type: news
Pneumocystis jirovecii Pneumonia in Patients With Metastatic Prostate Cancer on Corticosteroids for Malignant Spinal Cord Compression: Two Case Reports and a Guideline Review.
This article will also provide a review of the current guidelines for PCP prophylaxis in patients undergoing treatment for metastatic spinal cord compression. We recommend empiric treatment with trimethoprim-sulfamethoxazole or dapsone in those patients with a sulfa allergy in all patients with solid tumors when any high-dose steroids are started for the treatment of metastatic spinal cord compression. Further research is needed to assess the epidemiology of PCP in patients with solid tumors and additional trials are necessary to refine PCP prophylaxis.
PMID: 32212136 [PubMed - in process]
Source: Oncology (Williston Park, N.Y.) - March 18, 2020 Category: Cancer & Oncology Authors: Duarte C, Gilbert D, Sheridan AD, PharmaD SDW, Lam ET Tags: Oncology (Williston Park) Source Type: research
Incidence, risk factors, and outcomes of endoscopic sinus surgery after endoscopic skull ‐base surgery
ConclusionA significant proportion of patients develop clinically significant sinusitis after endoscopic SBS for neoplasms with combined sinonasal and skull base involvement and may benefit from rESS. Intervention occurred, on average, 3.5 years after initial tumor resection. Malignant pathology, radiation therapy, and chemotherapy correlate with need for rESS.
Source: International Forum of Allergy and Rhinology - February 28, 2020 Category: Allergy & Immunology Authors: Ravi R. Shah,
Ivy W. Maina,
Neil N. Patel,
Vasiliki Triantafillou,
Alan D. Workman,
Edward C. Kuan,
Charles C.L. Tong,
Michael A. Kohanski,
Bert W. O'Malley,
Nithin D. Adappa,
James N. Palmer Tags: ORIGINAL ARTICLE Source Type: research
Impact of induction chemotherapy and socioeconomics on sinonasal undifferentiated carcinoma survival
ConclusionIn this SNUC population ‐based analysis, IC did not appear to provide additional OS benefit regardless of disease stage or timing before definitive treatment. Distance to treatment and level of comorbidities may be associated with receiving IC, whereas type of insurance and residence education level may impact SNUC OS, r egardless of treatment.
Source: International Forum of Allergy and Rhinology - February 28, 2020 Category: Allergy & Immunology Authors: Brandon M. Lehrich,
Khodayar Goshtasbi,
Arash Abiri,
Tyker Yasaka,
Ronald Sahyouni,
Peter Papagiannopoulos,
Bobby A. Tajudeen,
Edward C. Kuan Tags: ORIGINAL ARTICLE Source Type: research
Immediate Hypersensitivity Reaction to Chemotherapy in Pediatric Malignancies
This study aims to review clinical features of patients who had immediate hypersensitivity to chemotherapeutic agents.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Chanaphorn Mokkhamakkun, Jassada Buaboonnam, Witchaya Srisuwatchari, Orathai Piboonpocanun, Nualanong Visitsunthorn, Punchama Pacharn Source Type: research
Intimal sarcoma of pulmonary arteries.
Abstract
Pulmonary arterial intimal sarcoma is a rare tumour with high mortality. Due to its localisation, the symptoms can mimic pulmonary thromboembolism and pneumonia, therefore assessing the diagnosis and choosing the adequate therapy is never easy. Its therapy mainly consists of surgery combined with radiochemotherapy. A 46-year-old male patient with testicular seminoma, pulmonary embolism, bronchial asthma and pollen allergy in his history had a follow-up thoracic CT. On the left side of the lung, a pleura-infiltrating 7-8 cm lesion, which occluded the pulmonary artery, was described. The first biopsy specim...
Source: Orvosi Hetilap - January 31, 2020 Category: General Medicine Authors: Sejben A, Tiszlavicz L, Furák J, Boros K, Sápi Z, Zombori T Tags: Orv Hetil Source Type: research
Biomarkers Associated with Hypersensitivity Reactions to Chemotherapeutic Agents.
New phenotypes of hypersensitivity reactions (HSR) have been described due to the wide use of chemotherapy, however, biomarkers other than tryptase to confirm the reaction are not feasible. Our goal was to determine the value of tryptase and IL-6 during desensitization to chemotherapy agents.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: F. Javier Fernandez, Teodorikez Jimenez Rodriguez, Maria Ruano-Zaragoza, Purificaci ón Gonzalez-Delgado, Victor Soriano-Gomis Source Type: research
Anaphylaxis —a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis
Anaphylaxis is an acute, potential life-threatening systemic allergic reaction that may have a wide range of clinical manifestations. Severe anaphylaxis and/or the need for repeated doses of epinephrine to treat anaphylaxis are risk factors for biphasic anaphylaxis. Antihistamines and/or glucocorticoids are not reliable interventions to prevent biphasic anaphylaxis, although evidence supports a role for antihistamine and/or glucocorticoid premedication in specific chemotherapy protocols and rush aeroallergen immunotherapy.
Source: Journal of Allergy and Clinical Immunology - January 26, 2020 Category: Allergy & Immunology Authors: Marcus S. Shaker, Dana V. Wallace, David B.K. Golden, John Oppenheimer, Jonathan A. Bernstein, Ronna L. Campbell, Chitra Dinakar, Anne Ellis, Matthew Greenhawt, David A. Khan, David M. Lang, Eddy S. Lang, Jay A. Lieberman, Jay Portnoy, Matthew A. Rank, Da Tags: Practice parameter Source Type: research
Importance of Diagnostics Prior to Desensitization in New Drug Hypersensitivity: Chemotherapeutics and Biologicals
AbstractPurpose of reviewIn this review article, we intend to summarize the diagnostic tools available for the study of drug hypersensitivity reactions to chemotherapy and biologicals, based on the experience and controversies of the main research groups leading the topic.Recent findingsRecent publications with large cohorts of patients reacting to these drugs are allowing for a better understanding of phenotyping, endotyping, and optimally managing these patients.SummaryThere is a remarkable heterogeneity on the diagnostic and therapeutic approach among the different groups, and yet this has allowed for very interesting d...
Source: Current Treatment Options in Allergy - January 9, 2020 Category: Allergy & Immunology Source Type: research
