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Molecular Characteristics of Bladder Tumor: Increased Gene Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and MicroRNA-125b
Iran J Allergy Asthma Immunol. 2022 Oct 26;21(5):561-573. doi: 10.18502/ijaai.v21i5.11043.ABSTRACTBladder cancer is recognized as one of the top ten most common cancers worldwide. Activation of oncogenes, inactivation of tumor suppressor genes, and dysregulation of androgen signaling pathways are three major pathophysiological causes in the development of bladder tumors. Discovering potential biomarkers is required for the management and immunotherapy of bladder cancer. Melanoma-associated antigen (MAGE)-A6 and MAGE-A11 are two cancer-testis antigens that are potential coregulators of androgen receptors. MicroRNAs, especia...
Source: Iranian Journal of Allergy, Asthma and Immunology - November 7, 2022 Category: Allergy & Immunology Authors: Azin Aghamajidi Zahra Ousati Ashtiani Monireh Mohsenzadegan Nader Tajik Mahmood Ghafoori Yazdi Laleh Sharifi Mohammad Reza Nowroozi Source Type: research
