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Total 472 results found since Jan 2013.

Device-assisted intravesical chemotherapy versus bacillus Calmette –Guerin for intermediate or high-risk non-muscle invasive bladder cancer: a systematic reviewer and meta-analysis
ConclusionDevice-assisted intravesical chemotherapy appears to be a safe and viable alternative to BCG for patients with intermediate and high-risk NMIBC, showing comparable oncological outcomes and adverse events.
Source: International Urology and Nephrology - September 2, 2023 Category: Urology & Nephrology Source Type: research

Anti-tumor activity of trimethoprim-sulfamethoxazole against melanoma skin cancer through triggering allergic reaction and promoting immunity
This study examined the potential roles of TMP-SMX in melanoma skin cancer using an immunodeficient mouse model. TMP-SMX significantly improved the survival rate and reduced the tumor weight and growth and vascular endothelial growth factor levels in melanoma skin cancer of immunodeficient mice. In the forced swimming test, TMP-SMX significantly reduced immobility time compared to the melanoma skin cancer of immunodeficient mice, indicating improved immunity. TMP-SMX significantly increased infiltration of mast cells and release of allergy-related mediators (IgE, histamine, interleukin (IL)-4, IL-5, IL-13, and IL-33) and i...
Source: International Immunopharmacology - August 3, 2023 Category: Allergy & Immunology Authors: Hee-Yun Kim Ho-Geun Kang Hyung-Min Kim Hyun-Ja Jeong Source Type: research

Impact of histamine-2 antagonist shortage on the incidence of hypersensitivity reactions to paclitaxel: a reconsideration of premedication protocols in France (PACLIREACT Study)
ConclusionWe did not find substantial evidence of an increased risk of HSR due to the absence of H2A in the premedication protocols for paclitaxel. Thus, in contrary to the existing literature on paclitaxel, our findings support the use of a premedication protocol without H2A.
Source: European Journal of Clinical Pharmacology - July 13, 2023 Category: Drugs & Pharmacology Source Type: research

Cytokine profiling, pretreatment with anakinra, and tolerance development in platinum-induced mixed hypersensitivity reactions
CONCLUSION: In patients with platinum-induced CRR, anakinra could be a useful premedication to block its clinical manifestations, and monitoring of IL-2, IL-5, IL-6, IL-10 and TNF-a could help predict tolerance development thereby allowing safe adjustments to the desensitization protocol and premedication.PMID:37321446 | DOI:10.1016/j.anai.2023.06.011
Source: Annals of Allergy, Asthma and Immunology - June 15, 2023 Category: Allergy & Immunology Authors: Matthieu Picard Charles Alexandre Filion Marie-H élène Auclair Jonathan Noujaim Lara de Guerk é Jean-Luc Dionne Julie Beaudet Carl Amireault Suzanne Fortin Source Type: research

The use of aprepitant for the prevention of postoperative nausea and vomiting in endoscopic transsphenoidal pituitary surgery
Conclusion: Aprepitant may serve as a useful preoperative treatment to reduce PONV in patients undergoing TSA. Further studies are needed to evaluate its impact in other arenas of endoscopic skull base surgery.This article is protected by copyright. All rights reserved
Source: International Forum of Allergy and Rhinology - June 12, 2023 Category: Allergy & Immunology Authors: Daniel J. Lee, Jennifer E. Douglas, Jeremy Chang, Jadyn Wilensky, Christina Jackson, John Y.K. Lee, M. Sean Grady, Daniel Yoshor, Michael A. Kohanski, James N. Palmer, Joshua H. Atkins, Nithin D. Adappa Tags: ORIGINAL ARTICLE Source Type: research

Drug Combo Shows Positive Results in Late-Stage Cancer Trial Drug Combo Shows Positive Results in Late-Stage Cancer Trial
AstraZeneca said a combo of cancer drugs Imfinzi and Lynparza when added to platinum-based chemotherapy showed positive results in a late-stage trial for endometrial cancer.Reuters Health Information
Source: Medscape Allergy Headlines - May 30, 2023 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news

In-Class Cross-Reactivity among Hospitalized Patients with Hypersensitivity Reactions to Fluoroquinolones
Antimicrob Agents Chemother. 2023 May 8:e0037423. doi: 10.1128/aac.00374-23. Online ahead of print.ABSTRACTResults from this large, multicenter study suggest that patients with a confirmed ciprofloxacin, moxifloxacin, or levofloxacin hypersensitivity reaction are likely to tolerate other fluoroquinolones. Avoiding different fluoroquinolones in patients labeled with a ciprofloxacin, moxifloxacin, or levofloxacin allergy may not always be mandatory. This was a study of patients with a ciprofloxacin, moxifloxacin, or levofloxacin hypersensitivity reaction and a documented electronic medical record administration of a differen...
Source: Antimicrobial Agents and Chemotherapy - May 8, 2023 Category: Microbiology Authors: Sunish Shah Lloyd G Clarke Kathleen K Adams Source Type: research

Relevance of the diagnosis of hypersensitivity reactions to antineoplastic and biological agents: experience with drug provocation test
Conclusions. DPT followed by RSA allowed to exclude HSRs in 45 patients (55 culprit drugs). DPT before desensitization prevents non-hypersensitivity patients from undergoing RDD. In our study DPT was safe, all reactions were managed by an allergist.PMID:37133313 | DOI:10.23822/EurAnnACI.1764-1489.296
Source: European Annals of Allergy and Clinical Immunology - May 3, 2023 Category: Allergy & Immunology Authors: J Queir ós Gomes L P Pereira Dias P Barreira J Barradas Lopes M J Sousa S Cadinha D Malheiro Source Type: research