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Total 472 results found since Jan 2013.
Covid-19 vaccine reactions and suspected polyethylene glycol allergy: a pediatric case series
Studies have demonstrated tolerance in high risk patients receiving Covid-19 m-RNA vaccines containing polyethylene glycol (PEG) with rare reactions.There is limited pediatric data regarding safety in receiving PEG containing Covid-19 vaccines with a history of prior hypersensitivity reactions to PEG containing chemotherapy (PEG-CTX).
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: M. Laditan, A. Martone, D. Doshi Tags: P010 Source Type: research
A case of hereditary alpha tryptasemia masquerading as chemotherapy hypersensitivity reaction
We present a case of HaT diagnosed after hypersensitivity reactions to chemotherapeutic agents treated with a prolonged desensitization protocol.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: R. Monahan, K. Ige, J. Zheng, I. Otani, L. Tsao Tags: M042 Source Type: research
Abraxane desensitization
We present a case of severe hypersensitivity to Taxol and a unique protocol for Abraxane desensitization.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: K. Bansal, M. Patel, A. Ciliberti, E. Konsur, M. Mahdavinia Tags: M011 Source Type: research
Meropenem plus Ceftaroline Is Active against Enterococcus faecalis in an < em > In Vitro < /em > Pharmacodynamic Model Using Humanized Dosing Simulations
Antimicrob Agents Chemother. 2022 Sep 26:e0042622. doi: 10.1128/aac.00426-22. Online ahead of print.ABSTRACTThe standard of care for serious Enterococcus faecalis infections is ampicillin plus ceftriaxone. Ampicillin's inconvenient dosing schedule, drug instability, allergy potential, along with ceftriaxone's high risk for Clostridioides difficile infection and its promotion of vancomycin-resistant enterococci (VRE), led our team to explore alternative options. This work aimed to understand the role of carbapenems in combination with cephalosporins in these infections. We selected two ampicillin and penicillin susceptible ...
Source: Antimicrobial Agents and Chemotherapy - September 26, 2022 Category: Microbiology Authors: Jaclyn A Cusumano Kathryn E Daffinee Emily C Piehl M ónica García-Solache Charlene Desbonnet Louis B Rice Kerry L LaPlante Source Type: research
Combined IFN γ and JAK inhibition to treat hemophagocytic lymphohistiocytosis in mice
CONCLUSIONS: Our findings demonstrate that IFNγ blockade and ruxolitinib act synergistically to suppress HLH progression. This supports the use of combined cytokine-targeted therapies as a bridge to HCT in severe fHLH.PMID:35973477 | DOI:10.1016/j.jaci.2022.07.026
Source: Cancer Control - August 16, 2022 Category: Cancer & Oncology Authors: Jos ée-Anne Joly Alexis Vall ée Benoite Bourdin Sara Bourbonnais Natalie Patey Louis Gaboury Yves Th éorêt H élène Decaluwe Source Type: research
A case of acute focal bacterial nephritis caused by methicillin-resistant < em > Staphylococcus saprophyticus < /em > in a 13-year-old adolescent girl treated with daptomycin
IDCases. 2022 Aug 6;29:e01594. doi: 10.1016/j.idcr.2022.e01594. eCollection 2022.ABSTRACTStaphylococcus saprophyticus is a gram-positive, coagulase-negative member of the Staphylococcus genus and is second only to Escherichia coli as a cause of urinary tract infections in the young female population. S. saprophyticus usually has good susceptibility to drugs commonly used to treat urinary tract infections, but it is often methicillin-resistant. Here we report a case of acute focal bacterial nephritis in a 13-year-old female patient caused by methicillin-resistant S. saprophyticus and treated with daptomycin (DAP). The patie...
Source: Pain Physician - August 15, 2022 Category: Anesthesiology Authors: Teruhisa Kinoshita Shoko Sahara Yuka Mihara Yumiko Asai Hiroko Sato Takashi Sakakibara Norio Takimoto Keisuke Oka Source Type: research
Combined IFN- γ and JAK inhibition to treat hemophagocytic lymphohistiocytosis in mice
Familial hemophagocytic lymphohistiocytosis is a life-threatening hyperinflammatory disease caused by genetic defects in the granule-mediated cytotoxic pathway. Success of hematopoietic cell transplantation, the only cure, is correlated with the extent of disease control before transplantation. Unfortunately, disease refractoriness and toxicities to standard chemotherapy-based regimens are fatal in a fraction of patients. Novel targeted immunotherapies, such as IFN- γ blocking antibodies or ruxolitinib, a Janus kinase (JAK) 1/2 inhibitor, are promising but only partially effective at controlling disease.
Source: Journal of Allergy and Clinical Immunology - August 13, 2022 Category: Allergy & Immunology Authors: Jos ée-Anne Joly, Alexis Vallée, Benoîte Bourdin, Sara Bourbonnais, Natalie Patey, Louis Gaboury, Yves Théorêt, Hélène Decaluwe Source Type: research
Survival Boost With Neoadjuvant Chemo-Immunotherapy in NSCLC Survival Boost With Neoadjuvant Chemo-Immunotherapy in NSCLC
Adding neoadjuvant nivolumab to chemotherapy in stage IIIA/IIIB non ¬–small cell lung cancer markedly improves both progression-free and overall survival over neoadjuvant chemotherapy alone.Medscape Medical News
Source: Medscape Allergy Headlines - August 10, 2022 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
What Are Causes of Childhood Interstital Lung Disease?
Discussion
Interstitial lung disease in children (chILD) is less understood than adult interstitial lung disease (ILD) and is rare. Prevalence is ~ 0.13 to 16.2 per 100,000 children under age 17 years. chILD is an general term for respiratory disorders that are heterogeneous, chronic and impair lung function. While some define diffuse parenchymal lung disease (DPLD) separately, the term ILD usually encompases DPLD. chILD has variable definitions and is “usually diagnosed if three of the following features are present:
1) respiratory symptoms (cough, rapid and/or difficult breathing, and exercise intolerance),
2) res...
Source: PediatricEducation.org - August 1, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Management of adverse reactions induced by chemotherapy drugs
Purpose of review
There is a broad spectrum of chemotherapy-induced adverse reactions. Hypersensitivity reactions are being extensively studied as they can affect the ideal treatment. The goal of this review is to describe the current management of adverse reactions to chemotherapy, focusing on hypersensitivity events.
Recent findings
The range of possible desensitization protocols is increasing, as well as the delabeling algorithms and diagnostic tools. One-bag desensitization protocols, omalizumab use in immediate hypersensitivity reactions, slow desensitization protocols in nonimmediate hypersensitivity react...
Source: Current Opinion in Allergy and Clinical Immunology - July 27, 2022 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Paul Whitaker and Luciana K. Tanno Source Type: research
New Technical Aspects Used in the Management of Desensitization to Antineoplastic Drugs
AbstractPurpose of ReviewThis review will focus on the most recent technical developments in rapid drug desensitization to antineoplastic agents (chemotherapy and biologics). It is designed as an update for the initiated and not a review of fundamental concepts.Recent FindingsThe recent publication of several international guidelines on diagnosing and managing drug hypersensitivity reactions to chemotherapy and biologics is set to revolutionize this field for allergy specialists. These guidelines resulted from leading groups coming together and collaborating to facilitate that allergy departments worldwide could expand the...
Source: Current Treatment Options in Allergy - July 25, 2022 Category: Allergy & Immunology Source Type: research
COMMENTARY: Adjuvant vs Neoadjuvant for Resectable NSCLC? COMMENTARY: Adjuvant vs Neoadjuvant for Resectable NSCLC?
Which is better? Concurrent neoadjuvant chemotherapy and immunotherapy or concurrent adjuvant chemotherapy with immunotherapy for non –small cell lung cancer (NSCLC)?Medscape Medical News
Source: Medscape Allergy Headlines - July 15, 2022 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
Eugenol: A New Option in Combination Therapy with Sorafenib for the Treatment of Undifferentiated Thyroid Cancer
This study investigated whether eugenol in combination with sorafenib was more effective than either substance individually in triggering apoptosis in the UTC. The IC50 of sorafenib and eugenol was determined in a UTC cell line (8305C) by MTT assay, and their synergistic effect in combination therapy was investigated. Flow cytometry was used to evaluate the rate of apoptosis in treated cells. To confirm that cell death occurred through apoptosis, immunoblotting was used to determine the relative cleavage of caspase-8 and caspase-9. The IC50 of sorafenib was 20 µM, and that of eugenol was 2100 µM. The sorafenib-eugenol co...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Pedram Talezadeh Shirazi Shirin Farjadian Mohammad Hossein Dabbaghmanesh Hossein Jonaidi Ali Alavianmehr Mehdi Kalani Ladan Emadi Source Type: research
