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Procedure: Liver Transplant

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Total 226 results found since Jan 2013.

Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments
Transthyretin (ATTR) amyloidosis is a life-threatening, gain-of-toxic-function disease characterised by extracellular deposition of amyloid fibrils composed of transthyretin (TTR). TTR protein destabilised by TTR gene mutation is prone to dissociate from its native tetramer to monomer, and to then misfold and aggregate into amyloid fibrils, resulting in autosomal dominant hereditary amyloidosis, including familial amyloid polyneuropathy, familial amyloid cardiomyopathy and familial leptomeningeal amyloidosis. Analogous misfolding of wild-type TTR results in senile systemic amyloidosis, now termed wild-type ATTR amyloidosis...
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 13, 2015 Category: Neurosurgery Authors: Sekijima, Y. Tags: Genetics, Immunology (including allergy), Neuromuscular disease, Peripheral nerve disease General neurology Source Type: research

Outcome of children with hereditary tyrosinaemia following newborn screening
Conclusions Universal NBS for HT1 should be introduced in the UK.
Source: Archives of Disease in Childhood - July 17, 2015 Category: Pediatrics Authors: McKiernan, P. J., Preece, M. A., Chakrapani, A. Tags: Liver disease, Oncology, Immunology (including allergy), Child health, Disability, Screening (epidemiology), Artificial and donated transplantation, Metabolic disorders, Screening (public health) Original article Source Type: research

Tacrolimus use in renal and cardiac pediatric transplantation: no increased risk of food allergies
The objective of this study was to establish whether TAFA was observed after renal and cardiac transplantations and to determine whether the type of solid organ transplanted and/or immunosuppression protocol played a role in the development of TAFA.
Source: Annals of Allergy, Asthma and Immunology - June 18, 2015 Category: Allergy & Immunology Authors: François Graham, Frédéric Racicot, Luminita Jamali, Véronique Phan Cong, Marie-Josée Raboisson, Jean Paradis, Louis Paradis, Anne Des Roches Tags: Letter Source Type: research

Long‐term outcome of food allergy after liver transplantation in children
Source: Pediatric Transplantation - April 16, 2015 Category: Transplant Surgery Authors: Ozlem Yilmaz Ozbek, Figen Ozcay Tags: Letter to the Editor Source Type: research

Intraoperative anaphylaxis likely due to Gelfoam in a pediatric patient undergoing liver biopsy
We report on a case of intraoperative anaphylaxis to Gelfoam (Pfizer, New York, New York) in a pediatric patient undergoing a liver biopsy procedure. A 10-year-old girl with a history of orthotropic cardiac transplantation on chronic immunosuppression (tacrolimus and prednisone) complicated by post-transplantation lymphoproliferative disease presented for liver biopsy examination to evaluate hepatic dysfunction.
Source: Annals of Allergy, Asthma and Immunology - April 14, 2015 Category: Allergy & Immunology Authors: Karen A. Robbins, Corinne A. Keet Tags: Letter Source Type: research

Review article: spontaneous bacterial peritonitis – bacteriology, diagnosis, treatment, risk factors and prevention
ConclusionsThird‐generation, broad‐spectrum cephalosporins remain a good initial choice for SBP treatment. Levofloxacin is an acceptable alternative for patients not receiving long‐term flouroquinolone prophylaxis or for those with a penicillin allergy. For uncomplicated SBP, early oral switch therapy is reasonable. Alternative antibiotics such as pipercillin–tazobactam should be considered for patients with nosocomial SBP or for patients who fail to improve on traditional antibiotic regimens. Selective albumin supplementation remains an important adjunct in SBP treatment. Withholding acid suppressive medication de...
Source: Alimentary Pharmacology and Therapeutics - March 27, 2015 Category: Drugs & Pharmacology Authors: J. B. Dever, M. Y. Sheikh Tags: Review Article Source Type: research

Evaluation of the Effect of Ascorbic Acid Administration on Gene Expression Level of IL-6 and TNF-α Cytokines in Deceased Donors.
Abstract Brain death is associated with increased inflammatory cytokines levels and poor graft quality to transplant. We aimed to evaluate the impact of Ascorbic Acid (AA) on the inflammatory status of Brain-Dead Donors (BDDs). Forty BDDs were randomly divided into two groups. Donor treatment (n=20) consisted of 100 mg/kg AA infusion 6 hours before donor operation and subsequent infusion of 100 mg/kg/p6h until organ removal. Blood samples were taken at three times, 6 hours before donor surgery (TP1), immediately after laparotomy (TP2), and before organ removal (TP3). Gene expression level and serum concentration o...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 18, 2015 Category: Allergy & Immunology Authors: Kazemi M, Tabei SM, Najafizadeh K, Mehrabi Sisakht J, Milani S, Khosravi MB Tags: Iran J Allergy Asthma Immunol Source Type: research

Raised immunoglobulin A and circulating T follicular helper cells are linked to the development of food allergy in pediatric liver transplant patients
ConclusionsLT has an impact on humoral immunity, remarkably in those patients developing FA.The increase in serum markers of mucosal IgA, food allergen specific IgA and cTfh cells observed in LTFA, point towards a disturbance in intestinal immune homeostasis in this patient group.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - February 1, 2015 Category: Allergy & Immunology Authors: Ruth De Bruyne, Philippe Gevaert, Myriam Van Winckel, Natalie De Ruyck, Aurelie Minne, Delfien Bogaert, Stephanie Van Biervliet, Saskia Vande VeldeD, Francoise Smets, Etienne Sokal, Fréderic Gottrand, Jérémy Vanhelst, Bruno Detry, Charles Pilette, Bart Tags: Original Article‐Clinical Mechanisms in Allergic Disease Source Type: research

Transthyretin-type cerebral amyloid angiopathy: a serious complication in post-transplant patients with familial amyloid polyneuropathy
Liver transplantation is a well-established treatment for transthyretin (TTR)-type familial amyloid polyneuropathy (TTR-FAP).1 According to data in the Familial Amyloidotic Polyneuropathy World Transplant Registry (http://www.fapwtr.org/ram_fap.htm), more than 2000 liver transplantations have been performed to date in 19 countries. Transplantation replaces the variant TTR gene with the wild-type gene in the liver, the main source of serum circulating TTR. The serum concentration of variant TTR decreases rapidly, reaching almost zero after the operation. The effects of liver transplantation on neuropathy are evident as its ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 14, 2015 Category: Neurosurgery Authors: Sekijima, Y. Tags: Genetics, Immunology (including allergy), Drugs: CNS (not psychiatric), Epilepsy and seizures, Neuromuscular disease, Peripheral nerve disease, Stroke, Ophthalmology Editorial commentaries Source Type: research

CNS involvement in V30M transthyretin amyloidosis: clinical, neuropathological and biochemical findings
Conclusions Our findings indicate that CNS clinical involvement occurs in ATTR-V30M patients regardless of LT. Longer disease duration after LT can provide the necessary time for transthyretin amyloidosis to progress until it becomes clinically relevant. Highly sensitive imaging methods are needed to identify and monitor brain ATTR. Disease modifying therapies should consider brain TTR as a target.
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 14, 2015 Category: Neurosurgery Authors: Maia, L. F., Magalhaes, R., Freitas, J., Taipa, R., Pires, M. M., Osorio, H., Dias, D., Pessegueiro, H., Correia, M., Coelho, T. Tags: Genetics, Immunology (including allergy), Neuromuscular disease, Peripheral nerve disease, Neuropathology, Radiology, Radiology (diagnostics) Source Type: research

Paracetamol-associated acute liver failure in Australian and New Zealand children: high rate of medication errors
Conclusions In Australia and New Zealand, paracetamol overdose secondary to medication errors is the leading cause of paediatric acute liver failure. A review of regional safety practices surrounding paracetamol use in children is indicated.
Source: Archives of Disease in Childhood - December 15, 2014 Category: Pediatrics Authors: Rajanayagam, J., Bishop, J. R., Lewindon, P. J., Evans, H. M. Tags: Liver disease, ADC Drug Therapy, Immunology (including allergy), Child health, Unwanted effects / adverse reactions, Poisoning, Artificial and donated transplantation, Occupational and environmental medicine Source Type: research

The current status of neonatal organ donation in the UK
Solid organ transplantation provides life-saving treatment for infants and children with liver and cardiac failure, and is the best treatment for end-stage renal disease. In the UK in 2012/2013, 25 infants (<1 year of age) received organ transplants comprising four heart, 17 deceased donor liver and four living donor liver transplants, and as of January 2014, five infants were on the liver transplant waiting list and three were awaiting a heart transplant (personal communication with National Health Service Blood and Transplant (NHSBT)). While infants form only a very small minority on the active transplant waiting list...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 14, 2014 Category: Perinatology & Neonatology Authors: Wright, J. C. E., Barlow, A. D. Tags: Liver disease, Pancreas and biliary tract, Urology, Epidemiologic studies, Small intestine, Stomach and duodenum, Immunology (including allergy), Drugs: cardiovascular system, Coma and raised intracranial pressure, Child health, End of life decisions (pal Source Type: research

North Texas Fracking Zone Sees Growing Health Worries
This story was published by The Center for Public Integrity, a nonprofit, nonpartisan investigative news organization in Washington, D.C. DALLAS—Propped up on a hospital bed, Taylor Ishee listened as his mother shared a conviction that choked her up. His rare cancer had a cause, she believes, and it wasn’t genetics. Others in Texas have drawn the same conclusions about their confounding illnesses. Jana DeGrand, who suffered a heart attack and needed both her gallbladder and her appendix removed. Rebecca Williams, fighting off unexplained rashes, sharp headaches and repeated bouts of pneumonia. Maile Bush, who needed ...
Source: Science - The Huffington Post - December 11, 2014 Category: Science Source Type: news

Human IL-21 and IL-21R deficiencies: two novel entities of primary immunodeficiency
Purpose of reviewThis review highlights the recent identification of human interleukin-21 (IL-21) and interleukin-21 receptor (IL-21R) deficiencies as novel entities of primary immunodeficiency. Recent findingsWe recently described the first patients with IL-21R deficiency who had cryptosporidial infections associated with chronic cholangitis and liver disease. All IL-21R-deficient patients suffered from recurrent respiratory tract infections. Immunological work-up revealed impaired B cell proliferation and immunoglobulin class-switch, reduced T cell effector functions, and variable natural killer cell dysfunctions. Recent...
Source: Current Opinion in Pediatrics - November 7, 2014 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Tala Chatila Source Type: research

Autoimmune BSEP Disease: Disease Recurrence After Liver Transplantation for Progressive Familial Intrahepatic Cholestasis
Abstract Severe cholestasis may result in end-stage liver disease with the need of liver transplantation (LTX). In children, about 10 % of LTX are necessary because of cholestatic liver diseases. Apart from bile duct atresia, three types of progressive familial intrahepatic cholestasis (PFIC) are common causes of severe cholestasis in children. The three subtypes of PFIC are defined by the involved genes: PFIC-1, PFIC-2, and PFIC-3 are due to mutations of P-type ATPase ATP8B1 (familial intrahepatic cholestasis 1, FIC1), the ATP binding cassette transporter ABCB11 (bile salt export pump, BSEP), or ABCB4 (multidrug...
Source: Clinical Reviews in Allergy and Immunology - October 24, 2014 Category: Allergy & Immunology Source Type: research