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Procedure: Liver Transplant

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Total 226 results found since Jan 2013.

Expression Pattern of MicroRNA-21 during the Liver Ischemia/Reperfusion
Iran J Allergy Asthma Immunol. 2021 Feb 11;20(1):88-97. doi: 10.18502/ijaai.v20i1.5415.ABSTRACTIschemia/reperfusion (I/R) injury in cadaveric liver transplantation is not avoidable. Liver I/R injury is an important phenomenon in hepatic damage. MicroRNA-21 (miR-21) plays an important role in I/R injury. The present study aimed to determine the expression pattern of miR-21 in liver I/R injury/recovery and its correlation with the immunologic transmission signals pathways several days post-reperfusion. In an animal model for I/R in the liver, 40 male Balb/c mice were divided into 3 groups. The animals were monitored for 3 an...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Alireza Salah Mohammad Hossein Karimi Javad Sajedianfard Saeed Nazifi Ramin Yaghobi Source Type: research

In lab study, nanoparticle shows promising results for treating severe allergies
For about 1 in 13 children in the U.S., usually harmless foodstuffs such as milk, eggs and peanuts can send the body ’s natural defenses into overdrive.Symptoms of food allergies can vary widely, but at worst, a systemwide allergic response can lead to anaphylaxis, a life-threatening condition characterized by a sudden drop in blood pressure and difficulty breathing.Although there are now some preventive measures for food-induced anaphylaxis, there are not yet any long-lasting solutions — treatments capable of locking the immune system into a state of tolerance, so that it doesn’t respond to allergens.Now, a UCLA res...
Source: UCLA Newsroom: Health Sciences - January 14, 2021 Category: Universities & Medical Training Source Type: news

M239 successful liver transplantation in a patient with hypereosinophilic syndrome treated with mepolizumab
Hypereosinophilic syndrome (HES) is a multisystem disorder characterized by peripheral blood eosinophilia and organ impairment due to eosinophil infiltration. Mepolizumab, an anti-Il5 monoclonal antibody has been used on a compassionate basis (GSK study # 104317) to treat life threatening HES.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2020 Category: Allergy & Immunology Authors: A. Irani, C. Prazma, B. Bajaj, V. Luketic, L. Schwartz Source Type: research

Impact of Beta-lactam Allergy Label in Liver Transplant Recipients
Publication date: Available online 15 April 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Gabriel Motoa, Ismael Carrillo-Martin, Natalia Chamorro-Pareja, Daniela Haehn, Julio Mendez, Hani M. Wadei, David O. Hodge, David D. Lee, Wendelyn Bosch, Alexei Gonzalez-Estrada
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 16, 2020 Category: Allergy & Immunology Source Type: research

De Novo Allergy Development After Pediatric Liver and/or Small Bowel Transplant: A 10-Year Experience
Development of de novo allergies following solid organ transplantation has been described. We hypothesized that pediatric liver and/or small bowel transplant (LSBTX) recipients were at risk for development of de novo allergic disease.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Laura West, Kyle Soltys, Marian Michaels, Allyson Larkin Source Type: research

Six patients with rare blood disease are doing well after gene therapy clinical trial
UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.“With this gene therapy, you can use a patient’s own stem cells instead of donor cells for a transplant,” said Dr. Donald K...
Source: UCLA Newsroom: Health Sciences - January 28, 2020 Category: Universities & Medical Training Source Type: news

Clinical Management of Primary Biliary Cholangitis —Strategies and Evolving Trends
AbstractPBC is a chronic progressive autoimmune disorder involving the destruction of intrahepatic small bile ducts, cholestasis, fibrosis, and ultimately cirrhosis if left untreated. It is largely driven by the autoimmune response, but bile acids and the intestinal microbiota are implicated in disease progression as well. The only drugs licensed for PBC are UDCA and OCA. UDCA as a first-line and OCA as a second-line therapy are safe and effective, but the lack of response in a significant portion of patients and inadequate control of symptoms such as fatigue and pruritus remain as concerns. Liver transplantation is an end...
Source: Clinical Reviews in Allergy and Immunology - November 10, 2019 Category: Allergy & Immunology Source Type: research

A007 impact of penicillin allergy label in liver transplant recipients during transplant hospitalization
Self-reported penicillin (PCN) allergy is associated with broad-spectrum antibiotic use, increased antibiotic resistance, extended hospital length of stay (LoS), and increased risk of in-hospital complications including surgical site infections (SSI) and C. difficile infection (CDI). We aimed to determine the impact of self-reported PCN allergy in liver transplant recipients (LTR).
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: G. Motoa, I. Carrillo-Martin, N. Chamorro-Pareja, D. Haehn, J. Mendez, H. Wadei, D. Hodge, D. Lee, W. Bosch, A. Gonzalez-Estrada Source Type: research

High Frequency of Concomitant Food Allergy Development and Autoantibody Formation in Children Who Have Undergone Liver Transplantation
Conclusions. In contrast to respiratory allergy, food allergy and autoantibody formation occurred together in the same children who underwent liver transplantation at a frequency higher than would be expected by chance. This may reflect an underlying immune dysregulation that impairs immune tolerance to both food allergens and autoantigens.
Source: Transplantation - October 29, 2019 Category: Transplant Surgery Tags: Original Clinical Science–Liver Source Type: research

Pediatric posttransplantation food allergy experience at a large US tertiary care center
The first case of new-onset food allergy after transplantation was reported in 1997.1,2 Although posttransplantation food allergy (PTFA) is most common after liver transplantation, with a prevalence ranging from 5.6% to 38%, new-onset food allergy has also been described after bone marrow transplantation (BMT).2 –4 Tacrolimus, a medication used less frequently in BMT compared with solid organ transplantation, has been identified as a potentially modifiable risk factor for PTFA.2 Tacrolimus creates an immunologic imbalance that favors a TH2 response and increases intestinal permeability, which may increase allergen exposure via the gut.
Source: Annals of Allergy, Asthma and Immunology - August 2, 2019 Category: Allergy & Immunology Authors: Ashley Lynn Devonshire, Lauren Christine Balmert, Rajesh Kumar Tags: Letters Source Type: research

Pediatric Post-Transplantation Food Allergy Experience at a Large U.S. Tertiary Care Center
New-onset food allergy following transplantation is a described phenomenon, with the first case being reported in 1997.1,2 While post-transplantation food allergy (PTFA) is most common following liver transplantation with a prevalence ranging from 5.6 – 38%, new-onset food allergy has also been described following bone marrow transplantation (BMT).2-4 Tacrolimus, a medication used less frequently in BMT compared to solid organ transplantation, has been identified as a potentially modifiable risk factor for PTFA.
Source: Annals of Allergy, Asthma and Immunology - August 2, 2019 Category: Allergy & Immunology Authors: Ashley Lynn Devonshire, Lauren Christine Balmert, Rajesh Kumar Tags: Letters Source Type: research