Pediatric posttransplantation food allergy experience at a large US tertiary care center

The first case of new-onset food allergy after transplantation was reported in 1997.1,2 Although posttransplantation food allergy (PTFA) is most common after liver transplantation, with a prevalence ranging from 5.6% to 38%, new-onset food allergy has also been described after bone marrow transplantation (BMT).2 –4 Tacrolimus, a medication used less frequently in BMT compared with solid organ transplantation, has been identified as a potentially modifiable risk factor for PTFA.2 Tacrolimus creates an immunologic imbalance that favors a TH2 response and increases intestinal permeability, which may increase allergen exposure via the gut.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research